CAS: 498-40-8; (R)-2-Amino-3-Sulfopropanoic Acid

该化合物是一种自然产生的氨酸衍生物,其特点是与细胞骨脊相连的全氟辛烷磺酸组(-SO3H)的存在.这是一种非蛋白性氨基酸,意谓在翻译过程中没有将其纳入蛋白质.L-cysteic酸通常以白晶状固体的形式出现,由于其极分功能组而溶于水中.其分子式为C3H7NO4S,其分子重量反映其碳,氢,氮,氧和硫的成分.该化合物在各种生物化学过程中发挥作用,包括含硫氨基酸的代谢作用.L-cysteic酸也可以作为其他生物相关分子合成的前体.在安全方面,如同许多氨基酸及其衍生物一样,在实验室环境中应谨慎处理,因为它在与皮肤或粘膜接触时可能造成刺激.

结构式图片

上下游产品

CAS号56-89-3 L-胱氨酸 | CAS号220951-71-3 2(S)-2-[(benzyl... | CAS号52-90-4 L-半胱氨酸 | CAS号143-33-9 氰化钠 | CAS号1010433-25-6 Grassypeptolide A | CAS号7647-01-0 盐酸 | CAS号7553-56-2 碘 | CAS号1115-65-7 L-半胱氨酸亚磺酸 | CAS号56-86-0 L-谷氨酸 | CAS号98022-26-5 3-sulfopyruvic acid | CAS号107-35-7 牛磺酸 | CAS号13100-82-8 磺基丙氨酸

合成工艺路线路线简述

    📜L-胱氨酸置于溴体系中,化学反应生成 L-磺基丙氨酸
    参考文献:The Crystal Structure Ofl-Cysteic Acid
    标题:The Crystal Structure Ofl-Cysteic Acid
    摘要:半胱氨酸 C3H7No5S 的晶体结构已经确定.该晶体为正菱形,空间群为 P212121,四个分子位于一个单位晶胞中,其尺寸分别为:A=8.35,B=10.16 和 C=7.44 å.该分子为齐聚离子-O3Sch2Ch-(Nh3+)Cooh;其尺寸与其他氨基酸和磺酸的尺寸基本相似.酸性基团占据 Cα-Cβ 键的反式位置,而氨基则处于磺酸基团的顺式位置,并在它们之间形成分子内氢键.
    DOI:10.1246/bcsj.41.2305

    海关参考信息

    专利信息


    专利号:US-11873305-B2
    优先权日:2020-06-30
    标题 :Processes for synthesis of substituted indole intermediates for the synthesis of serd compounds
    发明人:ZHANG HAIMING; XU JIE; WUITSCHIK GEORG; ANGELAUD REMY; HEROLD SEBASTIAN; STUTZ ALFRED; BRUETSCH TOBIAS; BURKHARD JOHANNES
    权利人:GENENTECH INC; HOFFMANN LA ROCHE
    摘要:Provided herein are processes for the preparation of indolyl intermediates using Wenker Synthesis for the total synthesis of SERD compounds useful in the treatment of cancer.

    专利号:WO-9312076-A1
    优先权日:1991-12-13
    标题:Reagents for automated synthesis of peptide analogs
    发明人:WEBB THOMAS ROY
    权利人:CORVAS INT INC
    摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

    专利号:US-5283293-A
    优先权日:1990-12-14
    标 题:Reagents for automated synthesis of peptide analogs
    发明人:WEBB THOMAS R
    权利人:CORVAS INC
    摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

    专利号:US-5367072-A
    优先权日:1990-12-14
    标 题 :Reagents for automated synthesis of peptide analogs
    发明人:WEBB THOMAS R
    权利人:CORVAS INT INC
    摘要:Reagents suitable for synthesis of peptide analogs using automated peptide synthesis and procedures for synthesis of peptide analogs are provided.

    专利号:US-12351573-B2
    优先权日:2019-05-09
    标 题:Compounds for use in synthesis of peptidomimetics
    发明人:AL-ABED YOUSEF; CHENG KAI FAN
    权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

    专利号:US-2023159450-A1
    优先权日:2020-05-08
    标 题 :Dimers for use in synthesis of peptidomimetics
    发明人:AL-ABED YOUSEF; ALTITI AHMAD
    权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
    摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: He Z, Sun R, Tang Z, Bu T, Wu Q, Li C, Chen H. Biodegradation of Feather Waste Keratin by the Keratin-Degrading Strain Bacillus subtilis 8. J Microbiol Biotechnol. 2018 Feb 28;28(2):314-322. doi: 10.4014/jmb.1708.08077. doi: 10.1021/acschembio.7b00314. Epub 2017 May 19. doi: 10.1039/c6fo01553k. doi: 10.1007/s00792-016-0860-8. Epub 2016 Jul 20. doi: 10.1080/00498254.2016.1196509. Epub 2016 Jun 27. doi: 10.1016/j.bioelechem.2012.08.008. Epub 2012 Sep 12. doi: 10.1107/S160053681202394X. Epub 2012 May 31.
    8: Liu FH. Poly[[μ(7)-l-cysteato(2-)]disodium]. Acta Crystallogr Sect E Struct Rep Online. 2011 Oct 1;67(Pt 10):m1346-7. doi: 10.1107/S1600536811035525. Epub 2011 Sep 14.
    9: Sasahara A, Nanatani K, Enomoto M, Kuwahara S, Abe K. Substrate specificity of the aspartate:alanine antiporter (AspT) of Tetragenococcus halophilus in reconstituted liposomes. J Biol Chem. 2011 Aug 19;286(33):29044-52. doi: 10.1074/jbc.M111.260224. Epub 2011 Jun 30.

    合成参考文献


    参考文献:10.1007/s00216-010-3471-8
    摘要:Roeser J, Bischoff R, Bruins AP, Permentier HP. Oxidative protein labeling in mass-spectrometry-based proteomics. Analytical and Bioanalytical Chemistry. 2010 Feb 13;397(8):3441–55. doi: 10.1007/s00216-010-3471-8.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知