CAS: 2105904-82-1; (((((2R,3S,4R,5R)-5-(6-Chloro-4-(((S)-1-(2-Fluorophenyl)Ethyl)Amino)-1H-Pyrazolo[3,4-B]Pyridin-1-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methoxy)(Hydroxy)Phosphoryl)Methyl)Phosphonic Acid
- 英文名称(((((2R,3S,4R,5R)-5-(6-Chloro-4-(((S)-1-(2-Fluorophenyl)Ethyl)Amino)-1H-Pyrazolo[3,4-B]Pyridin-1-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methoxy)(Hydroxy)Phosphoryl)Methyl)Phosphonic Acid
- 中文名称(((((2R,3S,4R,5R)-5-(6-氯-4-(((S)-1-(2-氟苯基)乙基)氨基)-1H-吡唑并[3,4-B]吡啶-1-基)-3,4-DI羟基四氢呋喃-2-基)甲氧基)(羟基)磷酰基)甲基)基羧酸
- IUPAC名称(((((2R,3S,4R,5R)-5-(6-chloro-4-(((S)-1-(2-fluorophenyl)ethyl)amino)-1H-pyrazolo[3,4-b]pyridin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methyl)phosphonic acid
- 其它别名Unii-J6K8Wsv73A; [[(2~{r},3~{s},4~{r},5~{r})-5-[6-Chloranyl-4-[[(1~{s})-1-(2-Fluorophenyl)Ethyl]Amino]Pyrazolo[3,4-B]Pyridin-1-Yl]-3,4-Bis(Oxidanyl)Oxolan-2-Yl]Methoxy-Oxidanyl-Phosphoryl]Methylphosphonic Acid; [[(2R,3S,4R,5R)-5-[6-Chloro-4-[[(1S)-1-(2-
- CAS编号2105904-82-1
- MFCD编号:MFCD32062822
- FDA UNII编号:J6K8WSV73A
- 分子式:C20H24ClFN4O9P2分子量:580.83
- 产品CID: 1089596
- 产品分类Chemistry → Heterocyclic Building Blocks → Aromatic Heterocycles
物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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专利信息
专利号:US-2022259202-A1
优先权日:2019-06-17
标题:1-(4-(aminomethyl)benzyl)-2-butyl-2h-pyrazolo[3,4-c]quinolin-4-amine derivatives and related compounds as toll-like receptor (tlr) 7/8 agonists, as well as antibody drug conjugates thereof for use in cancer therapy and diagnosis
发明人：MEIMETIS LABROS
权利人:SUTRO BIOPHARMA INC
摘要:1-(4-(aminomethyl)benzyl)-2-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine derivatives thereof and related compounds of formula (I) as toll-like receptor (TLR) 7/8 agonists for cancer therapy. Linker payload compounds thereof, and antibody conjugates thereof for cancer diagnosis. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 145 to 156; examples 1 to 3; biological examples 1 to 6; tables 1 and 2).
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Bowman CE, da Silva RG, Pham A, Young SW. An Exceptionally Potent Inhibitor of Human CD73. Biochemistry. 2019 Aug 6;58(31):3331-3334. doi: 10.1021/acs.biochem.9b00448. Epub 2019 Jul 23.
合成参考文献
参考文献:10.1021/acs.jmedchem.0c01044
摘要:Jeffrey JL, Lawson KV, Powers JP. Targeting Metabolism of Extracellular Nucleotides via Inhibition of Ectonucleotidases CD73 and CD39. J Med Chem. 2020 Nov 25;63(22):13444–65. doi: 10.1021/acs.jmedchem.0c01044.
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