CAS: 3878-55-5; 4-Methoxy-4-Oxobutanoic Acid

相似化合物

106-65-0 1070-34-4 123-25-1

上下游产品

CAS号106-65-0 琥珀酸二甲酯 | CAS号13013-02-0 甲基-4-硝基丁酸 | CAS号67-56-1 甲醇 | CAS号110-15-6 琥珀酸； 丁二酸 | CAS号108-30-5 丁二酸酐 | CAS号14734-25-9 甲基琥珀酸叔丁酯 | CAS号6654-36-0 6-氧代己酸甲酯 | CAS号108-31-6 顺酐 | CAS号110-17-8 富马酸,反丁烯二酸 | CAS号110-88-3 三聚甲醛 | CAS号3395-91-3 3-溴丙酸甲酯 | CAS号506-17-2 十八烷酸 | CAS号41826-92-0 曲匹布通 | CAS号505-48-6 辛二酸 | CAS号627-93-0 己二酸二甲酯 | CAS号20291-40-1 7-甲氧基-7-氧代庚酸 | CAS号2177-82-4 methyl 4-methyl... | CAS号554-12-1 丙酸甲酯 | CAS号50674-05-0 | CAS号344295-00-7 methyl heptanoa...

Methyl 4-Oxo-5-Chloro-5,5-Dinitrovalerate置于air体系中,化学反应 192.0H,以77%的收率获得产物丁二酸单甲酯
参考文献:Stepanova,O. P.; Poryadkova,M. A.; Golod,E. L.,Russian Journal Of Organic Chemistry,1994,Vol. 30,# 10.1,P. 1533-1537
标题:Stepanova,O. P.; Poryadkova,M. A.; Golod,E. L.,Russian Journal Of Organic Chemistry,1994,Vol. 30,# 10.1,P. 1533-1537

专利信息

专利号:US-11717498-B2
优先权日:2013-12-31
标题 :Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms
发明人：POPP KARL; MECKLER HAROLD
权利人:Chemapotheca LLC; PHARMAPOTHECA A INC
摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

专利号:US-9802952-B2
优先权日:2013-07-15
标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
发明人：KOPETZKI DANIEL; MCQUADE DAVID TYLER; SEEBERGER PETER H; GILMORE KERRY
权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V; MAX-PLANK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V
摘要:The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C 1 -C 5 alcohol.

专利号:WO-2013121018-A1
优先权日:2012-02-17
标题 :Synthesis of cyanocarboxylic acid alkyl esters
发明人：FRANZKE CONSTANZE; OTT LOTHAR; GRUETZNER THOMAS; LITZMANN OLIVER; REPKE JENS-UWE; HAMMANN MARKUS; LORENZ HILKE-MARIE; MEEMKEN FABIAN CARL INGOLD
权利人:LONZA AG
摘要:Provided is a process for obtaining a compound of formula (I): N≡C-CH 2 -A-C(O)-OR, wherein Hal is halogen selected from F, Cl, Br or I, A denotes a bond or a divalent spacer selected from alkylene and arylene groups, and R is a C 1-4 alkyl group, by reacting a compound of formula (II): Hal-CH 2 -A-C(O)-OR, wherein Hal is a halogen atom selected from F, Cl, Br and I, and wherein A and R are as defined above, with hydrogen cyanide in the presence of a first base, wherein the molar ratio between hydrogen cyanide and said first base is from 1:0.3 to 1:0.95 and the molar ratio between hydrogen cyanide to the compound of formula (II) is at least 1:1.

专利号:US-6444460-B1
优先权日:1998-08-19
标 题:Microbial production of actinol
发明人：SHIMIZU SAKAYU; WADA MASARU
权利人:ROCHE VITAMINS INC
摘要:A process for making (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone by contacting (6R)-2,2,6-trimethylcyclohexanedione with a microorganism which is selected from microorganisms of the genera Cellulomonas, Corynebacterium, Planococcus and Arthrobacter and which is capable of the selective asymmetric reduction of (6R)-2,2,6-trimethylcyclohexanedione to (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone, and recovering the resulting (4R, 6R)-4-hydroxy-2,2,6-trimethylcyclohexanone from the reaction mixture. The selective asymmetric reduction can be effected in the presence of a co-factor, such as, nicotinamide adenine dinucleotide (NAD), nicotinamide adenine dinucleotide phosphate (NADP), or said co-factor with glucose and glucose dehydrogenase (GDH), and/or in the presence of a surfactant. The product is useful for the synthesis of carotenoids, such as, zeaxanthin.

专利号:US-6281245-B1
优先权日:1996-10-28
标 题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
发明人：PATEL DINESH V; NGU KHEHYONG
权利人:VERSICOR INC
摘要:A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteinases).

专利号:US-8344168-B2
优先权日:2006-06-14
标题 :Process for the preparation of fluticasone propionate
发明人：GORE VINAYAK G; GADAKAR MAHESH; POKHARKAR K; WAKCHURE V
权利人:GENERICS UK LTD; GORE VINAYAK G; GADAKAR MAHESH; POKHARKAR K; WAKCHURE V
摘要:The present invention relates to a process for the preparation of steroidal 17β-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17β-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.