CAS: 42491-77-0; (R)-4-(((Benzyloxy)Carbonyl)Amino)-2-Hydroxybutanoic Acid

相似化合物

40371-51-5 40371-50-4 54755-69-0

上下游产品

CAS号54755-69-0 2-羟基-4-苄基丁氧基羰基胺 丁 酸 | CAS号81323-56-0 methyl 2-oxo-4-...

📜Methyl N-Benzyloxycarbonyl-4-Amino-2-Oxobutanoate 在 Sodium Hydroxide,1,4-Dihydronicotinamide Adenine Dinucleotide,Tris Buffer Ph 6.5-7.0,Sodium Formate,1,4-二巯基-2,3-丁二醇体系中,反应 168.0H,获得 (R)-4-Benzyloxycarbonylamino-2-Hydroxybutanoic Acid
参考文献:Enantioselective Syntheses Of (S)-And (R)-3-Hydroxypyrrolidin-2-Ones Via Lactate Dehydrogenase Catalysed Reductions Of 4-Benzyloxycarbonylamino-2-Oxobutanoic Acid
标题:Enantioselective Syntheses Of (S)-And (R)-3-Hydroxypyrrolidin-2-Ones Via Lactate Dehydrogenase Catalysed Reductions Of 4-Benzyloxycarbonylamino-2-Oxobutanoic Acid
摘要:首次描述了bs-和se-乳酸脱氢酶催化的一个α-酮酸还原反应,其中侧链包含氮功能团:(S)-和(R)-苄氧羰基氨基-2-羟基丁酸以良好的产率和优异的对映选择性制备成功,并分别转化为(S)-和(R)-3-羟基吡咯烷-2-酮.
Doi:10.1039/C39950000231

专利信息

专利号:US-5763587-A
优先权日:1987-11-27
标题:Process for the synthesis of amikacin
发明人：MANGIA ALBERTO
权利人:GIST BROCADES ITALY SPA
摘要:In the synthesis of amikacin, having the formula: (I) by acylation of a diprotected derivative of kanamycin A with a reactive derivative of L-(-)-4-amino-2-hydroxybutyric acid, the selection of the reaction solvent and of the pH conditions permit the industrial economically and the synthesis yield to be improved.

专利号:US-4902790-A
优先权日:1985-10-10
标 题 :Novel process for the synthesis of amikacin
发明人：MANGIA ALBERTO; GIOBBIO VICENZO; ORNATO GIORGIO
权利人:PIERREL SPA
摘要:A novel process for the synthesis of amikacin starting from kanamycin A protected at the positions 3 and 6' is described comprising the reaction of kanamycin A with a salt of a bivalent metal cation selected from zinc, nickel, iron, cobalt, manganese, copper and cadmium in the presence of water as the solvent or co-solvent followed by the in situ reaction of the resulting complex with a reactive derivative of L-amino-2-hydroxy-butyric acid, removal of the metal cation of the protecting groups and purification of the thus obtained raw product. The acylation under these conditions is extremely selective.

专利号:US-6033882-A
优先权日:1994-07-07
标题:Chiral synthesis of 2-hydroxy carboxylic acids with a dehydrogenase
发明人：HOLBROOK JOSEPH JOHN; WILLIS CHRISTINE LOUISE; JOHNSEN KEYJI; HATELEY MARTIN JOHN
权利人:GENZYME CORP
摘要:PCT No. PCT/EP95/02692 Sec. 371 Date May 29, 1997 Sec. 102(e) Date May 29, 1997 PCT Filed Jul. 7, 1995 PCT Pub. No. WO96/01892 PCT Pub. Date Jan. 25, 1996Inter alia, an enzyme, a 2-hydroxy carboxylic acid dehydrogenase, characterised in that it is obtainable from Lactobacillus delbrueckii ssp. Bulgaricus and in that it catalyses the production of (R)-hydroxy derivatives of 2-keto acids, which are unsubstituted in the 3-position, but which may be substituted in the 4-position or beyond is disclosed.

专利号:WO-9601892-A1
优先权日:1994-07-07
标 题 :Chiral synthesis of 2-hydroxy carboxylic acids with a dehydrogenase

专利号:EP-0218292-B1
优先权日:1985-10-10
标题:Novel process for the synthesis of amikacin

专利号:EP-0767832-A1
优先权日:1994-07-07
标题:Chiral synthesis of 2-hydroxy carboxylic acids with a dehydrogenase