CAS: 41621-49-2; 6-Cyclohexyl-1-Hydroxy-4-Methylpyridin-2(1H)-One 2-Aminoethanol Salt

相似化合物

67587-24-0 1138218-09-3 769114-73-0

上下游产品

CICLOPIROX ethanolamine 3-Methylbutenoic acid Cyclohexanecarboxylic acidCICLOPIROX

环己甲酸置于吡啶,Aluminum (Iii) Chloride,氯化亚砜体系中,用 二氯甲烷,乙酸乙酯 作为反应溶剂,化学反应 27.5H,反应生成 环吡司胺
参考文献:一种环吡酮胺的合成方法
标题:一种环吡酮胺的合成方法
摘要:本发明公开了一种环吡酮胺的合成方法,包括如下步骤:(1)制备二甲基丙烯酸甲酯;(2)制备环己烷甲酰氯;(3)制备5‑氧代‑3‑甲基‑5‑环己基‑3‑戊烯酸甲酯;(4)制备1‑羟基‑4‑甲基‑6‑环己基‑2(1H)‑吡啶酮;(5)制备1‑羟基‑4‑甲基‑6‑环己基‑2(1H)‑吡啶酮‑2‑氨基乙醇盐环吡酮胺;有益效果:本发明产率高,产品质量高,运行成本低,设备可自动运行,稳定性好,容易实现工业化需求.

专利信息

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

专利号:US-10933051-B2
优先权日:2017-06-09
标 题 :Carbapenem compounds and compositions for the treatment of bacterial infections
发明人：CHOI WOO-BAEG; TOMIOKA TAKASHI; JOO HYUNG-YEUL; TRUONG PHONG; MIN BRIAN
权利人:FOB SYNTHESIS INC
摘要:The present invention provides carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections, including drug resistant or multiple-drug resistant bacterial infections, and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

专利号:US-2012095058-A1
优先权日:2003-12-03
标 题 :Method of preventing survival of retrovirally cells and of inhibiting formation of infectious retroviruses
发明人：HANAUSKE-ABEL H M; PALUMBO PAUL; CRACCHIOLO B M; PARK MYUNG-HEE; WOLFF EDITH; HANAUSKE AXEL-RAINER; MATHEWS MICHAEL B; SAXENA DEEPTI; HOQUE MAINUL
权利人:HANAUSKE-ABEL H M; PALUMBO PAUL; CRACCHIOLO B M; PARK MYUNG-HEE; WOLFF EDITH; HANAUSKE AXEL-RAINER; MATHEWS MICHAEL B; SAXENA DEEPTI; HOQUE MAINUL
摘要:The present invention discloses compounds and pharmaceutical compositions which are highly effective at inhibiting the accumulation of spliced and unspliced viral transcripts and their utilization for viral protein synthesis at cellular ribosomes, and at inhibiting the formation of the hypusine residue in cellular eIF-5A precursor proteins, the cellular cofactors that render spliced and unspliced viral transcripts translatable at the ribosomes of infectled cells. The invention further relates to methods of using such compounds and pharmaceutical compositions therefrom for inhibiting or preventing viral protein synthesis. Such inhibition cause a dose-dependent release from the virally induced arrest of the otherwise genetically preprogrammed apoptosis of virally infected cells, and in consequence, triggers their apoptotic ablation and the eradication of the chronic infection-mediating provirus integrated into their genome.

专利号:US-2007203079-A1
优先权日:2005-11-21
标题:Methods of using small molecule compounds for neuroprotection
发明人：CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG
权利人:CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG
摘要:Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.

专利号:US-9937151-B2
优先权日:2010-06-18
标题 :Carbapenem antibacterials with gram-negative activity
发明人：CHOI WOO-BAEG; GRUSZECKA-KOWALIK EWA; JOO HYUNG-YEUL; LIU SHUANGPEI; MAO SHULI; LI YONGFENG; KIM DEOG-IL
权利人:FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment.

专利号:WO-2009056955-A1
优先权日:2007-10-30
标题 :Amine-bearing phospholipids (abps), their synthesis and use
发明人：ZUMBUEHL ANDREAS
权利人:UNIV BASEL; ZUMBUEHL ANDREAS
摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.