CAS: 52-62-0; Pentolinium Tartrate

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    专利号:US-10925977-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
    发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
    权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
    摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

    专利号:US-10814013-B2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:US-2008107598-A1
    优先权日:2006-10-05
    标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

    专利号:EP-2079486-A2
    优先权日:2006-10-05
    标题:Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:US-2013039853-A1
    优先权日:2006-10-05
    标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

    专利号:WO-2008045604-A2
    优先权日:2006-10-05
    标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

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    主要参考文献


    1: BECKER KL, SUTNICK AI. Paralytic ileus simulating acute intestinal obstruction due to pentolinium tartrate (Ansolysen). Ann Intern Med. 1961 Feb;54:313-9.
    4: Jackson KL, Marques FZ, Watson AM, Palma-Rigo K, Nguyen-Huu TP, Morris BJ, Charchar FJ, Davern PJ, Head GA. A novel interaction between sympathetic overactivity and aberrant regulation of renin by miR-181a in BPH/2J genetically hypertensive mice. Hypertension. 2013 Oct;62(4):775-81. doi: 10.1161/HYPERTENSIONAHA.113.01701. Epub 2013 Jul 29. doi: 10.1161/HYPERTENSIONAHA.113.02020. Epub 2014 Jan 20. Spanish. Am J Med Sci. 1956 Feb;231(2):140-50.
    17: Davern PJ, Chowdhury S, Jackson KL, Nguyen-Huu TP, Head GA. GABAA receptor dysfunction contributes to high blood pressure and exaggerated response to stress in Schlager genetically hypertensive mice. J Hypertens. 2014 Feb;32(2):352-62. doi: 10.1097/HJH.0000000000000015. doi: 10.1093/cvr/cvt183. Epub 2013 Jul 24. doi: 10.1097/CCM.0b013e31823da98d.

    合成参考文献


    摘要:Drugs in Japan, 6(780), 1982
    摘要:Proceedings of the Society for Experimental Biology and Medicine., 120(511), 1965 []
    参考文献:10.1046/j.1365-2125.1996.41421.x
    摘要:BOULOUX P, CORSELLO S, BESSER M, GROSSMAN A. The acute cardiovascular actions of intravenous thyrotrophin releasing hormone (TRH) in man are mediated by non‐catecholaminergic mechanisms. Brit J Clinical Pharma. 1996 Aug;42(2):225–32. doi: 10.1046/j.1365-2125.1996.41421.x.
    摘要:TARKKANEN AH, BECKER B. Aqueous humor dynamics: the effect of pentolinium (ansolysen) on normal human eyes. Am J Ophthalmol. 1958 Oct;46(4):499–501.
    摘要:JOLY F, BRIAL E. [Action of pyrroplegium bitartrate (ansolysen) on arterial hypertension; study of 27 cases]. Presse Med (1893). 1958 Sep 17;66(63):1415–8.
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