CAS: 34300-94-2; 3-Mercapto-3-Methylbutan-1-Ol

相似化合物

51755-83-0 94087-83-9 50746-09-3

上下游产品

3-mercapto-3-methylbutanoic acid 3-methyl-3-thiobenzylbutan-1-ol 3-mercapto-3-methylbutanal 3,3-dimethyl acrylaldehyde 2,2-Dimethylthietane (+/-)-felinine (E)-2-(2-phenyl-ethenyl)-4,4-dimethyl-1,3-oxathiane trans-2-(p-methoxystyryl)-4,4-dimethyl-1,3-oxathiane

3,3-二甲基丙烯酸置于哌啶,Sodium Amide体系中,用 氨 用作溶剂,化学反应生成3-巯基-3-甲基-1-丁醇
参考文献:生物导向的有机硫化学.8.青霉素类似物和衍生物的构效关系.
标题:生物导向的有机硫化学.8.青霉素类似物和衍生物的构效关系.
摘要:
Doi:10.1021/jm00291A024

专利信息

专利号:US-6469065-B1
优先权日:1996-02-02
标 题:Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
发明人：GARVEY DAVID S; SCHROEDER JOSEPH D; DE TEJADA INIGO SAENEZ; GASTON RICKY D; SHELEKHIN TATIANA E; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.

专利号:US-2005187222-A1
优先权日:1996-02-02
标题:Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds
发明人：GARVEY DAVID S; DE TEJADA INIGO S; GASTON RICKY D; KHANAPURE SUBHASH P; SHELEKHIN TATIANA E; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.

专利号:WO-2018146166-A1
优先权日:2017-02-07
标 题:Heterobifunctional linkers for modifying thiols
发明人：EKSTEEN JACOBUS JOHANNES; SENGEE MYAGMARSUREN; SYDNES LEIV KRISTEN
权利人:NORUT NORTHERN RES INSTITUTE AS
摘要:The invention relates to certain compounds of formula (I) (I) wherein Y is an electron-withdrawing group; Q is (formula) Z is a leaving group; J is NR5, with R5 being hydrogen or a substituted or unsubstituted alkyl, alkenyl, alkynyl or aryl group. R1 to R4 optional substituents and m is an integer between 1 and 12; n is an integer between 0 and 4; o is between 0 and 4. These compounds are useful as linkers for realisably joining a targeting moiety such as an antibody to a 'cargo' compound such as a drug, particularly an anti-cancer drug. The invention also relates to conjugates of a targeting moiety and a drug utilising the linker, to methods of synthesis of the linker and to processes for the production of the conjugate. The use of the conjugate in the treatment of disease such as cancer is also disclosed.

专利号:US-11548909-B2
优先权日:2015-11-06
标 题 :Methods of using nucleotide analogues
发明人：Marma Mong Sano; OLEJNIK JERZY; KORBOUKH ILIA
权利人:ISOPLEXIS CORP
摘要:The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.

专利号:US-11821032-B2
优先权日:2018-01-24
标 题 :DNA sequencing reaction additive
发明人：ANDRUZZI LUISA; ADEDIRAN JIMMY; PELLETIER TIMOTHY; RICKER AUSTIN; DeLucia Angela; MCNALLY BEN; HEVRONI DONA; Marma Mong Sano; SHERIDAN JOHN ANDREW
权利人:ISOPLEXIS CORP
摘要:The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3′-O position capped by a disulfide-based 3′-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.

专利号:US-11421264-B2
优先权日:2015-11-06
标 题:Thiol-containing cleave reagents and oxidative wash
发明人：Marma Mong Sano; ANDRUZZI LUISA; MCNALLY BEN; DeLucia Angela; HEVRONI DONA; CARPENTER ELIZABETH; BESEV MAGNUS
权利人:ISOPLEXIS CORP
摘要:The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3′-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.