CAS: 70424-68-9; 2,3,3',4',5-Pentachlorobiphenyl
该化合物是多氯联苯(PCB)家族的成员,这些是合成有机化学品,以其环境持久性和潜在毒性而著称;该化合物有五个氯原子,代之以双苯结构,特别是2,3,3',4'和5个位置;其物理特性包括水中的高熔点和低溶解性,这有利于其环境的稳定性和生物累积性. 2,3',3',4',5-五溴二苯醚主要用于工业用途,尽管由于担心其对人类健康和生态系统的有害影响,许多国家已严格限制或禁止其生产和使用;已知该化合物具有内分泌干扰特性,并且与包括癌症和发展问题在内的各种有害健康影响相关联;目前正在开展监测和补救工作,以解决包括这一特定化合物在内的多氯联苯污染环境的问题.
- 英文名称2,3,3',4',5-Pentachlorobiphenyl
- 中文名称2,3,3',4',5-五氯联苯
- IUPAC名称1,2,5-trichloro-3-(3,4-dichlorophenyl)benzene
- 其它别名2,3,3',4',5-PENTACHLOROBIPHENYL; 2,3,3',4',5-Pentachloro-1,1'-biphenyl
- CAS编号70424-68-9
- MFCD编号:MFCD00792644
- FDA UNII编号:TL37H89TCR
- 分子式:C12H5Cl5分子量:326.43
- 产品CID: 1698136
- 产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃
- 相似结构搜索
- 产品信息参考
;;;; - InChIKey: PVYBHVJTMRRXLG-UHFFFAOYSA-N
- 1S/C12H5Cl5/c13-7-4-8(12(17)11(16)5-7)6-1-2-9(14)10(15)3-6/h1-5H
- 计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0
MSDS等安全信息
- 危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website. - 安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)
上下游产品
3,4-dichloroiodobenzene 1,2,5-trichloro-3-iodobenzene 3,4-dichlophenylboronic acid m,p-dichloroaniline合成工艺路线路线简述
- 合成目标产物 2,3,3',4',5-Pentachlorobiphenyl 主要起始原料 1-Iodo-2,3,5-Trichlorobenzene And 3,4-Dichlorophenylboronic Acid
- (文献来源)合成步骤主要原料 1-Iodo-2,3,5-Trichlorobenzene 和 3,4-Dichlorophenylboronic Acid
📜3,4-二氯碘苯,1-碘-2,3,5-三氯苯置于铜体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应生成 2,3,3',4',5-五氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4
海关参考信息
- 2903911000-邻二氯苯
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Synthesis Of Polychlorinated Biphenyls And Their Metabolites With A Modified Suzuki-Coupling作者:Izabela Kania-Korwel,Sean Parkin,Larry W Robertson,Hans-Joachim Lehmler |发布日期:2004.8
摘要:A Modified Procedure For The Synthesis Of Polychlorinated Biphenyls (Pcbs) Utilizing The Suzuki-Coupling, A Palladium-Catalyzed Cross-Coupling Reaction, Is Described. The Coupling Of (Chlorinated) Benzene Boronic Acids With Bromochlorobenzenes, Using Pd(Dppf)(2)Cl(2) (Dppf = 1,1'-Bis(Diphenylphosphino)Ferrocene) As The Catalyst And Aqueous Sodium Carbonate As The Base, Gave The Desired Pcb Congeners
合成参考文献
摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
📝 需求与反馈
尽可能描述清楚需求与问题信息
