CAS: 306-83-2; 1,1-Dichloro-2,2,2-Trifluoroethane

该化合物是一种无色,非易燃的液体,有甜味,属于氟氯烃(HCFCs)类别,主要用作空调和制冷系统的制冷剂.该化合物的化学配方是C2HCl2F3,表明存在两个氯原子和三氟原子,它们附在两碳乙烷主干柱上.它有一个相对较低的沸点,在热传染应用方面十分有效.与其它卤化碳相比,HCFC-123具有适度的臭氧消耗潜力,这导致根据<蒙特利尔议定书>等国际协定逐步减少.此外,它的全球升温潜能低于许多其他制冷剂,但仍引起环境问题.安全数据表明,它可能会引起呼吸刺激,应当谨慎地加以处理,使用适当的个人保护设备.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

REACH注册ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号127-18-4 四氯乙烯 | CAS号354-58-5 1,1,1-三氯-2,2,2-三氟乙烷 | CAS号2837-89-0 1,1,1,2-四氟-2-氯乙烷 | CAS号75-88-7 2-氯-1,1,1-三氟乙烷 | CAS号79-35-6 1,1-二氯-2,2-二氟乙烯 | CAS号116-14-3 四氟乙烯 | CAS号354-23-4 1,2-二氯三氟乙烷 | CAS号354-21-2 1,2,2-三氯-1,1-二氟乙烷 | CAS号10026-12-7 五氯化铌 | CAS号23153-23-3 1,1,1,3,3-Penta... | CAS号7647-01-0 盐酸 | CAS号384-54-3 2,3-二氯-1,1,1,4,... | CAS号378-84-7 2,2,3-三氯-1,1,1,... | CAS号375-34-8 六氟-2,2,3,3-四氯丁烷 | CAS号75-88-7 2-氯-1,1,1-三氟乙烷 | CAS号359-10-4 2-氯-1,1-二氟乙烯 | CAS号67230-92-6 2-chloro-3,3-di... | CAS号138950-21-7 2-chloro-1,1,1-... | CAS号354-33-6 五氟乙烷

合成工艺路线路线简述

    📜四氯乙烯置于氢氟酸,五氟化锑体系中,120.0 °C,1.5 Mpa 条件下,反应 7.0H,以94.2%的收率获得产物二氯三氟乙烷
    参考文献:一种联产制备1,1,2-三氟三氯乙烷和1,1,1-三氟二氯乙烷的方法
    标题:一种联产制备1,1,2-三氟三氯乙烷和1,1,1-三氟二氯乙烷的方法
    摘要:本发明公开了一种联产制备1,1,2‑三氟三氯乙烷和1,1,1‑三氟二氯乙烷的方法,包括如下制备过程:在反应高压釜中,先投入反应原料氢氟酸,六氯乙烷及四氯乙烯进行反应,原料氢氟酸,六氯乙烷及四氯乙烯的摩尔比为(10~40)∶(0.8~2.5)∶(1.2~3.6),然后加入催化剂进行催化作用,催化剂为金属氟化物或金属氯化物,金属氟化物包括alf3,Sbf3,Sbf5,Znf2,金属氯化物包括sbcl5,反应温度控制在30~250°C,反应时间控制在2~12H,反应压力控制在0.3~3.0Mpa,待反应结束后通过水洗,碱洗,精馏提纯,最终得到产物1,1,2‑三氟三氯乙烷和1,1,1‑三氟二氯乙烷.本合成方法原料来源丰富,比较廉价,反应收率高,反应进料容易,反应生成的产物容易分离提出,可以实现工业化连续生产.

    海关参考信息

    专利信息


    专利号:US-2008032964-A1
    优先权日:2006-04-10
    标题:Process for the synthesis of azetidinone
    发明人：KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
    权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
    摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

    专利号:WO-2024105700-A1
    优先权日:2022-11-18
    标 题:A method for the synthesis of anthranilic amide compounds and intermediates thereof
    发明人：MALVIYA NITIN; MAL SANJIB; KLAUSENER ALEXANDER G M
    权利人:PI INDUSTRIES LTD
    摘要:The present invention discloses a method for the synthesis of a compound of formula (V) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The method further comprises the synthesis of an anthranilic diamide compound of formula (Z).

    专利号:US-2023339844-A1
    优先权日:2020-09-17
    标题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
    发明人：MAHAPATRA TRIDIB; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M; MAL SANJIB; SHARMA RAJU
    权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
    摘要:The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, n n n n n n n n n n wherein, R, R 1 , R 2 , R 3 and R 10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

    专利号:US-2023339906-A1
    优先权日:2020-09-26
    标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof
    发明人：SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M
    权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD
    摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).

    专利号:US-8128902-B2
    优先权日:2011-04-12
    标题:Method for the synthesis of anhydrous hydrogen halide and anhydrous carbon dioxide
    发明人：TARANCON III GREGORIO
    权利人:TARANCON III GREGORIO; MIDWEST REFRIGERANTS LLC
    摘要:A method for the synthesis of anhydrous hydrogen halide fluids from organic halide fluids, such as perfluorocarbon fluids and refrigerant fluids, and anhydrous carbon dioxide for the environmentally safe disposition thereof.

    专利号:US-8043574-B1
    优先权日:2011-04-12
    标 题:Apparatus for the synthesis of anhydrous hydrogen halide and anhydrous carbon dioxide
    发明人：TARANCON III GREGORIO
    权利人:MIDWEST REFRIGERANTS LLC
    摘要:An apparatus for the synthesis of anhydrous hydrogen halide fluids from organic halide fluids, such as perfluorocarbon fluids and refrigerant fluids, and anhydrous carbon dioxide for the environmentally safe disposition thereof.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:National Technical Information Service., OTS0530608
    摘要:Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc p. 813 (1990)
    摘要:US EPA; Inventory Update Reporting (IUR). Nonconfidential 2006 IUR Records by Chemical, including Manufacturing, Processing and Use Information. Washington, DC: U.S. Environmental Protection Agency. Available from, as of December 6, 2012:
    摘要:EPA/Office of Pollution Prevention and Toxics; High Production Volume (HPV) Challenge Program. Ethane, 2,2-dichloro-1,1,1-trifluoro- (306-83-2). Available from, as of February 28, 2013:
    摘要:Currance, P.L. Clements, B., Bronstein, A.C. (Eds).; Emergency Care For Hazardous Materials Exposure. 3Rd edition, Elsevier Mosby, St. Louis, MO 2005, p. 222
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