CAS: 38749-90-5; 5-Bromo-2-Ethylpyridine

相似化合物

312325-72-7 1159820-58-2 38749-81-4

上下游产品

2-Ethylpyridine 2-ethynyl-5-bromo-pyridine 3-bromo-6-(trimethylsilylethynyl)pyridine 5-bromo-2-chloropyridine2-ethyl-5-benzyloxypyridine 2-Ethyl-5-vinyl-pyridin 1-[1-(5-cyanopyridin-2-yl)ethyl]-2-methyl-4-oxo-2′-trifluoromethyl-1,4-dihydro[3,4′]bipyridinyl-5-carboxylic acid methylamide 1-[1-(5-bromopyridin-2-yl)ethyl]-2-methyl-4-oxo-2′-trifluoromethyl-1,4-dihydro[3,4′]bipyridinyl-5-carboxylic acid methylamide

📜5-溴-2-乙炔吡啶置于platinum(Iv) Oxide 氢气体系中,用 乙醇 用作溶剂,化学反应生成2-乙基-5-溴吡啶
参考文献:Urea Inhibitors Of Map Kinases
标题:Urea Inhibitors Of Map Kinases
摘要:本文描述了含有抑制map激酶的尿素类化合物,包括这些化合物的药物组合物以及使用这些化合物治疗炎症性疾病和癌症的方法.

专利信息

专利号:US-8329905-B2
优先权日:2006-06-30
标 题 :Synthesis of diethyl{[5-(3-fluorophenyl)-pyridine-2yl]methyl}phosphonate
发明人：YONG KELVIN H; ZAVIALOV ILIA A; YIN JIANGUO; FU XIAOYONG; THIRUVENGADAM THIRUVETTIPURAM K
权利人:YONG KELVIN H; ZAVIALOV ILIA A; YIN JIANGUO; FU XIAOYONG; THIRUVENGADAM THIRUVETTIPURAM K; MERCK SHARP & DOHME
摘要:This application discloses a novel process for the preparation of phosphonate esters useful as intermediates in the preparation of himbacine analogs, themselves useful as thrombin receptor antagonists. The chemistry taught herein can be exemplified by the following scheme: n nwherein R 9 is selected from alkyl, aryl heteroaryl and arylalkyl groups having 1 to 10 carbon atoms, and R 11 is selected independently for each occurrence from alkyl, aryl heteroaryl and arylalkyl groups having 1 to 10 carbon atoms and hydrogen, X 2 is Cl, Br, or I; X 3 is selected from Cl and Br; and PdL n is a supported palladium metal catalyst or a soluble heterogeneous palladium catalyst. The L-derivatizing reagent is a moiety which converts the alcohol functional group of compound 137D to any leaving group which can be displaced by a triorgano-phosphite phosphonating agent.

专利号:US-2008004449-A1
优先权日:2006-06-30
标题:Synthesis of diethyl{[5-(3-fluorophenyl)-pyridine-2yl]methyl}phosphonate

专利号:US-8258319-B2
优先权日:2005-01-14
标 题:Exo- and diastereo- selective synthesis of himbacine analogs

专利号:US-2011251392-A1
优先权日:2005-01-14
标 题:Exo- and diastereo- selective synthesis of himbacine analogs

专利号:US-7687631-B2
优先权日:2006-06-30
标 题 :Synthesis of diethyl{[5-(3-fluorophenyl)-pyridine-2yl]methyl}phosphonate

专利号:US-2012296093-A1
优先权日:2005-01-14
标题 :Exo- and diastereo- selective synthesis of himbacine analogs