专利号:US-2025214918-A1 优先权日:2022-05-20 标 题:Functionalization of terpenes by selective deprotonation for the synthesis of (+)-artemisinin and related compounds 发明人:FRANTZ DOUG E; BLUMBERG SHAWN; ORTIZ ELIEZER; CLANTON NICHOLAS; WILSON NICK 权利人:UNIV TEXAS 摘要:The present invention provides methods for the preparation of (+)-Artemisinin and intermediates thereof, including via the regioselective deprotonation of amorphadiene (AD). In other aspects, there are provided methods for the functionalization terpenes by selective deprotonation, including the utilization of 4,11-amorphadiene as an industrially viable feedstock for the synthesis of artemisinin. In some embodiments, these methods are broadly applicable to the derivatization of a variety of cyclic and linear terpenes.
专利号:EP-2465936-A1 优先权日:2010-12-20 标题 :Enzymatic synthesis of statins and intermediates thereof 权利人:LEK PHARMACEUTICALS 摘要:The present invention discloses a process for preparing an active pharmaceutical ingredient (API) or intermediates thereof, notably particular step in the synthesis of an intermdiate useful for example in the preparation of statins, by using an enzyme capable of catalyzing oxidation or dehydrogenation. The invention further provides an expression system effectively translating said enzyme. In addition, the invention relates to a specific use of such enzyme for preparing API or intermediate thereof, and in particular for preparing statin or interemediate thereof.
专利号:US-5043328-A 优先权日:1986-05-09 标 题 :Formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems 发明人:WEITHMANN KLAUS U 权利人:HOECHST AG 摘要:The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.
专利号:US-11311505-B2 优先权日:2017-02-24 标 题:Synergistic compositions to stimulate the synthesis of human lung and sinus surfactants to decrease coughing, increase FEV-1/FVC ratios, decrease lung fibrosis, by increasing apoptosis of myofibroblasts 发明人:MARTIN ALAIN 权利人:MARTIN ALAIN; CELLULAR SCIENCES INC 摘要:Methods for the treatment of patients with both Chronic Obstructive Pulmonary Disease (COPD) and pulmonary fibrosis, and of patients with idiopathic pulmonary fibrosis without COPD, by stimulating the synthesis of human and animal patient lung and sinus surfactants to increase lung functions, inhibiting fibrosis and reducing coughing and nasal erythema, include the following steps: A) analyzing and diagnosing a patient with a lung ailment selected from the group consisting of i) both COPD and pulmonary fibrosis; and ii) idiopathic pulmonary fibrosis without COPD; and, B) treating the patient to raise the patient's lung functions including FEV1/FVC ratio by contacting mammalian cells with a [therapeutically effective amount of a treatment] composition that includes: a) a pyruvate salt; b) a phosphate; c) a salt of calcium; and d) a salt of magnesium, in an aqueous carrier, containing no more than 2.2 grams of said pyruvate salt per liter.
专利号:US-2024132430-A1 优先权日:2021-08-05 标 题 :Chemicals and use of hypohalites in mechanism-based selective dual radical organic synthesis 发明人:PALOMINO EDUARDO 权利人:WALKER CANCER RES INSTITUTE INC 摘要:The synthesis of pattern-specific compounds using hypohalites, such as hypochlorous acid, sodium hypochlorite, and potassium hypoiodite, as dual-radical generators is provided. The synthesis can be implemented by a cyclization reaction, a dehydrogenation reaction, a hydroxylation reaction, a decarboxylation reaction, or any combination of the above four. The reactions are typically carried out in water, in a nonpolar solvent such as ethyl acetate, or a mixture of both. Hypochlorous acid is made by adding a weak acid such as acetic acid to sodium hypochlorite.
专利号:US-5280093-A 优先权日:1989-06-29 标题 :Chiral polymers for the synthesis of pure enantiomers of amino acids 发明人:JACQUIER ROBERT; CALMES MONIQUE; DAUNIS JACQUES 权利人:RHONE POULENC CHIMIE 摘要:The present invention relates to chiral polymers and to their uses for operations of asymmetric synthesis, deracemization and optical inversion. n These polymers are characterized in that they comprise: n a chiral unit n a functionalizing unit n an optional crosslinking unit n Application to chiral organic synthesis.