CAS: 893631-08-8; 6-Hydrazinylpyrimidine-2,4(1H,3H)-Dione
该化合物是一种三环化合物,其特点是以和Keto功能组取代了一种火水晶核核心,这种结构在制药和农用化学合成中赋予了反活性作用,特别是作为制造更复杂的分子的多用途中间体,它的氢氰基化合物组可以产生凝结反应,而二体细胞组则提供进一步功能化的场所.该化合物在标准条件下的稳定性有利于处理和储存.该化合物常常被用于开发核核糖类和其他生物活性衍生物,利用其参与循环和组合反应的能力.对于研究规模的应用来说,它提供了医药化学和材料科学的可靠建筑块.
相似化合物
1142201-78-2 6312-73-8 4805-72-5物理性质
MSDS等安全信息
合成工艺路线路线简述
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Synthesis Of Pyrimido [4,5-C] Pyridazine (4-Deazafervenulin), Pyrazolo[3,4-D] Pyrimidine And 6-(Pyrazino-1-Yl)Pyrimidine Derivatives作者:Vishnu J. Ram,Hrishi Kesh Pandey,Arnold J. Vlietinck |发布日期:1980.9
摘要:The Synthesis Of Several Pyrimido[4,5-C]Pyridazine (4-Deazafervenulin) (1), Pyrazolo[3,4-D]-Pyrimidine (2) And 6-(Pyrazino-1-Yl)Pyrimidine (9) Analogs Has Been Accomplished From 6-Hydrazinouracil (3). This Compound Could Not Be Used As Starting Material For The Preparation Of Indolo[3,2-C]Pyridazino[3,4-D]Pyrimidine Derivatives (8) Because It Yielded The Corresponding Hydrazones (7).
合成参考文献
参考文献:10.1023/b:rujo.0000034935.21006.ed
摘要:Moskvin AV, Reznikova NR, Ivin BA. Hydroxypyrimidines Condensation with Carbonyl Compounds: II. Hydroxy-, Sulfanyl-, and Aminopyrimidines. Russian Journal of Organic Chemistry. 2004 Feb;40(2):143–61. doi: 10.1023/b:rujo.0000034935.21006.ed.
参考文献:10.1186/s13065-018-0424-3
摘要:El-Kalyoubi SA. Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent. Chemistry Central Journal. 2018 May 23;12(1). doi: 10.1186/s13065-018-0424-3.
参考文献:10.1021/jm00219a014
摘要:Wright GE, Brown NC. Inhibitors of Bacillus subtilis DNA polymerase III. Structure-activity relationships of 6-(phenylhydrazino)uracils. J Med Chem. 1977 Sep;20(9):1181–5. doi: 10.1021/jm00219a014.
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