CAS: 4001-73-4; 2-Bromobenzamide

该化合物是一种溴化芳香胺化合物,通常用作有机合成和制药制造的中间体,其主要优点包括纯度和稳定性高,适合铃木结合,Buchwald-Hartwig配方和其他催化变异等精确反应.在正方位的溴代二苯基可增强交叉反应的再活动性,而氨基组则提供多功能性,以进一步实现功能化.该化合物对于发展农用化学,染料和活性制药成分(API)特别有用.建议,由于对湿度和光度的敏感性,在受管制条件下进行适当处理.

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ECHA物质C&L通报REACH预注册

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CAS号2042-37-7 邻溴苯腈 | CAS号34158-72-0 2-溴苯甲醛肟 | CAS号610-94-6 2-溴苯甲酸甲酯 | CAS号6630-33-7 2-溴苯甲醛 | CAS号108-86-1 溴苯 | CAS号2039-88-5 2-溴苯乙烯 | CAS号36081-66-0 1-(2-溴苯基)-2-苯基-1-乙酮 | CAS号7154-66-7 2-溴苯甲酰氯 | CAS号88-65-3 邻溴苯甲酸 | CAS号491-36-1 4-Quinazolinone | CAS号491-30-5 异喹诺酮 | CAS号2042-37-7 邻溴苯腈 | CAS号73096-42-1 5-(2-溴苯基)-1H-四唑 | CAS号6832-87-7 2-溴-N-甲基苯胺 | CAS号49851-55-0 2-溴苯酰甲基溴 | CAS号3137-64-2 4-羟基-2-乙基喹唑啉 | CAS号36081-66-0 1-(2-溴苯基)-2-苯基-1-乙酮 | CAS号1022-45-3 2-苯基-4-[3H]喹唑啉酮

合成工艺路线路线简述

    📜2-溴苯甲酸置于ammonium Hydroxide,氯化亚砜体系中,用 二氯甲烷 作为反应溶剂,化学反应 1.0H,反应生成 2-溴苯甲酰胺
    参考文献:Rh(iii)催化的重氮化合物与重氮化合物对苯甲酰胺的中性环氧化:异喹啉酮的方法
    标题:Rh(iii)催化的重氮化合物与重氮化合物对苯甲酰胺的中性环氧化:异喹啉酮的方法
    摘要:本文报道的是初级苯甲酰胺与重氮化合物的rh催化氧化还原中性环化反应,代表了对异喹啉酮的有效和经济方案.该过程表现出非常好的官能团耐受性,可伸缩性,和区域选择性,避免了对氧化剂的需要,并且只对环境无害ñ 2和h 2 ö被释放.该方法的进一步利用为功能化的异喹啉提供了另一种途径.
    DOI:10.1021/acs.Joc.5B02824

    海关参考信息

    专利信息


    专利号:US-9174943-B2
    优先权日:2010-02-24
    标 题 :Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds
    发明人:JAIN RAJENDRA PARASMAL; ANGELAUD REMY; THOMPSON ANDREW; LAMBERSON CAROL; GREENFIELD SCOTT
    权利人:JAIN RAJENDRA PARASMAL; ANGELAUD REMY; THOMPSON ANDREW; LAMBERSON CAROL; GREENFIELD SCOTT; MEDIVATION PROSTATE THERAPEUTICS INC
    摘要:Processes are provided for the synthesis of diarylthiohydantoin and diarylhydantoin compounds. Medicinal products containing the same find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.

    专利号:US-2024174698-A1
    优先权日:2022-09-23
    标题 :Modular synthesis of 1,2-azaborines via ring-opening bn-isostere benzannulation
    发明人:DONG GUANGBIN; LYU HAIRONG; CHEN ZHIJIE; WU YIFEI; CHOI SHINYOUNG
    权利人:UNIV CHICAGO
    摘要:The present disclosure relates generally to 1,2-azaborines and methods of making the same.

    专利号:US-8304550-B2
    优先权日:2007-11-30
    标题 :Process for the catalytic synthesis of diaryl ethers
    发明人:COTTE ALAIN; MULLER NIKOLAUS; GOTTA MATTHIAS; BELLER MATTHIAS; SCHAREINA THOMAS; ZAPF ALEXANDER
    权利人:COTTE ALAIN; MULLER NIKOLAUS; GOTTA MATTHIAS; BELLER MATTHIAS; SCHAREINA THOMAS; ZAPF ALEXANDER; SALTIGO GMBH
    摘要:Described is a process for preparing diaryl ethers of the formula (I)n nAr—O—Ar′  (I)n n In which Ar is an aryl or substituted aryl group and Ar′ is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group, n by reacting an aryl of formula (II) or a aryloxy salt of formula (III)n nAr—OH  (II)n nAr—OR  (III)n n In which Ar has the same meaning as in formula (I) and R is an alkali metal, n with an aryl or heteroaryl bromide of formula (IV)n nAr′—Br  (IV)n n In which Ar′ has the same meaning as in formula (I), n characterized in that the reaction is carried out in the presence of a copper(I)salt and a 1-substituted imidazole as catalyst system.

    专利号:KR-101514659-B1
    优先权日:2010-02-24
    标 题 :Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds

    专利号:ES-2671343-T3
    优先权日:2010-02-24
    标 题 :Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds

    专利号:JP-2013520519-A
    优先权日:2010-02-24
    标题:Process for the synthesis of diarylthiohydantoin compounds and diarylhydantoin compounds

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Monica Carreira, Et Al. Organometallic Palladium Complexes With A Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents. Organometallics. 2012 Aug 27;31(16):5772-5781.

    合成参考文献


    摘要:Harris, P. A., Science of Synthesis Knowledge Updates, (2021) 3, 99.
    摘要:Khartulyari, A.; Maier, M. E., Science of Synthesis Knowledge Updates, (2010) 3, 80.
    摘要:Glushkov, V. A.; Shklyaev, Yu. V., Science of Synthesis Knowledge Updates, (2018) 3, 247.
    摘要:Kang, F.-A.; Yang, S.-M., Science of Synthesis Knowledge Updates, (2015) 2, 201.
    摘要:Campagne, J. M.; Leclerc, E., Science of Synthesis Knowledge Updates, (2020) 2, 186.
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