CAS: 2230198-02-2; (S)-2-((4-(6-((4-Cyano-2-Fluorobenzyl)Oxy)Pyridin-2-yl)Piperidin-1-yl)Methyl)-1-(Oxetan-2-Ylmethyl)-1H-Benzo[d]Imidazole-6-Carboxylic Acid

📜2,6-二氯吡啶置于tris-(Dibenzylideneacetone)Dipalladium(0),正丁基锂,1,5,7-三氮杂双环[4.4.0]癸-5-烯,水,对甲苯磺酸,N,N-二异丙基乙胺,Sodium Hydroxide,2-(二叔丁基膦)联苯体系中,用 四氢呋喃,1,4-二氧六环,甲醇,正庚烷,水,乙酸乙酯,1,2-二氯乙烷,乙腈 用作溶剂,化学反应 10.25H,反应生成2-[[4-[6-[(4-氰基-2-氟苯基)甲氧基]-2-吡啶基]-1-哌啶基]甲基]-1-[(2S)-2-氧杂环丁烷基甲基]-1H-苯并咪唑-6-羧酸
参考文献:Glp-1 Agonists And Uses Thereof
标题:Glp-1 Agonists And Uses Thereof
摘要:本文提供苯并咪唑的6-羧酸和4-氮杂,5-氮杂,7-氮杂和4,7-二氮杂苯并咪唑作为glp-1R激动剂,制备该化合物的方法,以及包括将该化合物给予需要的哺乳动物的方法.

专利信息

专利号:WO-2025128985-A1
优先权日:2023-12-14
标题 :Sulfoxide and sulfone derivatives of thiocarbazates as synthons for azapeptides synthesis and process of using same
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Provided for herein are sulfoxide and sulfone derivatives of thiocarbazates that have the formula (I): wherein A, R, R 1 , R 2 , and n are defined herein. The compounds may be used as synthons in the synthesis of azaeptides and other aza- amino acid conjugates.

专利号:WO-2025080818-A1
优先权日:2023-10-10
标 题:Combinations of fasn inhibitors and glp-1 agonists for liver diseases
发明人：O'FARRELL ANNE-MARIE; TSAI WEN-WEI
权利人:SAGIMET BIOSCIENCES INC
摘要:Combinations of fatty acid synthesis (FASN) inhibitors and glucagon-like peptide-1 (GLP-1) agonists for treating NAFLD/MAFLD, NASH/MASH, liver fibrosis and/or liver cirrhosis.

专利号:WO-2021018023-A1
优先权日:2019-08-01
标题:Small molecule glp-1 receptor modulator
发明人：XIE FANG; YU GUANGXIA; ZHANG SHUJUAN
权利人:THE TITAN LEADING MED TECH INC
摘要:The present invention provides a new compound for modulating a Glucagon-like peptide-1 (GLP-1) receptor, and a synthesis method therefor and a pharmaceutical use thereof. This kind of compound has an obvious agonistic effect on the GLP-1 receptor, but does not have an obvious binding effect on hERG, and therefore, it is indicated that the compound has a low risk of cardiotoxicity. The compound of the present invention can be used alone as a treatment medication for type II diabetes, or be used in combination with a polypeptide GLP-1 receptor agonist such as liraglutide, or be used in combination with the treatment medication for type II diabetes of other mechanisms.

专利号:CN-116102543-A
优先权日:2022-10-21
标题 :A kind of GLP-1R agonist, synthesis method and use thereof