专利号:WO-2005051904-A2 优先权日:2003-10-23 标题 :Novel processes for the synthesis of cyclopropyl compounds
专利号:US-9670230-B2 优先权日:2012-11-29 标题 :Heteroaryl compounds and methods of use thereof 发明人:CAMPBELL JOHN EMMERSON; JONES PHILIP 权利人:SUNOVION PHARMACEUTICALS INC 摘要:Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.
专利号:US-2008187575-A1 优先权日:2004-08-27 标题:Pyrimidine Derivatives 发明人:KLEBL BERT; BAUMANN MATTHIAS; HOPPE EDMUND; BREHMER DIRK; DAUB HENRIK; KERI GYORGY; VARGA ZOLTAN; MAROSFALVI JENO; ORFI LASZLO 权利人:KLEBL BERT; BAUMANN MATTHIAS; HOPPE EDMUND; BREHMER DIRK; DAUB HENRIK; KERI GYORGY; VARGA ZOLTAN; MAROSFALVI JENO; ORFI LASZLO 摘要:The present invention relates to pyrimidine derivatives, methods for their synthesis, and the use of said pyrimidine derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of cell proliferation disorders, cancer, leukemia, erectile dysfunction, cardiovascular diseases and disorders, inflammatory diseases, transplant rejection, immunological diseases, neuroimmunological diseases, autoimmune diseases, infective diseases including opportunistic infections, prion diseases and/or neuro-degeneration. Furthermore, the present invention relates to pharmaceutical compositions containing at least one pyrimidine derivative and/or pharmaceutically acceptable salts thereof as an active ingredient together with at least one pharmaceutically acceptable carrier, excipient or diluents as well as to methods for prophylaxis and/or treatment of the above-mentioned diseases and disorders.
摘要:Kalyani, D.; Desai, L. V., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 739. 摘要:Baudoin, O., Science of Synthesis: Catalytic Transformations via CH Activation, (2014) 2, 59. 摘要:Walker, J. C. L., Science of Synthesis: Knowledge Updates, (2024) 3, 224. 摘要:Walker, J. C. L., Science of Synthesis: Knowledge Updates, (2024) 3, 210. 摘要:Walker, J. C. L., Science of Synthesis: Knowledge Updates, (2024) 3, 212.