CAS: 39149-80-9; Tert-Butyl 2-Bromopropanoate

相似化合物

32644-15-8 10009-70-8 23877-12-5

上下游产品

CAS号598-72-1 2-溴丙酸 | CAS号115-11-7 2-甲基丙烯 | CAS号563-76-8 2-溴丙酰溴 | CAS号75-65-0 叔丁醇 | CAS号7148-74-5 2-溴丙酰氯 | CAS号1694-31-1 乙酰乙酸叔丁酯 | CAS号74-88-4 碘甲烷 | CAS号26735-86-4 tert-butyl 2-me... | CAS号124929-03-9 tert-butyl 2-ph... | CAS号89278-16-0 tert-butyl 2-ph... | CAS号59854-10-3 tert-butyl 2-hy...

2-溴丙酸,异丁烯置于硫酸体系中,用 二氯甲烷 用作溶剂,化学反应 18.0H,以82%的收率获得2-溴丙酸叔丁酯
参考文献:血管紧张素转换酶抑制剂:具有降压活性的新型口服活性1,4-噻嗪-2,5-二酮,1,4-噻嗪-2,5-二酮和1,4-苯并噻嗪-2,5-二酮.
标题:血管紧张素转换酶抑制剂:具有降压活性的新型口服活性1,4-噻嗪-2,5-二酮,1,4-噻嗪-2,5-二酮和1,4-苯并噻嗪-2,5-二酮.
摘要:一系列1,4-噻嗪-2,5-二酮,1,4-噻嗪-2,5-二酮和1,4-苯并硫氮杂-2,5-二酮的制备及其抑菌活性检查了体内和体外的血管紧张素转换酶(ace).这些化合物被假定为前药,因为它们在与大鼠血浆一起温育或经0.1 N Hcl水溶液或磷酸盐缓冲液(ph 7.4)处理时会发生快速的开环反应,以产生相应的无生物活性的sh化合物.噻嗪类23-25和30在向大鼠口服给药时是ace的有效抑制剂,其效力与卡托普利(1)相当.大鼠中最活跃的噻嗪类化合物分别为42和45.在所研究的苯并硫氮平中,22A在有意识的正常血压大鼠中抑制ace的活性最高,Id50 = 0.15 Mg / Kg,Po.
Doi:10.1021/jm00155A032

专利信息

专利号:US-10844081-B2
优先权日:2015-08-07
标题 :Protected organoboronic acids with tunable reactivity, and methods of use thereof
发明人：BURKE MARTIN D; SCHMIDT MICHAEL; MOREHOUSE GREG; PIPAL ROBERT W
权利人:UNIV ILLINOIS
摘要:Disclosed are a range of protected organoboronic acid reagents useful in the modular assembly of complex organic compounds. The reactivities of the protected organoboronic acid reagents may be varied predictably by changes to the number and identities of their substituents. Also disclosed are methods of using the protected organoboronic acid reagents in the synthesis of organic compounds.

专利号:US-2003232820-A1
优先权日:2001-08-29
标题:Method for synthesizing oxazinones
发明人：WOLFE SAUL; WILSON MARIE-CLAIRE; CHENG MING-HUEI
摘要:New methods and intermediates are discussed for the stereospecific synthesis of oxazinone compounds.

专利号:US-11702430-B2
优先权日:2018-04-03
标 题:Aza-benzothiophene compounds as STING agonists
发明人：ALTMAN MICHAEL D; CASH BRANDON D; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW M; JEWELL JAMES P; LARSEN MATTHEW A; LU MIN; OTTE RYAN D; TAOKA BRANDON M; TROTTER BENJAMIN WESLEY; TRUONG QUANG T
权利人:MERCK SHARP & DOHME LLC; ALTMAN MICHAEL D; CASH BRANDON D; CUMMING JARED N; DEMONG DUANE E; HAIDLE ANDREW M; JEWELL JAMES P; LARSEN MATTHEW A; LU MIN; OTTE RYAN D; TAOKA BRANDON M; TROTTER BENJAMIN WESLEY; TRUONG QUANG T
摘要:Compounds of general formula (I), and their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , R 5 , R 6 , R 8 , R 9 , A, X 1 , X 2 , and X 3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

专利号:US-2012259073-A1
优先权日:2004-04-13
标 题 :Methods for the synthesis of modular poly(phenyleneethynylenes) and fine tuning the electronic properties thereof for the functionalization of nanomaterials

专利号:US-2006054866-A1
优先权日:2004-04-13
标 题 :Methods for the synthesis of modular poly(phenyleneethynlenes) and fine tuning the electronic properties thereof for the functionalization of nanomaterials

专利号:US-4410520-A
优先权日:1981-11-09
标题 :3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
发明人：WATTHEY JEFFREY W H
权利人:CIBA GEIGY CORP
摘要:Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzaz epin-2-ones and functional derivatives are angiotension converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.