CAS: 1086026-31-4; (S)-3-(3-(((3,4-Dimethoxybicyclo[4.2.0]Octa-1,3,5-Trien-7-yl)Methyl)(Methyl)Amino)Propyl)-7,8-Dimethoxy-1H-Benzo[d]Azepin-2(3H)-One

上下游产品

[{(7S)-3,4-dimethoxybicyclo[4.2.0]°Cta-1,3,5-trien-7-yl}methyl](methyl)amine 7,8-dimethoxy-3-[3-iodopropane]-1,3-dihydro-2H-3-benzazepin-2-one 3-{3-[[(3,4-Dimethoxybicyclo[4.2.0]°Cta-1,3,5-trien-7-yl)methyl]-(methyl)amino]propyl}-7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 1-[(7S)-3,4-dimethoxybicyclo[4.2.0]°Cta-1,3,5-trien-7-yl]-N-methylmethanamine hydr°Chloride ivabradine ivabradine hydr°Chloride

Ethyl ((3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-Trien-7-yl)Methyl)Carbamate置于lithium Aluminium Tetrahydride,Sodium Hydroxide体系中,用 四氢呋喃,乙醇,乙酸乙酯 用作溶剂,化学反应 19.5H,反应生成去氢伊伐布雷定
参考文献:Process For The Synthesis Of (2E)-3-(3,4-Dimethoxyphenyl)Prop-2-Enenitrile,And Application In The Synthesis Of Ivabradine And Addition Salts Thereof With A Pharmaceutically Acceptable Acid
标题:Process For The Synthesis Of (2E)-3-(3,4-Dimethoxyphenyl)Prop-2-Enenitrile,And Application In The Synthesis Of Ivabradine And Addition Salts Thereof With A Pharmaceutically Acceptable Acid
摘要:化合物(i)的合成过程:在伊维布地定的合成中的应用,以及其与药用可接受酸的加合盐和水合物.

专利信息

专利号:US-8927708-B2
优先权日:2013-03-26
标 题 :Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine
发明人：LE FLOHIC ALEXANDRE
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nwherein R represents a para-methoxybenzyl (PMB) group or the following group:n n nApplication in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

专利号:US-8779122-B2
优先权日:2012-11-08
标 题:Process for the synthesis of (2E)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:WO-2019202611-A1
优先权日:2018-04-21
标题:An improved process for the synthesis of ivabradine and its pharmaceutically acceptable salts
发明人：NANDEPU Venkateswara Rao; BOPPANA DURGA PRASAD
权利人:METROCHEM API PVT
摘要:: Disclosed herein is an improved process for the preparation of Ivabradine and pharmaceutically acceptable salts thereof. The invention more particularly disclosesthe synthesis of key intermediates viz.,(S)-N-[(4,5-dimethoxybenzocydobut-l-yl)-methyl]-N- (methyl)amine hydrochloride of Formula-II and 3-(3-Iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzapin-2-one of Formula-III, and its use in industrial synthesis of Ivabradine and pharmaceutically acceptable salts thereof.

专利号:US-8859763-B1
优先权日:2013-05-17
标题 :Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：VAYSSE-LUDOT LUCILE; LE FLOHIC ALEXANDRE; VAULTIER MICHEL; PUCHEAULT MATHIEU; KAMINSKI THOMAS
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-8779123-B2
优先权日:2012-12-06
标题:Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-8779121-B2
优先权日:2012-10-12
标题:Process for the synthesis of 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：CARRANZA MARIA DEL PILAR; GARCIA ARANDA MARIA ISABEL; GONZALEZ JOSÉ LORENZO; SANCHEZ FRÉDÉRIC
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n nApplication in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.