CAS: 1012-12-0; 4-[(Trimethylsilyl)Oxy]Benzaldehyde

相似化合物

1529-17-5 96013-95-5 84678-74-0

上下游产品

chloro-trimethyl-silane 4-hydroxy-benzaldehyde N,O-bis-(trimethylsilyl)-acetamide N-methyl-N-trimethylsilyl-2,2,2-trifluoroacetamide methyl 3-hydroxy-3-(p-hydroxyphenyl)propionate GA-1 4-[hydroxy-(4-vinyl-phenyl)-methyl]-phenol 3-hydroxy-3-(4-trimethylsilanyloxy-phenyl)-propionic acid benzyl ester

📜对羟基苯甲醛置于三甲基氯硅烷,三乙胺体系中,化学反应生成4-三甲基硅氧苯甲醛
参考文献:4-Aryl-And 4-Arylthio-5-Hydroxy-2(5H)-Furanones As Inhibitors Of
标题:4-Aryl-And 4-Arylthio-5-Hydroxy-2(5H)-Furanones As Inhibitors Of
摘要:本发明提供了以下结构的新型5-羟基-4-芳基-和5-羟基-4-(芳硫基)-2(5H)-呋喃酮:其中r含有约五至约二十个碳原子并在此处定义;X是氧,硫,So.Sub.2,Nh,N(较低烷基),N(较低酰基),氨基甲酰,甲酰,甲酰氨基,Ch.Sub.2或碳-碳键;Y是氢,卤素,较低烷基,硝基,烷基硫,全氟烷基,羟基或较低烷氧基(C.Sub.1-C.Sub.8);Z是硫或碳-碳键;Q是h,由1-20个碳原子组成的烷基,Cor',Coor',Conhr',Po(Or')2,Po(Or')R",其中r'和r"分别独立选择自h,由1-20个碳原子组成的烷基,苯基和取代苯基及其前药和其药用盐.还提供了包含这些化合物的制药组合物,使用这些化合物作为炎症抑制剂和用于治疗由花生四烯酸代谢产物过度产生所表征的其他疾病的方法,以及制备这些化合物的中间体和方法.

专利信息

专利号:WO-9417080-A1
优先权日:1993-01-26
标 题:Rhodium catalyzed silaformylation of aldehydes and products obtained therefrom
发明人：WRIGHT MICHAEL E
权利人:UNIV UTAH STATE
摘要:Aldehydes substituted with carbon radicals such as alkyl, aromatic, and heterocyclic, can be silaformylated with a silane reagent and carbon monoxide in the presence of rhodium catalyst to produce alpha-silyloxyaldehydes. The alpha-silyloxyaldehydes are useful intermediates in the synthesis of biologically active molecules.