CAS: 997-55-7; Acetyl-L-Aspartic Acid

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2545-40-6 284665-15-2 369-08-4

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CAS号5269-42-1 L-Aspartic acid... | CAS号75-36-5 乙酰氯 | CAS号41148-79-2 N-(2,5-二氧代氧杂戊环-... | CAS号56-84-8 L-天门冬氨酸 | CAS号108-24-7 乙酸酐 | CAS号19146-51-1 (S)-N-Acetylami... | CAS号3106-85-2 异冬谷酸 | CAS号17336-14-0 2-乙酰氧基-5-硝基苯甲酸 | CAS号1734-62-9 2-(乙酰氧基)-5-氯苯甲酸 | CAS号50-78-2 阿司匹林 | CAS号41148-79-2 N-(2,5-二氧代氧杂戊环-... | CAS号56-84-8 L-天门冬氨酸

(S)-N-乙酰氨基丁酸置于hydrogen Peroxide,三氟乙酸体系中,用 Water-D2 作为反应溶剂,化学反应生成 N-乙酰-L-天门冬氨酸
参考文献:从激进的角度看氨基酸和肽的特殊稳定性
标题:从激进的角度看氨基酸和肽的特殊稳定性
摘要:游离和 N-乙酰α-氨基酸与氯和氘标记的过氧化氢的光化学反应已被用于确定这些类别分子的相对反应速率以及它们不同类型的氢对氯和氢的提取的相对反应性.以氧为中心的自由基.这些物种的相对反应速率范围超过 3 个数量级;然而,对于侧链特定位置上特定类型基团的多个氨基酸的数据,这些值非常相似.这些结果的预测效用已被证明用于三肽的区域选择性氯化.更一般地说,该分析表明氨基酸和肽的主链和相邻侧链位置对氢原子转移具有特殊的抵抗力,并且在异青霉素-N-合成酶催化的修饰底物反应的早期研究中已经注意到类似的反应模式. 这种抗性与 α-氨基酸,肽和蛋白质的自由基反应的常见发生及其在生物学中的重要性形成鲜明对比.然而,它为氨基酸及其衍生物在自然界中避免降解的能力提供了一个理由,因为它们经常暴露于自由基,并且它至少部分地解释了酶催化自由基反应的异常能力而不是被自由基中间体分解.在异青霉素-N-合成酶催化的修饰底物反应
DOI:10.1021/ja9027583

专利信息

专利号:US-4314939-A
优先权日:1979-07-13
标题 :Process for the preparation of 15-hydroxyimino-E-homoeburnane and intermediates therefor
发明人：SZANTAY CSABA; SZABO LAJOS; KALAUS GYOERGY; DANCSI LAJOS; KEVE TIBOR; DREXLER FERENC
权利人:RICHTER GEDEON VEGYESZET
摘要:A process for the preparation of 15-hydroxyimino-E-homoeburnane derivatives of the formula (I), ##STR1## wherein X 1 stands for hydrogen or halogen and n R is a C 1-6 alkyl group, n or acid addition salts and optically active derivatives thereof. These compounds are valuable intermediates of the synthesis of compounds with outstanding biological effects. According to the invention a racemic or optically active 15-hydroxy-E-homoeburnane derivative of the formula (II), ##STR2## is treated, optionally after separating the 15-epimers and/or resolution, with a halogenating agent. The resulting 15-halo-E-homoeburnane derivative of the formula (III), ##STR3## wherein X 2 stands for halogen, is reacted, optionally after separating the 15 epimers and/or resolution, with an alkali nitrite in the presence of an acid, and, if desired, the resulting 15-hydroxyimino-E-homoeburnane derivative of the formula (I) is converted into its acid addition salt and/or resolved. The compounds of the formula (III) formed as intermediates in the above process are new and biologically active.

专利号:US-2024400861-A1
优先权日:2021-10-01
标题 :Triazole- And/Or Triazolium-Based Polymers And Copolymers As Additives For Chemical Mechanical Planarization Slurries
发明人：LARBIG GREGOR; KIRSCH PEER; HENGST MATTHIAS; SHI XIAOBO; STENDER MATTHIAS
权利人:VERSUM MAT US LLC
摘要:Synthesis of triazole- and/or triazolium-based polymers is disclosed. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising triazole- and/or triazolium-based polymers; and water. The use of the synthesized triazole- and/or triazolium-based polymers in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.

专利号:WO-9209300-A1
优先权日:1990-11-21
标 题:Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures

专利号:US-10253061-B2
优先权日:2014-10-10
标 题:Peptide fragment condensation and cyclisation using a subtilisin variant with improved synthesis over hydrolysis ratio
发明人：QUAEDFLIEG PETER JAN LEONARD MARIO; NUIJENS TIMO; VAN DER LAAN JAN METSKE; JANSSEN DIRK BAREND; TOPLAK ANA; WU BIAN
权利人:ENZYPEP B V
摘要:The invention relates to a method for enzymatically synthesizing an (oligo)peptide, comprising coupling (a) an (oligo)peptide C-terminal ester or thioester and (b) an (oligo)peptide nucleophile having an N-terminally unprotected amine,n wherein the coupling is carried out in a fluid comprising water, and wherein the coupling is catalyzed by a subtilisin BPN′ variant or a homolog thereof, which comprises the following mutations compared to subtilisin BPN′ represented by SEQUENCE ID NO: 2 or a homolog sequence thereof:n a deletion of the amino acids corresponding to positions 75-83; a mutation at the amino acid position corresponding to S221, the mutation being S221C or S221 selenocysteine; n preferably a mutation at the amino acid position corresponding to P225 wherein the amino acid positions are defined according to the sequence of subtilisin BPN′ represented by SEQUENCE ID NO: 2. nn Further, the invention relates to an enzyme suitable for use as a catalyst in a method of the invention.

专利号:WO-2024073211-A1
优先权日:2022-09-29
标题:Guanidinium-based polyionic liquids and their use as additives for chemical mechanical planarization slurries
发明人：LARBIG GREGOR; KIRSCH PEER; SHI XIAOBO
权利人:VERSUM MAT US LLC
摘要:Synthesis of guanidinium-based polymers is disclosed. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising guanidinium-based polymers; and water. The use of the synthesized guanidinium-based polymers in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.

专利号:US-2025215130-A1
优先权日:2022-04-11
标 题:Polycationic Polymer Or Copolymer Having Different Cation Types For Slurries In Chemical Mechanical Planarization
发明人：LARBIG GREGOR; SHI XIAOBO
权利人:MERCK PATENT GMBH; VERSUM MAT US LLC
摘要:Synthesis of polycationic polymer or copolymer is disclosed. The polycationic polymer or copolymer are formed by at least one first cationic monomer and at least one second cationic monomer wherein the first cationic monomer and the second cationic monomer have different cationic groups; such as imidazolium group and non-imidazolium group. Chemical Mechanical Planarization (CMP) slurries comprise abrasives; activator; oxidizing agent; additive comprising polycationic polymer or copolymer; and water are also disclosed. The use of the synthesized polycationic polymer or copolymer in the CMP slurries reduces dishing and erosion in highly selective tungsten slurries.