CAS: 475-20-7; (1S,3Ar,4S,8As)-4,8,8-Trimethyl-9-Methylenedecahydro-1,4-Methanoazulene

上下游产品

CAS号143-33-9 氰化钠 | CAS号465-24-7 longiborneol | CAS号1139-17-9 (-)-异长叶醇 | CAS号18367-70-9 [(1S,3aR,4S,8aS... | CAS号5989-08-2 (+)-α-长叶蒎烯 | CAS号116403-51-1 (-)-longicamphe... | CAS号465-26-9 8-oxolongibornane | CAS号95-13-6 茚 | CAS号86-73-7 芴 | CAS号129-00-0 芘 | CAS号1135-66-6 异长叶烯 | CAS号87064-18-4 (-)-4-CHLOROTAR... | CAS号61262-69-9 Longibornan-9-o... | CAS号59056-72-3 1-(°Ctahydro-7,... | CAS号3338-56-5 ω-Acetyl-longifolen | CAS号13928-57-9 (7S)-longifolan...

(-)-异长叶醇置于4-二甲氨基吡啶,Sodium Iodide 三乙胺体系中,用 二氯甲烷,二甲基亚砜 作为反应溶剂,化学反应 24.0H,反应生成 长叶烯
参考文献:异longifolol衍生物对人udp-葡萄糖醛酸转移酶2B7的同工型选择性抑制.
标题:异longifolol衍生物对人udp-葡萄糖醛酸转移酶2B7的同工型选择性抑制.
摘要:合成了一组48个三环倍半萜醇异长叶醇的衍生物.该组包括高手性和非对映异构的醇,胺,氯代醇,以及羧酸,膦酸及其相应的酯.差向异构化合物的绝对构型由2D NMR实验[梯度异核单量子相关性(ghsqc)和梯度核overhauser增强光谱法(gnoesy)]分配,与晶体学数据一致.三环衍生物被评估为人类udp-葡萄糖醛酸糖基转移酶(ugt)2B7的抑制剂.苯基取代的仲醇26B是该系列中最好的抑制剂,其竞争抑制常数为18 Nm.化合物26B没有被ugt2B7和其他肝脏ugt酶葡萄糖醛酸化,大概是由于其庞大的苯基取代基所造成的高位阻.确定了其对亚家族1A和2B的另外14种ugt同工型的抑制活性,并且数据表明三环仲醇26B对ugt2B7具有高度选择性(真实选择性> 1000).
DOI:10.1021/jm061204E

专利信息

专利号:US-7910623-B2
优先权日:2005-07-22
标 题 :Synthesis of scabronines and analogues thereof
发明人：DANISHEFSKY SAMUEL J; WATERS STEPHEN P
权利人:SLOAN KETTERING INST CANCER
摘要:A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. Therefore, these compounds are particularly useful in treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's diseases, etc. The invention provides for the synthesis of scabronines as well as analogs thereof. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-6843978-B2
优先权日:1999-11-24
标题:Microporous materials (TIQ-6 and METIQ-6) of high surface area active in oxidation reactions
发明人：CORMA CANOS AVELINO; FORNES SEGUI VICENTE; DIAZ MORALES URBANO; DOMINE MARCELO EDUARDO
权利人:CONSEJO SUPERIOR INVESTIGACION; UNIV VALENCIA POLITECNICA
摘要:The present invention refers to a microporous material formed by oxygen, silicon, germanium, aluminum, boron, gallium, zirconium and/or titanium in its composition, called TIQ-6, to its catalytic applications in oxidation reactions, and to a method of the TIQ-6 material's preparation based on the synthesis of a gel with a titanium and/or zirconium content, its hydrothermal treatment under controlled conditions, and the treatment of the resulting laminar material with a solution of an organic compound containing a proton accepting group. This swollen material is subjected to a specific treatment to obtain a high external area delaminated solid. A material, METIQ-6, similar to the TIQ-6 material, but also having organic groups anchored on its surface incorporated by a post-synthesis process onto the TIQ-6 material is also claimed.

专利号:US-5900227-A
优先权日:1996-06-17
标题 :Multicyclic nitrone spin trapping compositions
发明人：JANZEN EDWARD G; SANKURATRI NAGARAJU
权利人:OKLAHOMA MED RES FOUND
摘要:Multicyclic nitrone spin trapping compounds capable of forming stable free radical spin adducts are provided as well as methods for their synthesis. The multicyclic nitrone spin trapping compounds can be reacted with a free radical, such as a hydroxy or hydroperoxy radical, in solution to form a spin adduct which is stable and readily detectable by electron paramagnetic resonance (EPR) spectroscopy. The multicyclic nitrone spin traps can be used to detect free radicals in a sample such as a biological system. In one embodiment, the spin trapping compound, 1,3,3-trimethyl-6-azabicyclo-[3.2.1]oct-6-ene-N-oxide ('TRAZON') is provided, as well as methods for the synthesis of TRAZON and of modified forms of TRAZON. TRAZON can react with a wide range of different free radicals in solution to form free radical spin adducts which are readily detectable by EPR.

专利号:US-2001024798-A1
优先权日:1998-06-11
标题:Biomimetic combinatorial synthesis
发明人：SHAIR MATTHEW D; LINDSLEY CRAIG W; PELISH HENRY E; SHEEHAN SCOTT M; GOESS BRIAN C; LAYTON MARK E; CHAN LAWRENCE K; CHEN CHUO; WESTWOOD NICHOLAS J
摘要:The present invention provides biomimetic compounds and libraries thereof, as well as methods for their production. In general, the inventive method involves the selection of a desired biological synthetic pathway and mimics that synthetic pathway utilizing modern synthetic tools. The structures formed from this method are preferably generated in fewer than four steps. These scaffold structures can then be functionalized to yield biomimetic compounds and libraries of compounds. In preferred embodiments, biomimetic compounds and libraries are generated from an oxidative phenolic coupling reaction. In other particularly preferred embodiments, the compounds and libraries of compounds are generated from cascade reactions to yield bicyclo [n. 3.1 ] ring systems, medium ring systems, and fused ring systems. In addition to compounds, libraries and methods for their production, the present invention also provides pharmaceutical compositions and methods and kits for determining one or more biological activities of the library members.

专利号:US-2009186940-A1
优先权日:2005-07-22
标题 :Synthesis of Scabronines and Analogues Thereof

专利号:CN-120624590-A
优先权日:2025-05-13
标 题 :Method for regulating concentration of stress object to promote synthesis of microcystin