CAS: 433-94-3; 2-Chloro-6-(Trifluoromethyl)Aniline

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CAS号75-63-8 三氟溴甲烷 | CAS号95-51-2 2-氯苯胺 | CAS号106-47-8 对氯苯胺 | CAS号87-63-8 2-氯-6-甲基苯胺 | CAS号2314-97-8 三氟碘甲烷 | CAS号870703-71-2 4-溴-2-氯-6-(三氟甲基)苯胺

2-(Trichloromethyl)-6-Chlorophenyl Phthalimide置于氢氟酸,肼体系中,用 水 作为反应溶剂,化学反应 2.0H,反应生成 2-氨基-3-氯三氟甲苯
参考文献:N-Phenyl-N'-Pyridinylureas As Anticonvulsant Agents
标题:N-Phenyl-N'-Pyridinylureas As Anticonvulsant Agents
摘要:A Series Of N-Phenyl-N'-Pyridinylureas Was Examined For Anticonvulsant Activity. Extensive Structure/activity Investigations Revealed Optimal Activity In The N-(2,6-Disubstituted-Phenyl)-N'-(4-Pyridinyl)Urea Series,With 37 Exhibiting The Best Overall Anticonvulsant Profile. Compound 37 Was Effective Against Seizures Induced By Maximal Electroshock But Did Not Protect Mice From Clonic Seizures Produced By The Convulsant Pentylenetetrazol. The Overall Pharmacological Profile Suggests That 37 Would Be Of Therapeutic Use In The Treatment Of Generalized Tonic-Clonic And Partial Seizures. Compound 37 Was Selected For Phase 1 Clinical Trials.
DOI:10.1021/jm00164A061

专利信息

专利号:US-5420351-A
优先权日:1993-11-25
标题 :Aromatic diamine compounds
发明人：SUZUKI OSAMU; YOKOMIZO HIROHIKO; ARAI TAKESHI; NAKAJIMA NAMIKO
权利人:NISSHIN SPINNING
摘要:An aromatic diamine compound represented by formula (1): ##STR1## wherein R 1 and R 2 , which may be the same or different, are each a hydrogen atom or a lower alkyl group; and an aromatic diamine compound useful as an intermediate for the synthesis of the above compound (1), represented by formula (2): ##STR2## The compound (1) alleviates the problems of the prior art, and is unlikely to cause crystallization by heat and has a melting point and a glass transition temperature both higher than those of conventional compounds.