CAS: 53-73-6; (2-(2,4-Diamino-4-Oxobutanamido)-5-((Diaminomethylene)Amino)Pentanoyl)Valyltyrosylvalylhistidylprolylphenylalanine

上下游产品

Fm°C-Val-OH Fm°C-Pro-OH N-Fm°C L-Phe Fm°C-Tyr(tBu)-OH6-(p-chlorophenyl)-3-chloropyridazine

📜Galactosamine Pentaacetate置于三氟甲磺酸三甲基硅酯体系中,化学反应生成 血管紧张素胺
参考文献:Composition And Method For Inhibiting Angiotensinogen (Agt) Protein Expression
标题:Composition And Method For Inhibiting Angiotensinogen (Agt) Protein Expression
摘要:Provided Are A Composition And Method For Inhibiting Angiotensinogen (Agt) Protein Expression. Specifically,Provided Are A Composition And Method Capable Of Being Used For Reducing Agt Gene Expression And Treating Agt-Related Diseases And Disorders. Provided Are An Agt Dsrna Reagent Capable Of Being Used For Reducing Agt Expression In A Cell And An Object,An Agt Antisense Polynucleotide Reagent,A Composition Containing The Agt Dsrna Reagent,And A Composition Containing The Agt Antisense Polynucleotide Reagent.

专利信息

专利号:US-2023183223-A1
优先权日:2020-05-14
标题:Process for the synthesis of n-butyloxycarbonyl-3-(4-imidazol-1- ylmethylphenyl)-5-iso-butylthiophene-2-sulfonamide
发明人：CERNAKS DMITRIJS; DEGE ELIZA
权利人:VICORE PHARMA AB
摘要:There is provided a new process for the synthesis of compounds of formula I, which are useful as angiotensin (Ang II) type 2 receptor agonists: by reacting a compound of formula II, with an excess of a compound of formula III, wherein W, Z and X have meanings given in the description; followed by reaction of the intermediate so formed with a suitable source of the counter-ion, W.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:EP-2103609-A1
优先权日:2008-03-20
标 题:Catalyzed carbonylation in the synthesis of angiotensin ii antagonists
权利人:LEK PHARMACEUTICALS
摘要:One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3'-(2'-halo-biphenyl-4-ylmethyl)-1,7'-dimethyl-2'-propyl-1H,3'H-[2,5']bibenzoimidazolyl (TLMH) using either gaseous carbon monoxide in a solvent mixture containing water; or formic acid salts optionally together with acetic acid in anhydrous solvent.

专利号:US-6717007-B1
优先权日:1999-09-16
标 题:Regiospecific synthesis of phosphonous acids
发明人：DUBEY SUSHIL KUMAR; RAJGOPAL VENKAT; SINGH ANIL VIR; LAHIRI SASWATA; WANI MUKESH JAGANNATH
权利人:LUPIN LTD
摘要:An improved regiospecific synthesis of organic phosphonous acids, comprising of hydrophosphorylation of an olefin with hydrophosphorous acid in the presence of an inorganic persulfate, which acts as a source of free radicals at a pH ranging from 4.5 to 7.0, in which the orientation of addition is anti-Markonikoff. The process enables production of organic phosphonous acids at lower temperature and atmospheric pressure under milder pH conditions for better regioselectivity in hydrophosphorylation and obtain the phosphonous acid with good yield and purity following simple isolation procedure. Phosphonous acids obtained by the process are commercially valuable as effective detergents and wetting agents, lubricants and lubricant additives, plasticizers for plastics and resins, corrosion inhibitors, chemicals including insecticides and pesticides, cobalt extractants and as key intermediates for preparation of commercially important angiotensin converting enzyme (ACE) inhibitors.

专利号:US-6069248-A
优先权日:1998-08-21
标题 :Process for the synthesis of triazolopyridazine compounds
发明人：BOLDI ARMEN M; JOHNSON CHARLES R
权利人:AXYS PHARM INC
摘要:The present invention provides a process for the synthesis of triazolopyridazine based compounds represented by Formula A: ##STR1## These compounds have utility as angiotensin related antihypertensive agents.

专利号:WO-9614060-A1
优先权日:1994-11-04
标题 :Use of receptor agonists to stimulate superoxide dismutase activity
发明人：MARKLUND STEFAN L; STRAALIN PONTUS
权利人:MARKLUND STEFAN L; STRAALIN PONTUS
摘要:The present invention relates to the use of a substance for the manufacture of a composition for stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells. In particular, the invention relates to the use of a substance for the manufacture of a composition for prophylaxis or treatment of a disease or disorder connected with the presence or formation of superoxide radicals and other toxic intermediates derived from the superoxide radical. Further, the invention relates to a method for determining the effect of a substance with respect to stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells and to substances which have been selected by said method. Within the scope of the invention is a method of preventing, diminishing, controlling or inhibiting a disease or disorder connected with the presence or formation of superoxide radicals and other toxic intermediates derived from the superoxide radical in a patient who has been established to have a high risk of developing a such disease or disorder, or who has developed a such disease or disorder, the method comprising administering an effective amount of a substance which is capable of stimulating the release of EC-SOD from cells or stimulating the synthesis of EC-SOD in cells.