CAS: 1775-97-9; (E)-1-(2-Hydroxy-4,6-Dimethoxyphenyl)-3-Phenylprop-2-En-1-One

该化合物是一种天然化合物,被归类为一种香肠,是一种香肠,主要来自植物物种 *Kava* (Piper methysticaum),以其...

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(E)-3-Phenyl-1-(2,4,6-Trimethoxyphenyl)Prop-2-En-1-One 145629-35-2
2-羟基-4,6-二甲氧基苯乙酮 2-Hydroxy-4,6-Dimethoxyacetophenone 90-24-4
2,4,6-三甲氧基苯乙酮 1-(2,4,6-Trimethoxyphenyl)Ethanone 832-58-6
2,4,6-三羟基苯乙酮一水合物 2,4,6-Trihydroxyacetophenone 480-66-0

合成工艺路线路线简述

    📜2,4,6-三羟基苯乙酮一水合物置于potassium Carbonate,Potassium Hydroxide体系中,用 乙醇,丙酮 用作溶剂,化学反应 31.0H,反应生成(E)-1-(2-羟基-4,6-二甲氧基苯基)-3-苯基丙酮
    参考文献:通过主客体络合揭示 8-苯基-5,7-二羟基黄酮和 8-甲基-5,7-二羟基黄酮中的 6,8-重排
    标题:通过主客体络合揭示 8-苯基-5,7-二羟基黄酮和 8-甲基-5,7-二羟基黄酮中的 6,8-重排
    摘要:合成了 8-Phenyl-5,7-Dihydroxyflavylium 和 8-Methyl-5,7-Dihydroxyflavylium 以观察 6,8-重排.通过 8-碘黄素的 Suzuki-Miyaura 反应引入 8-苯基和 8-甲基残基,然后用 Lialh4 还原得到相应的 3-脱氧花色素.在 Ph 1.0 时,稳定形式是两种化合物中的 8-取代黄鎓阳离子.在较高的 Ph 值下,醌型碱是稳定的物种,并且获得了 6,8-重排的一些证据,但各自的光谱变化非常小.这可以通过使用改性环糊精(captisol)来克服,该环糊精有利于反式查耳酮的形成,而牺牲了醌型碱.将反式查耳酮分离并溶解在 Cd3Od/dcl (Pd < 1) 中,得到两种黄鎓异构体的混合物.这通过 HPLC 分离后两种异构体的 Esi-Ms 分析(以正离子模式记录)得到证实,得到相同的峰 ([m]+ M/z 253).6
    Doi:10.1002/ejoc.201701009

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    专利信息


    专利号:US-12036300-B2
    优先权日:2021-03-31
    标题:Methods and compositions for improving skin
    发明人：LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN
    权利人:OREAL
    摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.

    专利号:US-9061984-B2
    优先权日:2008-08-15
    标题 :Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases
    发明人：HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM
    权利人:HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM; UNIV LOUISVILLE RES FOUND; UNIV PERUMA CAYETANO HEREDIA; INST RECH POUR LE DÉVELOPPEMENT; UNIV JOHNS HOPKINS
    摘要:Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).

    专利号:CA-3111403-A1
    优先权日:2018-09-17
    标 题:Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease

    专利号:WO-2020061106-A4
    优先权日:2018-09-17
    标题:Matter of composition, synthesis, formulation and application of fl118 platform positions 7 and 9-derived analogues for treatment of human disease

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    主要参考文献


    1: Malami I, Muhammad A, Etti IC, Waziri PM, Alhassan AM. An in silico approach in predicting the possible mechanism involving restoration of wild-type p53 functions by small molecular weight compounds in tumor cells expressing R273H mutant p53. EXCLI J. 2017 Dec 8;16:1276-1287. doi: 10.17179/excli2017-299. eCollection 2017.
    2: Karimi-Sales E, Mohaddes G, Alipour MR. Chalcones as putative hepatoprotective agents: Preclinical evidence and molecular mechanisms. Pharmacol Res. 2017 Nov 23. pii: S1043-6618(17)31077-0. doi: 10.1016/j.phrs.2017.11.022. [Epub ahead of print] Review. doi: 10.1002/ptr.5891. Epub 2017 Aug 17. doi: 10.1007/s00204-017-1967-0. Epub 2017 Apr 3. doi: 10.1371/journal.pone.0173651. eCollection 2017.
    6: Thieury C, Lebouvier N, Le Guével R, Barguil Y, Herbette G, Antheaume C, Hnawia E, Asakawa Y, Nour M, Guillaudeux T. Mechanisms of action and structure-activity relationships of cytotoxic flavokawain derivatives. Bioorg Med Chem. 2017 Mar 15;25(6):1817-1829. doi: 10.1016/j.bmc.2017.01.049. Epub 2017 Feb 6. doi: 10.1371/journal.pone.0170233. eCollection 2017. Erratum in: PLoS One. 2017 Mar 7;12 (3):e0173651.

    合成参考文献


    摘要:Amador, A. G.; Scholz, S. O.; Skubi, K. L.; Yoon, T. P., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 479.
    参考文献:10.1107/s1600536810041395
    摘要:Sirat HM, Jani NA, Hazni H, Awang K, Ng SW. Flavokavain B from the rhizome of Alpinia mutica Roxb. Acta Crystallogr Sect E Struct Rep Online. 2010 Oct 20;66(Pt 11):o2866.
    参考文献:10.21873/anticanres.12520
    摘要:Lee JJ, Koh KN, Park CJ, Jang S, Im HJ, Kim N. The Combination of Flavokawain B and Daunorubicin Induces Apoptosis in Human Myeloid Leukemic Cells by Modifying NF-κB. Anticancer Res. 2018 May;38(5):2771–8. doi: 10.21873/anticanres.12520.
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