专利号:US-9174943-B2 优先权日:2010-02-24 标 题 :Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds 发明人:JAIN RAJENDRA PARASMAL; ANGELAUD REMY; THOMPSON ANDREW; LAMBERSON CAROL; GREENFIELD SCOTT 权利人:JAIN RAJENDRA PARASMAL; ANGELAUD REMY; THOMPSON ANDREW; LAMBERSON CAROL; GREENFIELD SCOTT; MEDIVATION PROSTATE THERAPEUTICS INC 摘要:Processes are provided for the synthesis of diarylthiohydantoin and diarylhydantoin compounds. Medicinal products containing the same find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.
专利号:US-2024174698-A1 优先权日:2022-09-23 标题 :Modular synthesis of 1,2-azaborines via ring-opening bn-isostere benzannulation 发明人:DONG GUANGBIN; LYU HAIRONG; CHEN ZHIJIE; WU YIFEI; CHOI SHINYOUNG 权利人:UNIV CHICAGO 摘要:The present disclosure relates generally to 1,2-azaborines and methods of making the same.
专利号:US-8304550-B2 优先权日:2007-11-30 标题 :Process for the catalytic synthesis of diaryl ethers 发明人:COTTE ALAIN; MULLER NIKOLAUS; GOTTA MATTHIAS; BELLER MATTHIAS; SCHAREINA THOMAS; ZAPF ALEXANDER 权利人:COTTE ALAIN; MULLER NIKOLAUS; GOTTA MATTHIAS; BELLER MATTHIAS; SCHAREINA THOMAS; ZAPF ALEXANDER; SALTIGO GMBH 摘要:Described is a process for preparing diaryl ethers of the formula (I)n nAr—O—Ar′  (I)n n In which Ar is an aryl or substituted aryl group and Ar′ is an aryl, substituted aryl, heteroaryl or substituted heteroaryl group, n by reacting an aryl of formula (II) or a aryloxy salt of formula (III)n nAr—OH  (II)n nAr—OR  (III)n n In which Ar has the same meaning as in formula (I) and R is an alkali metal, n with an aryl or heteroaryl bromide of formula (IV)n nAr′—Br  (IV)n n In which Ar′ has the same meaning as in formula (I), n characterized in that the reaction is carried out in the presence of a copper(I)salt and a 1-substituted imidazole as catalyst system.
专利号:KR-101514659-B1 优先权日:2010-02-24 标 题 :Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds
专利号:ES-2671343-T3 优先权日:2010-02-24 标 题 :Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds
专利号:JP-2013520519-A 优先权日:2010-02-24 标题:Process for the synthesis of diarylthiohydantoin compounds and diarylhydantoin compounds
[参考文献]: Monica Carreira, Et Al. Organometallic Palladium Complexes With A Water-Soluble Iminophosphorane Ligand As Potential Anticancer Agents. Organometallics. 2012 Aug 27;31(16):5772-5781.
合成参考文献
摘要:Harris, P. A., Science of Synthesis Knowledge Updates, (2021) 3, 99. 摘要:Khartulyari, A.; Maier, M. E., Science of Synthesis Knowledge Updates, (2010) 3, 80. 摘要:Glushkov, V. A.; Shklyaev, Yu. V., Science of Synthesis Knowledge Updates, (2018) 3, 247. 摘要:Kang, F.-A.; Yang, S.-M., Science of Synthesis Knowledge Updates, (2015) 2, 201. 摘要:Campagne, J. M.; Leclerc, E., Science of Synthesis Knowledge Updates, (2020) 2, 186.