CAS: 51756-08-2; Methyl 2-Ethylacetoacetate

该化合物是乙酸的酯衍生物,主要成分为甲酸和酯功能组,该化合物是有机合成的多用途中间体,特别是在生产药品,农用化学品和特殊化学品方面.其反应性的β-甲基乙基乙酸结构能够参与凝结,通融和循环反应,从而对建立乙基循环框架具有价值.乙基替代可增强消毒和电子特性,影响合成应用中的再活动性和选择性.由于普通有机溶剂的波动性相对较小,而且溶液性较高,因此具有实际的处理优势.严格的质量控制可以确保高纯度,将敏感过程中的侧反应最小化.

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130000-32-7 17422-12-7 17094-21-2

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上下游产品

CAS号74-96-4 溴乙烷 | CAS号105-45-3 乙酰乙酸甲酯 | CAS号75-03-6 碘乙烷 | CAS号541-50-4 3-氧丁酸 | CAS号34284-28-1 乙酰乙酸甲酯钠盐 | CAS号67-56-1 甲醇 | CAS号124-41-4 甲醇钠 | CAS号141-97-9 乙酰乙酸乙酯 | CAS号13280-00-7 3-chloropentan-2-one | CAS号16244-23-8 Salvadoricine

合成工艺路线路线简述

    📜Methyl 2-(Phenylthio)Butanoate置于sodium Periodate,Zinc(II) Chloride,Lithium Diisopropyl Amide体系中,用 甲醇 作为反应溶剂,-70.0~140.0 °C,25.33 Kpa 条件下,反应 24.5H,反应生成 2-乙基乙酰乙酸甲酯
    参考文献:向α-(1-羟烷基)-和α-(1-烷氧基-烷基)-α,β-不饱和酯中添加溴
    标题:向α-(1-羟烷基)-和α-(1-烷氧基-烷基)-α,β-不饱和酯中添加溴
    摘要:电子贫烯烃,2-(1-羟烷基)-和2-(1-烷氧基烷基)丙酸酯,2B-D和(e)-2-(1-羟乙基)-2-丁烯酸甲酯的常规离子溴化3A,收益率高于80%.用两当量的强碱处理(e)-3-溴-2-[1-[(2-甲氧基乙氧基)甲氧基]丁基]丙酸16,反应可能与羟基双溴化物和溴代贝克莱德合成有关,可能通过反应生成二价阴离子19进行卤素-金属交换反应,得到丙烯酸18.
    DOI:10.1016/s0040-4020(01)89031-1

    海关参考信息

    专利信息


    专利号:US-8722887-B2
    优先权日:2006-09-22
    标 题:Sulfonylpyrazole and sulfonylpyrazoline carboxamidine derivatives as 5-HT6 antagonists
    发明人：VAN LOEVEZIJN ARNOLD; IWEMA BAKKER WOUTER I; KEIZER HISKIAS G; ZORGDRAGER JAN; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G
    权利人:VAN LOEVEZIJN ARNOLD; IWEMA BAKKER WOUTER I; KEIZER HISKIAS G; ZORGDRAGER JAN; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G; ABBVIE BAHAMAS LTD
    摘要:This invention concerns compounds of the general formula (1): n nand derivatives thereof, which are antagonists of 5-HT 6 receptors, wherein the symbols have the meanings given in the description. The invention also concerns methods for the preparation of these compounds, to novel intermediates useful for their synthesis, and to uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in treating at least on disease or condition chosen from Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, Irritable Bowel Syndrome, obesity and type-2 diabetes.

    专利号:CN-108689866-B
    优先权日:2017-04-06
    标题:Synthesis method of (R) -3-aminobutanol

    专利号:CN-112552483-A
    优先权日:2020-11-16
    标题 :A kind of self-photosensitive epoxy methacrylate resin and synthesis method thereof

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Nils Pemberton, Et Al. Synthesis Of Multi Ring-Fused 2-Pyridones Via An Acyl-Ketene Imine Cyclocondensation. Org Lett. 2006 Mar 2;8(5):935-8.

    合成参考文献


    摘要:de Gonzalo, G.; van Berkel, W. J. H.; Fraaije, M. W., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 226.
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