CAS: 53-18-9; Bietaserpine

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      专利号:US-10925977-B2
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
      发明人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
      权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
      摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

      专利号:US-10814013-B2
      优先权日:2006-10-05
      标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:US-2008107598-A1
      优先权日:2006-10-05
      标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

      专利号:EP-2079486-A2
      优先权日:2006-10-05
      标题:Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:US-2013039853-A1
      优先权日:2006-10-05
      标题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

      专利号:CN-101678118-A
      优先权日:2006-10-05
      标 题:Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

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      主要参考文献


      1: Lehnert S. Factors influencing the toxicity of diethylaminoethylreserpine to tumor cells: studies with four transplantable tumors. Oncology. 1987;44(6):386-91.
      5: Lehnert S. Toxicity of diethylaminoreserpine to a transplantable tumor: the significance of the presence of hypoxic cells. Cancer Res. 1982 Aug;42(8):3028-32.
      7: Lehnert S. Toxicity of diethylaminoreserpine to tumor cells: effects of drug alone and in combination with radiation. Int J Radiat Oncol Biol Phys. 1982 Mar-Apr;8(3-4):505-9. French. Japanese. French. French. French. Japanese. French.

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      摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
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