CAS: 1185-53-1; 2-Amino-2-(Hydroxymethyl)Propane-1,3-Diol Hydrochloride

相似化合物

6850-28-8 77-86-1 77-86-1

上下游产品

CAS号6000-43-7 甘氨酸盐酸盐 | CAS号74181-34-3 2,2-二甲基-1,3-二恶烷-5-酮 | CAS号53104-32-8 5-氨基-2,2-二甲基-1,... | CAS号51430-74-1 (5-amino-2-phen...

Cis-2,8-Diphenyl-5-Hydroxymethyl-1-Aza-3,7-Dioxabicyclo[3.3.0]octane置于盐酸体系中,用 甲醇 用作溶剂,化学反应 1.0H,以80%的收率获得三羟甲基氨基甲烷盐酸盐
参考文献:恶唑烷开环的立体电子控制:结构和化学证据
标题:恶唑烷开环的立体电子控制:结构和化学证据
摘要:研究了由三(羟甲基)氨基甲烷,L-丝氨酸和l-苏氨酸衍生的恶唑烷的开环.结果表明,在五元环中发生的n(n)->σ ∗(c-o)电子离域作用(内消旋作用)在环内c-O键的裂解中起主要作用.目前的工作表明,当氮孤对与羰基结合时(n(n)->π(co)离域),就像在n-酰基恶唑烷中发生的那样,水解和还原性开环都变得非常困难.氧碱性降低和环内c-O键强度升高的结果.
Doi:10.1016/s0040-4020(02)01287-5

专利信息

专利号:US-6683189-B1
优先权日:1996-02-26
标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
发明人：DERVAN PETER B; BAIRD ELDON
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

专利号:US-9512420-B2
优先权日:2013-10-16
标题:Use of N-acetylneuraminic acid aldolase in catalytic synthesis of N-acetylneuraminic acid
发明人：XIE JINGJING; JI WENYAN; YING HANJIE; Sun wujin; GUO TING; CHEN YONG; CHEN XIAOCHUN; WU JINGLAN
权利人:NANJING UNIV OF TECH; NANJING UNIVERSITY OF TECHNOLOGY
摘要:It discloses a use of N-acetylneuraminic acid aldolase with an amino acid sequence as shown in SEQ ID NO: 2 in catalytic synthesis of N-acetylneuraminic acid. The preparation of N-acetylneuraminic acid is to use the N-acetylneuraminic acid aldolase with the amino acid sequence as shown in SEQ ID NO: 2 as a catalyst, and N-acetylmannosamine and pyruvic acid as substrates.

专利号:US-5824472-A
优先权日:1986-03-24
标 题 :Process for the synthesis of sugar nucleotides using recombinant-DNA methods
发明人：BETLACH MICHAEL R; DOHERTY DANIEL H; VANDERSLICE REBECCA W
权利人:MONSANTO CO
摘要:A recombinant-DNA mediated method for the synthesis of sugar nucleotides is disclosed. This method utilizes portable DNA sequences capable of directing the microbial synthesis of various enzymes that catalyze the synthesis of sugar nucleotides, including UDP-glucose, UDP-glucuronic acid and GDP-mannose. The sugar moieties of these sugar nucleotides may subsequently be incorporated into industrially-useful polysaccharides such as xanthan gum. It has been found that vectors containing the portable DNA sequences described herein are capable both of causing sugar nucleotide production in microorganisms previously incapable of such synthesis and of causing increased sugar nucleotide production in organisms capable of synthesizing small quantities of these compounds. In particular, plasmids pAS7, pAS9 and pTS13 are disclosed. These plasmids are capable of directing sugar nucleotide synthesis in various hosts, including Xanthomonas sp. such as X. campestris and other organisms such as E. coli and various Pseudomonas sp.

专利号:US-2012058520-A1
优先权日:2009-05-14
标 题:Method for synthesis of double-stranded dna corresponding to rna, and method for amplification of the dna
发明人：HAYASHIDA YUKINOBU
权利人:HAYASHIDA YUKINOBU; WAKO PURE CHEM IND LTD
摘要:An object of the present invention is to provide an inexpensive and simple method for synthesis of a double-stranded DNA corresponding to a particular RNA, and a method for amplification of the aforementioned double-stranded DNA. The present invention relates to a method for synthesis of a double-stranded DNA having a nucleotide sequence corresponding to template RNA having polyA, comprising step 1 in which reverse transcription reaction of template RNA is carried out employing oligo(dT)primer to which DNA fragment having a known sequence has been added at the 5′-terminal, to obtain a single-stranded DNA, and step 2 in which double strand formation reaction of single-stranded DNA obtained in step 1 is carried out employing a random primer to which DNA fragment having a known sequence has been added at the 5′-terminal, in the presence of polymerase which does not have 3′→5′ exonuclease activity nor strand displacement activity, to obtain a double-stranded DNA, as well as a method for amplification of a double-stranded DNA having a nucleotide sequence corresponding to template RNA having polyA, further comprising step 3 in which PCR reaction is carried out using the obtained double-stranded DNA.

专利号:WO-2024199310-A1
优先权日:2023-03-31
标 题 :Method for enzymatic synthesis of capped mrna in one tube
发明人：LI YALI; ZHU HUAXING; ZHANG QINGYI
权利人:NOVOPROTEIN SCIENT INC
摘要:Provided is a method for enzymatic synthesis of capped mRNA in one tube. In the method, the step of purifying mRNA after IVT is omitted, and a capped product having a higher capping efficiency and fewer by-products is obtained. The method provided for enzymatic synthesis of capped mRNA is simple, convenient and short in terms of the process, and is rapid and efficient, so that the production process of a capped mRNA product is simplified, and a production cost is reduced, which is conducive to industrial production.

专利号:US-5112734-A
优先权日:1989-05-26
标 题 :Target-dependent synthesis of an artificial gene for the synthesis of a replicatable rna
发明人：KRAMER FRED R; LIZARDI PAUL M
权利人:GENE TRAK SYSTEMS
摘要:This invention pertains to an improved method for detecting a nucleic acid target sequence with a replicatable RNA reporter system. Two polymerase-mediated reactions are used to generate a target-specific gene containing a DNA sequence for a replicatable RNA. Transcription of the target-specific gene yields a replicatable RNA which is amplified by replication. Synthesis of the gene and the replicatable RNA is strictly dependent upon specific interaction with the target sequence. Consequently, the amplified signal (RNA) is target-dependent and background signal is reduced.