CAS: 78-11-5; Pentaerythritol Tetranitrate

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CAS号115-77-5 季戊四醇 | CAS号6228-26-8 2,2’-[亚甲基双(氧亚甲基... | CAS号74999-16-9 1,2-bis-nitrylo... | CAS号76-02-8 三氯乙酰氯 | CAS号7664-93-9 硫酸 | CAS号3710-84-7 N,N-二乙基羟胺(DEHA) | CAS号1607-17-6 戊硝醇 | CAS号109985-28-6 dipotassium sal... | CAS号109985-30-0 dicesium salt o... | CAS号109985-29-7 dirubidium salt... | CAS号109985-32-2 dipotassium sal... | CAS号109985-34-4 dicesium salt o... | CAS号109985-33-3 dirubidium salt... | CAS号109972-56-7 dirubidium salt... | CAS号109972-57-8 dicesium salt o...

📜2,2'-[亚甲基双(氧亚甲基)]双[2-羟甲基]-1,3-丙二醇置于硝酸体系中,化学反应生成 季戊四醇四硝酸酯
参考文献:Werle,Peter; Nonnenmacher,Gerhard; Kruse,Karsten,Liebigs Annalen Der Chemie,1980,# 6,P. 938-945
标题:Werle,Peter; Nonnenmacher,Gerhard; Kruse,Karsten,Liebigs Annalen Der Chemie,1980,# 6,P. 938-945

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-10801022-B2
优先权日:2015-04-14
标 题:Method for solid-phase synthesis of DNA encoded compound library
发明人：LI JIN; Wan jinqiao; LIU GUANSAI; DOU DENGFENG
权利人:HITGEN LTD; HITGEN INC
摘要:The present invention provides a method of solid-phase synthesis of DNA-encoded compound library. The method includes following steps: a) reacting solid carrier G-1 with linker molecule L-1 to prepare L-G-1; b) reacting DNA with linker molecule L-0 to prepare L-2; c) reacting L-G-1 with L-2 to prepare L-G-2; d) removing protection group of the L-G-2 and obtaining L-G-2-1; e) reacting the L-G-2-1 with synthetic building block and performing DNA encoding; and f) removing the solid carrier and obtaining the DNA-encoded compound library. Compared with the prior art, the present invention can complete post-treatment purification of the reaction only by filtration and irrigation processes for several times. The present invention is simple to operate, can shorten the production cycle of DNA encoded compound library with more than 50%, significantly increases the production efficiency and the unicity as well as the purity of the final products.

专利号:WO-03064360-A1
优先权日:2002-02-01
标 题:Synthetic tetraethers and synthesis strategies therefor
发明人：KUEHL CHRISTINE; LITTGER RALF
权利人:BERNINA BIOSYSTEMS GMBH; KUEHL CHRISTINE; LITTGER RALF
摘要:The invention relates to novel synthetic tetraethers and a novel method for producing said substances. The inventive tetraethers are characterised in that they can be modified in a simple and targeted manner according to said synthesis method, which enabling the synthesis of the desired model substances. The synthesis concept guarantees high variability with simple individual production.

专利号:US-2009311292-A1
优先权日:2006-09-14
标题:Process for synthesis and incorporation of nitric oxide donors in macromolecular compositions
发明人：PACHECO OGARI; MOREIRA ROBERTO; SEABRA AMEDEA; SOUZA GABRIELA; OLIVEIRA MARCELO
权利人:CRISTALIA PROD QUIMICOS FARM; UNIV ESTADUAL DE CAMPINASUNICA
摘要:The present invention describes a process for the synthesis of S-nitrosothiols and the subsequent incorporation of these compounds in hydrophilic macromolecular compositions. By the process described herein, the S-nitrosothiols are synthesized in a device (FIG. 2 ) in a first step from the S-nitrosation reaction of their respective precursor thiols (A), promoted by a mechanical action that puts the thiols in contact with the nitrous acid formed from nitrite anions in acidic medium (B), and in a second mechanical operation, the freshly formed S-nitrosothiols are incorporated in an application vehicle (C) based on hydrophilic macromolecular compositions that increases their thermal stability. Therefore, the process under consideration combine the pre-application synthesis of S-nitrosothiols with their subsequent incorporation in delivery vehicles, with provide a relative stabilization of the S-nitrosothiols for sufficient periods so that the formulations prepared by this process may be stored in a domestic refrigerator during its time of use in its several possible applications.

专利号:WO-2025037082-A1
优先权日:2023-08-11
标题:Improved flow synthesis
发明人：MCWHIR NAIL; KENNEDY STUART; JONES CHRISTOPHER; DIDSBURY MATTHEW PAUL; JUBB DANIEL; THOMAS SIMON DAVID; MURRAY IAN EWART PATTERSON
权利人:BAE SYSTEMS PLC
摘要:The invention relates to a method for the flow synthesis manufacture of energetic materials with a two stage-temperature reactor. There is provided a flow reactor for the synthesis of energetic materials, comprising; i. a first input flow reagent, and a second input flow reagent ii. a flow reactor, comprising at least two temperature zones within the reactor. (Formula (I))

专利号:WO-2008031182-A1
优先权日:2006-09-14
标 题 :Process for synthesis and incorporation of nitric oxide donors in macromolecular compositions
发明人：PACHECO OGARI; MOREIRA ROBERTO; SEABRA AMEDEA; SOUZA GABRIELA; OLIVEIRA MARCELO
权利人:CRISTALIA PROD QUIMICOS FARM; UNICAMP; PACHECO OGARI; MOREIRA ROBERTO; SEABRA AMEDEA; SOUZA GABRIELA; OLIVEIRA MARCELO
摘要:The present invention describes a device and a process for extemporaneous synthesis and incorporation of a s-nitrosothiol in a hydrophilic macromolecular composition resulting in a. topical S-nitrosothiol pharmaceutical composition, said, device constituted by a reaction compartment (5) or (12) containing an acid aqueous solution; a storage compartment [(1)+ (3)] and. [(2) + (4)] or (11) containing a nitrosable thiol, or an acid salt of the nitrosable thiol, and a nitrite salt, both in the solid form, separated from each other or in a mixture; and a formulation compartment (6) or (13) containing a hydrophilic macramolecular composition, which may be either coupled to or uncoupled from the reaction compartment, and said device being used in a process that combine the extemporaneous synthesis of a S-nitrosothiol with the incorporation of the extemporaneously synthesized S- nitrosothiol in a hydrophilic macromolecular composition immediately prior to the topical application of the resulting composition to a patient.