CAS: 24599-58-4; 2,5-Dimethoxytoluene

上下游产品

methanol 2-methylbenzene-1,4-diol sodium methylate 2-Methyl-1,4-benzoquinone 4-(2,5-dimethoxy-4-methyl-phenyl)-4-oxo-butyric acid 2-(Chloromethyl)-5-methyl-1,4-dimethoxybenzene bis(2,5-dimethoxy-4-methylphenyl)methane 2,5-dimethoxybenzyl chloride

📜甲基苯醌置于氢气,Potassium Hydroxide体系中,用 四氢呋喃,水 用作溶剂,30.0 °C,101.33 Kpa 条件下,反应生成2,5-二甲氧基甲苯
参考文献:通过使用非均相au-Pt纳米粒子作为催化剂的连续和连续流加氢衍生化作用,由醌直接合成对苯二酚
标题:通过使用非均相au-Pt纳米粒子作为催化剂的连续和连续流加氢衍生化作用,由醌直接合成对苯二酚
摘要:固定在二甲基聚硅烷上的pt-Au双金属纳米颗粒催化剂(pt-Au /(dmpsi-Al 2 O 3))已开发用于将醌选择性加氢为对苯二酚.在连续流动条件下证实了催化剂的高反应活性,选择性和坚固性.在连续和连续流动条件下成功进行了醌的各种直接衍生化反应,例如甲基化,乙酰化,三氟甲磺酰化,甲基丙烯酸化和苯甲酰化,以非常好的收率提供了所需的产品,甚至具有优异的收率.尤其是,对空气敏感的氢醌,如蒽氢醌和萘氢醌,可以在封闭的连续和连续流动条件下成功生成并衍生化而不会分解.
Doi:10.1002/anie.201904159

专利信息

专利号:US-6355826-B1
优先权日:1997-09-17
标题:Synthesis of stable nitrile oxide compounds
发明人：PARKER DANE KENTON
权利人:GOODYEAR TIRE & RUBBER
摘要:This invention discloses a process for the synthesis of stable aryl nitrile oxides which comprises the sequential steps of (1) halomethylating a halomethyl group onto a substituted aromatic compounds wherein said halomethyl group is halomethylated onto a position that is ortho to at least one of the substituent groups on the substituted aromatic compound; (2) converting the ortho halomethylated-substituted aromatic compound into an ortho-substituted aromatic aldehyde by reacting the ortho halomethylated-substituted aromatic compound with a salt selected from the group consisting of sodium 2-nitropropane and potassium 2-nitropropane in a lower alcohol solvent; (3) converting the ortho-substituted aromatic aldehyde into an ortho-substituted aromatic; and (4) converting the ortho-substituted aromatic oxime into the ortho-substituted aryl nitrile oxide by reacting the ortho-substituted aromatic oxime with an aqueous sodium hypochlorite solution.

专利号:US-8106031-B2
优先权日:2006-05-02
标题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:US-7884128-B2
优先权日:2005-10-13
标题:Process for total synthesis of pladienolide B and pladienolide D
发明人：KANADA REGINA MIKIE; ITO DAISUKE; SAKAI TAKASHI; ASAI NAOKI; KOTAKE YOSHIHIKO; NIIJIMA JUN
权利人:EISAI R&D MAN CO LTD
摘要:Process for producing compound of Formula: n nwherein P 2 , P 3 and R 2 are the same as defined below, characterized by comprising reacting a compound represented by Formula (7):n n nwherein P 3 means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8):n n nwherein P 2 means a protecting group for hydroxy group; and R 2 means a phenyl group which may be substituted, in the presence of a base.

专利号:US-7803955-B2
优先权日:2005-06-16
标 题:Method for preparing 2,5,7,8-tetramethyl-2-(2′-carboxyethyl)-6-acetoxychroman-precursor- α-CEHC precursor
发明人：SPIVAK ANNA YULIEVNA; ODINOKOV VIKTOR NIKOLAEVICH; KNYSHENKO OXANA VALERIEVNA
权利人:INST NEFTEKHIMII I KATALIZA RA
摘要:The contemplated invention relates to the field of synthesis of biologically active substances, namely to the synthesis of an acetate derivative of the main water-soluble α-tocopherol metabolite known under the name of α-CEHC, which is prepared by the acid-catalyzed reaction of condensation of trimethyl hydroquinone with linalool in boiling octane, using n-toluenesulfonic acid or (+)-camphor-10-sulfonic acid as the catalyst. The reaction is carried out for 3 hours at the trimethyl hydroquinone:linalool:catalyst mole ratio of 1:1:0.1. The forming product is acetylated with acetic anhydride in pyridine at room temperature for 0.5 hour, and then ozonized in acetone in the presence of Ba(OH) 2 , oxidized with Jones' reagent in acetone, and isolated on silica gel column chromatography. n Said compound is an acetate derivative of the main α-tocopherol metabolite—α-CEHC, for which high efficiency has been noted in treating disorders of the central nervous system.

专利号:US-7612064-B2
优先权日:2003-05-26
标题:Sulfopyrroles
发明人：EBERLE MARTIN; ERMERT PHILIPP; OBRECHT DANIEL; LACH FRANK; LUTHER ANATOL; BACHMANN FELIX; STREBEL ALLESSANDRO
权利人:TAKEDA PHARMACEUTICAL
摘要:The invention relates to compounds of formula (I) wherein R 1 represents aryl, aralkyl or heteroaryl, R 2 is aryl or heteroaryl and R 3 is aryl, heteroaryl or optionally substituted aminomethyl, to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using compounds of formula (I) or of pharmaceutical compositions containing same.

专利号:CN-114940668-A
优先权日:2022-03-23
标题 :Preparation of a catalyst and its application in the synthesis of vitamin E acetate