CAS: 42588-57-8; 3-Ethoxymethacrolein

上下游产品

1,1,3,3-tetraethoxy-2-methyl-propane 1-chloro-3,3-diethoxy-2-methyl-propene 1,1-diethoxypropane N,N-dimethyl-formamide 5-(2-Formylpropenylamino)-3-methylisoxazol 2-methyl-3-(3-phenyl-isoxazol-5-ylamino)-propenal b]pyridine5-methyl-3-phenyl-isoxazolo[5,4-b]pyridine 3-amino-2-methyl acrolein

📜1,1,3,3-四乙氧基-2-甲基丙烷置于对甲苯磺酸体系中,用 水 作为反应溶剂,以92 %的收率获得产物2-甲基-3-乙氧基丙烯醛
参考文献:Optimization Of The Reaction Conditions For The Synthesis Of 2,3,5-Trimethylpyridine From 3-Amino-2-Methylpropenal And Methylethylketone
标题:Optimization Of The Reaction Conditions For The Synthesis Of 2,3,5-Trimethylpyridine From 3-Amino-2-Methylpropenal And Methylethylketone
摘要:研究了温度,反应时间和催化剂类型对以 3-氨基-2-甲基丙烯醛和甲基乙基酮为原料合成 2,3,5-三甲基吡啶(考来丁)的产率的影响.3-氨基-2-甲基丙烯醛是由 3-乙氧基-2-甲基丙烯醛合成的,而之前的甲基丙二醛四乙缩醛是由原甲酸三乙酯和丙烯基醚合成的.研究合成的最佳条件是温度为 150 摄氏度,反应时间为 24 小时,催化剂为 Ch3Cooh/ptsoh.该合成是在酸性介质中合成 2,3,5-三甲基吡啶的首次成功尝试.
DOI:10.2298/jsc210918042U

专利信息

专利号:US-5471005-A
优先权日:1994-11-18
标题 :Method of making 2,7-dimethyl-2,4,6-octatrienedial, a key intermediate in the commercial syntheses of various carotenoids
发明人：BABLER JAMES H
权利人:UNIV LOYOLA CHICAGO
摘要:A procedure for forming methylmalonaldehyde from propionaldehyde, an alkyl formate and a sodium alkoxide, utilizing a crossed-Claisen condensation is disclosed. The procedure avoids the formation of aldol condensation products. Also disclosed are processes for preparing 3-alkoxy-2-methylpropenals such as 2-methyl-3-(2-methyl-2-propenoxy)propenal from methylmalonaldehyde. The latter products are useful in the synthesis of carotenoids.

专利号:US-9187394-B2
优先权日:2011-12-26
标题:Method for synthesizing 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde
发明人：LV CHUNLEI; PI SHIQING; CHEN JIANHUI; LU DINGQIANG; OUYANG PINGKAI
权利人:NANJING UNIVERSITY OF TECHNOLOGY; ZHEJIANG MED XINCHANG PHARM
摘要:Provided in the present invention is a method for synthesizing 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde. The synthesis method comprises the following steps: (1) adding acetaldehyde diethyl acetal and ethyl-(1-propenyl)-ether under the effect of a catalyst to produce 1,1,3-triethoxy-2-methyl-butane; (2) pyrolysis synthesizing 1,1,3-triethoxy-2-methyl-butane under the catalytic effects of isoquinoline and p-Toluenesulfonic acid to produce 1-methoxy-2-methyl-1,3-butadiene; (3) dissolving 1-methoxy-2-methyl-1,3-butadiene in anhydrous ethanol solvent for synthesis with a phase transfer catalyst, cetyl-trimethyl ammonium bromide, and a chlorinating agent, trichloroisocyanuric acid, to generate 4,4-diethoxy-3-methyl-1-chloro-butene; (4) combining 4,4-diethoxy-3-methyl-1-chloro-butene with a triphenylphosphine salt to produce a phosphonium salt; and (5) condensing the phosphonium salt under the effects of hydrogen peroxide in conjunction with sodium carbonate solution to generate 1,1,8,8-tetramethyl-2,7-dimethyl-2,4,6-octatriene; then hydrolyzing under acidic conditions to synthesize 2,7-dimethyl-2,4,6-octatriene-1,8-dialdehyde. The present invention has a simple process route, is easy to operate, and has mild conditions, great yield, and great industrial value.