异丙基氯化镁置于四氯化硅体系中,用 四氢呋喃,甲苯 作为反应溶剂,化学反应 5.0H,反应生成 二异丙基二氯硅烷 参考文献:Production Processes For Triorganomonoalkoxysilanes And Triorganomonochlorosilanes 标题:Production Processes For Triorganomonoalkoxysilanes And Triorganomonochlorosilanes 摘要:含有庞大烃基或基团r的硅烷,其具有式(Iii)R3-(X+y)(R1)X(R2)Ysi(Or3),可通过反应式(I)(R1)X(R2)Ysicl3-(X+y)(Or3)的硅烷与式(II)Rmgx的格氏试剂制得.此外,式(Xiia)(R1)(R2)(R3)Sicl的三有机氯硅烷可通过反应式(Xia)(R1)(R2)(R3)Siz1的三有机硅烷与盐酸制得.再者,当式(Xxi)(R1)X(R2)Ysicl4-(X+y)的硅烷与式(Xxii)Rmgx的格氏试剂反应,并在反应过程中加入并反应酒精或环氧化合物时,可制得式(Xxiii)R3-(X+y)(R1)X(R2)Ysi(Or3)的三有机单烷氧基硅烷.
专利信息
专利号:US-6242614-B1 优先权日:1999-05-28 标 题:Semi-synthesis of paclitaxel using dialkyldichlorosilanes 发明人:VEMISHETTI PURUSHOTHAM; GIBSON FRANCIS S; DILLON JOHN L 权利人:BRISTOL MYERS SQUIBB CO 摘要:A process for the synthesis of paclitaxel from 10-deacetylbaccatin-III which is protected at the 7-position with a dialkylalkoxysilyl protecting group having the formula —Si(R) 2 (OR′).
专利号:US-6180718-B1 优先权日:1996-03-01 标题:Process for preparation of aromatic and heteroaromatic molecules 发明人:BOEHM TERRI L; HODGES JOHN C; SHOWALTER HOWARD D H 权利人:WARNER LAMBERT CO 摘要:A process for the attachment of aromatic or heteroaromatic rings to a polymeric support via a silyl ether linkage is described. Such process involves the synthesis of a chlorodialkyl aryl or heteroarylsilane which is then coupled to a polymeric support via a hydroxyl functionality to form a polymer-bound silyl ether. Further modification provides a polymer-bound small organic molecule that is cleaved from the polymeric support under mild conditions to give an aryl or heteroaryl silanol or a compound in which the aryl or heteroaryl carbon-silicon bond is replaced with a carbon-hydrogen, carbon-halogen, carbon-hydroxyl, carbon-sulfur, or carbon—carbon bond. Such methods are useful for the preparation of a library of diverse aromatic and heteroaromatic compounds by both manual and automated synthesis.
专利号:US-11691883-B2 优先权日:2018-09-10 标题:Synthesis of trichlorosilane from tetrachlorosilane and hydridosilanes 发明人:AUNER NORBERT; STURM ALEXANDER G 权利人:MOMENTIVE PERFORMANCE MAT INC 摘要:The invention relates to a process for the preparation of trichlorosilane (HSiCl3) which comprises the reaction of tetrachlorosilane (SiCU) with hydridosilanes in the presence of a catalyst.
专利号:EP-1391459-A1 优先权日:1999-08-11 标 题:Process for the preparation of a paclitaxel C-4 methyl carbonate analog and intermediates 发明人:KANT JOYDEEP 权利人:BRISTOL MYERS SQUIBB CO 摘要:A process for the synthesis of a C-4 methyl carbonate paclitaxel analog from 10-deacetylbaccatinnIII by the selective reduction of the acetate at the C-4 position ofn10-deacetylbaccatin using Red-Al.
专利号:US-12384803-B2 优先权日:2020-02-24 标 题:Non-cryogenic synthesis of heteroatom-bridge precursors of metal-ligand complex catalysts 发明人:DO HIEN Q; FONTAINE PHILIP P; KRASOVSKIY ARKADY L; SPENCER LIAM P; OGAWA KELLI A; LESNIEWSKI DANIEL K; ANDERSON RUSSELL W 权利人:DOW GLOBAL TECHNOLOGIES LLC 摘要:Embodiments are directed to a metal-ligand complex catalyst precursor, (L1)(L2)X(R1)(R2), and methods for producing the same from a compound of formula Q2X(R1)(R2). L1 and L2 are independently —R3—Z1 or —R4—Z1. R1 and R2 are independently selected from a hydrogen atom, (C1-C40)hydrocarbyl and, optionally, R1 and R2 are connected to form a ring having from 3 to 50 atoms in the ring, excluding hydrogen atoms. X is Si, Ge, Sn, or Pb. Each Q is independently Ar1—Y1R3— or Ar2—Y2—R4—. R3 and R4 are independently selected from —(CRC2)m—, where m is 1 or 2, and where each RC is independently selected from the group consisting of (C1-C40)hydrocarbyl, (C1-C40)heterohydrocarbyl, and —H. Y1 and Y2 are independently S, Se, or Te. Ar1 and Ar2 are independently (C6-C50)aryl. Ar1—Y1—R3— and Ar2—Y2—R4— are not identical. Each Z1 is independently selected from Cl, Br, and I.
专利号:US-6353120-B2 优先权日:1999-08-11 标 题:Process for the preparation of a paclitaxel C-4 methyl carbonate analog 发明人:KANT JOYDEEP 权利人:BRISTOL MYERS SQUIBB CO 摘要:A process for the synthesis of a C-4 methyl carbonate paclitaxel analog from 10-deacetylbaccatin III by the selective reduction of the acetate at the C-4 position of 10-deacetylbaccatin using Red-Al.
参考标题:Palladium‐catalyzed Synthesis Of Benzophenanthrosilines By C−h/c−h Coupling Through 1,4‐palladium Migration/alkene Stereoisomerization 作者:Tomohiro Tsuda,Yuka Kawakami,Seung‐min Choi,Ryo Shintani |发布日期:2020.5.18 摘要:Catalysis. The Reaction Mechanism Has Been Experimentally Investigated And A Catalytic Cycle Involving A C-H/c-H Coupling Through A New Mode Of 1,4-Palladium Migration With Concomitant Alkene Stereoisomerization Has Been Proposed.
合成参考文献
摘要:Skrydstrup, T., Science of Synthesis, (2002) 4, 271.