CAS: 1778-02-5; Pregnenolone Acetate

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809-51-8 35602-69-8 24365-37-5

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CAS号979-02-2 16-脱氢孕烯醇酮乙酸酯 | CAS号145-13-1 孕烯醇酮 | CAS号108-24-7 乙酸酐 | CAS号17916-30-2 Pregn-5-en-20-o... | CAS号76984-91-3 3β-acetoxypregn... | CAS号111968-94-6 20-(phenylthioi... | CAS号75-36-5 乙酰氯 | CAS号6661-94-5 5β,6β-Epoxy-20-... | CAS号6661-94-5 5β,6β-Epoxy-20-... | CAS号14148-09-5 Pregnan-20-one,... | CAS号6748-09-0 3-acetyloxy-3β-... | CAS号41767-48-0 (E)-2,2',3,3',4... | CAS号516-72-3 20Α-羟基胆固醇 | CAS号516-55-2 别孕烯醇酮 | CAS号17916-30-2 Pregn-5-en-20-o... | CAS号20976-92-5 20-methylpregn-... | CAS号1868-98-0 5a-Pregnan-20-o... | CAS号601-57-0 4-胆甾烯-3-酮

3Beta-羟基孕甾-5-烯-20-酮肟 3-乙酸酯置于三丁基膦,水,二苯二硫醚体系中,化学反应生成孕烯醇酮醋酸酯
参考文献:一种温和有效的方法,用于将肟还原为亚胺以进行进一步的原位反应
标题:一种温和有效的方法,用于将肟还原为亚胺以进行进一步的原位反应
摘要:三丁基膦-二苯基二硫化物是一种有效且温和的试剂,可将肟还原为亚胺.
Doi:10.1039/c39840000337

专利信息

专利号:WO-9419366-A1
优先权日:1993-02-26
标题 :Chemical synthesis of squalamine
发明人：MORIARTY ROBERT M; GUO LIANG; TULADHAR SUDERSAN M
权利人:MAGAININ PHARMA
摘要:Methods for the chemical preparation or synthesis of the sterol antibiotic squalamine. Preferably, the preparation is by modifying the 3-position of a 3-oxo-7α-hydroxy-24z-ether protected alcohol group-5α-cholestane with a spermidino moiety to form a 3β-spermidino-7α-hydroxy-24z-ether protected group -5α-cholestane; deprotecting the 24-position of the 3β-spermidino-7α-hydroxy-24z-ether protected group-5α-cholestane to the free hydroxyl; and sulfating the 24-position of the 3β-spermidino-7α, 24-dihydroxy-5α-cholestane.

专利号:US-3856780-A
优先权日:1973-06-18
标题 :Synthesis of 25-hydroxycholesterol and derivatives thereof
发明人：NARWID T; USKOKOVIC M
权利人:NARWID T; USKOKOVIC M
摘要:25-Hydroxycholesterol, an intermediate in the preparation of biologically important metabolites of Vitamin D3 is synthesized in a multi-step process from pregnenolone.

专利号:US-2012258938-A1
优先权日:2008-02-28
标题:Enzymatic Production or Chemical Synthesis and Uses for 5,7-Dienes and UVB Conversion Products Thereof
发明人：SLOMINSKI ANDREJ; TUCKEY ROBERT C; TANG EDITH; TIEU ELAINE; NGUYEN MINH; JANJETOVIC ZORICA; CHEN JIANJUN; LI WEI; LU YAN; MILLER DUANE D; ZJAWIONY JORDAN K; POSTLETHWAITE ARNOLD E
权利人:SLOMINSKI ANDREJ; TUCKEY ROBERT C; TANG EDITH; TIEU ELAINE; NGUYEN MINH; JANJETOVIC ZORICA; CHEN JIANJUN; LI WEI; LU YAN; MILLER DUANE D; ZJAWIONY JORDAN K; POSTLETHWAITE ARNOLD E
摘要:Provided herein are steroidal compounds that are androsta-5,7-dienes or pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof and cholecalciferol derivatives hydroxylated at one or more of C1, C17, C20, C23, C24, C25, and C26 which includes pharmaceutical, cosmeceutical or nutraceutical compositions of the steroidal compounds as shown in Tables 1A, 2A and 3. Also provided is a method for producing hydroxylated metabolites of cholecalciferol via CYP11A1, CYP24, CYP27A1, or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C1 or C20 or other position of the sidechain of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. Methods are provided for inhibiting proliferation of either a normally or abnormally proliferating cell, for modifying immune activity, or for treating a condition associated with the proliferating or quiescent cell or immune cells by contacting the cell with or administering any of the compounds described herein.

专利号:US-2014200201-A1
优先权日:2008-02-28
标题 :Enzymatic Production or Chemical Synthesis and Uses for 5,7-Dienes and UVB Conversion Products Thereof
发明人：SLOMINSKI ANDRZEJ T; TUCKEY ROBERT C; ZBYTEK BLAZEJ; ZMIJEWSKI MICHAL A; NGUYEN MINH NGOC; JANJETOVIC ZORICA; CHEN JIANJUN; LI WEI; MILLER DUANE D; ZJAWIONY JORDAN K; POSTLETHWAITE ARNOLD E; SWEATMAN TREVOR W
权利人:SLOMINSKI ANDRZEJ T; TUCKEY ROBERT C; ZBYTEK BLAZEJ; ZMIJEWSKI MICHAL A; NGUYEN MINH NGOC; JANJETOVIC ZORICA; CHEN JIANJUN; LI WEI; MILLER DUANE D; ZJAWIONY JORDAN K; POSTLETHWAITE ARNOLD E; SWEATMAN TREVOR W
摘要:Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds as shown in Tables 1 and 2. Also provided is a method for producing hydroxylated metabolites of cholecalciferol or ergocalciferol via the P450scc (CYP11A1) or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C20 of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. In addition, a method for inhibiting proliferation of either a normally or abnormally proliferating cell by contacting the cell with any of the compounds described herein. A related method is provided of treating a condition associated with the proliferating cell such as a cancer, a skin disorder, a defect in cell differentiation, cosmetic, prophylaxsis, or healthy cell maintenance.

专利号:US-2647909-A
优先权日:1950-06-26
标 题:Partial synthesis of pregnenolone
发明人：HEYL FREDERICK W; HERR MILTON E
权利人:UPJOHN CO

专利号:WO-2016103280-A1
优先权日:2014-12-23
标题 :Steroid-chitosan ketimine nanoparticles for antibacterial and antifungal activity
发明人：MONI DAS ARCHANA; AZIZ ALI ABDUL; KUMAR CHOWDHURY PRITISH; PROTIM HAZARIKA MANASH; YADAV ARCHANA; DEKA BHUYAN PURNAJYOTI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to the preparation of novel Steroid-Chitosan ketimine nanoparticles by one pot convenient process and determination of their Antibacterial and Antifungal Activities. This invention also relates to the synthesis of a new and novel class of Steroid-Chitosan Ketimine Nanoparticles starting from Pregnenolone Acetate and its analogs by convenient one pot method and their use as antibacterial and antifungal agents.