CAS: 14948-96-0; N-((2S,3R,4R,5R,6R)-4,5-Dihydroxy-6-(Hydroxymethyl)-2-(4-Nitrophenoxy)Tetrahydro-2H-Pyran-3-yl)Acetamide

该化合物是一种染色体基质,广泛用于酶实验,特别是用于检测β-N-乙基甲基甲基甲酰胺酶活动.化合物在酶水解过程中释放p-nicrophotenol,允许在405纳米时进行光谱测量.它的高度纯度和特性使它适合于在遗传生物学,酶学和诊断应用方面的研究.基质在标准实验室条件下的稳定性确保动能研究和酶特征的可靠性能.它的结构相似性使得能够精确地模拟涉及N-acetycalactlogy-含甘基蛋白门的生物过程.该试剂具有一贯的再活性和低背景干扰价值,便于在学术和工业环境中进行精确测量.

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3459-18-5 23646-68-6 13089-27-5

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上下游产品

CAS号50271-51-7 dithieno[3,2-b,... | CAS号100-02-7 对硝基苯酚 | CAS号3068-34-6 2-乙酰氨基-3,4,6-三-...

合成工艺路线路线简述

    📜N-Nitrophenyl 2-Acetamido-3,4,6-Tri-O-Acetyl-2-Deoxy-β-D-Galactopyranoside置于甲醇,Sodium Methylate体系中,化学反应 0.5H,以100%的收率获得4-硝基苯基-N-乙酰-Beta-D-半乳胺
    参考文献:4-硝基苯基2-乙酰氨基-2-脱氧-β-D-葡萄糖和吡喃半乳糖苷的3-和4-硫代类似物的合成.
    标题:4-硝基苯基2-乙酰氨基-2-脱氧-β-D-葡萄糖和吡喃半乳糖苷的3-和4-硫代类似物的合成.
    摘要:描述了在生命系统中发现的两个主要的2-乙酰氨基-2-脱氧己糖的3-硫和4-硫类似物的4-硝基苯基β-糖苷的合成,Glcnac和galnac.虽然可以通过亲核取代磺酸衍生物与硫代乙酸酯来合成4-硫代类似物,但相邻基团乙酰胺基参与的问题使得必须将氨基磺酸酯中间体用于3-硫代类似物.这些3-和4-硫代类似物用于糖-氨基聚糖,糖蛋白和糖脂中存在的结构的硫代-寡糖类似物的化学-酶促合成中.
    Doi:10.1016/j.Carres.2007.05.023

    海关参考信息

    专利信息


    专利号:EP-0725144-A1
    优先权日:1995-02-06
    标题 :Process for the preparation of glycosides using glycosidases from ciliates
    发明人：KIY THOMAS DR; HOERSCH BRIGITTE DR; MARQUARDT RUEDIGER DR
    权利人:HOECHST AG
    摘要:The invention relates to a process for the production of glycosides by enzymatic glycosylation by means of α- and β-glycosidases from holotrich ciliates and in particular from Hymenostomatida.n n n Glycosidases from holotrich ciliates are very well suited for the enzymatic synthesis of alkyl glycosides, glycopeptides, di- or oligosaccharides. Preferred glycosyldoren are nitrophenylglycosides, glycosyl fluorides or disaccharides, preferred acceptors are short-chain alcohols, polyhydroxy compounds, in particular monosaccharides, or protected hydroxyamino acids or corresponding peptides.

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    主要参考文献

    [参考文献]: Edwards Rg, Et Al. The Purification And Properties Of A Beta-N-Acetylhexosaminidase From Trichomonas Foetus. Biochem J. 1975 Oct;151(1):145-8. Doi: 10.1042/bj1510145
    [参考文献]: E Kamst, Et Al. Chitin Oligosaccharide Synthesis By Rhizobia And Zebrafish Embryos Starts By Glycosyl Transfer To O4 Of The Reducing-Terminal Residue. Biochemistry. 1999 Mar 30;38(13):4045-52.
    [参考文献]: H De Boeck, Et Al. Binding Of Simple Carbohydrates And Some Of Their Chromophoric Derivatives To Soybean Agglutinin As Followed By Titrimetric Procedures And Stopped Flow Kinetics. J Biol Chem. 1984 Jun 10;259(11):7067-74.
    [参考文献]: Hong-Ming Chen, Et Al. Syntheses Of The 3- And 4-Thio Analogues Of 4-Nitrophenyl 2-Acetamido-2-Deoxy-Beta-D-Gluco- And Galactopyranoside. Carbohydr Res. 2007 Nov 5;342(15):2212-22.
    [参考文献]: I Pócsi, Et Al. Studies On The N-Acetyl-Beta-D-Hexosaminidase B From Germinating Lupinus Luteus L. Seeds. I. Purification And Characterization. Biochim Biophys Acta. 1990 May 31;1039(1):110-8.

    合成参考文献


    参考文献:10.1080/00021369.1991.10871049|10.1271/bbb1961.55.2817
    摘要:Koga K, Iwamoto Y, Sakamoto H, Hatano K, Sano M, Kato I. Purification and Characterization ofβ-N-Acetylhexosaminidase fromTrichoderma harzianum. Agricultural and Biological Chemistry. 1991 Nov;55(11):2817–23. doi: 10.1080/00021369.1991.10871049.
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