专利号:WO-9824022-A1 优先权日:1996-11-22 标题:Method for incremental synthesis of a discrete technical system 发明人:STEFFEN BERNHARD 权利人:METAFRAME TECHNOLOGIES SOFTWAR; STEFFEN BERNHARD 摘要:Disclosed is a method for knowledge-based incremental synthesis of a discrete technical system dependent upon a predetermined first configuration, wherein the first configuration represents an implemented consistent conflict-free causal structure. The first configuration comprises a predetermined knowledge base and a description of requirements controlling the synthesis, wherein a second configuration which fulfills the description of requirements is generated in the following steps: synthesis of a completed first intermediate causal structure that is not necessarily consistent or conflict-free, arising from the first configuration and the description of requirements by means of a fusion specification, and transformation of the first intermediate causal structure into a not necessarily conflict-free completed consistent second intermediate causal structure, and transformation of the completed second intermediate causal structure into a conflict-free consistent causal structure corresponding to the second configuration of the technical system by conflict resolution using conflict resolution conditions.
专利号:EP-2260936-B1 优先权日:2004-11-25 标题:Method for specifically located synthesis of nucleic acids on solid carriers 发明人:ELLINGER THOMAS; ERMANTRAUT EUGEN; HOLZHEY NANCY; PLENZ FRANK; SCHULZ TORSTEN; TUCHSCHEERER JENS; WEICHERDING DANIEL 权利人:CLONDIAG GMBH 摘要:Type-specific synthesis of bio-polymers of a defined sequence on pre-determined ranges of a solid carrier comprises gradual coupling of monomer and/or oligomer components (I); where, before the coupling step, at least a pre-determined area of the carrier are activated for coupling of (I) to activate the reactive groups; and the temporary group for protection are removed by addition of an activation reagent in aqueous solution, is new. Independent claims are also included for: (1) a procedure for the type-specific synthesis of biopolymers of a defined sequence on pre-determined ranges of solid carrier, comprising: (a) arranging a mask on the carrier (for coupling of (I) of the biopolymer, which is to be synthesized for controlling available reactive groups with protection groups to the carrier); (b) activating the reactive groups by removing the temporary protective groups at the ranges given by the mask, by adding the activation reagent in aqueous solution; (c) coupling (I) with activated reactive groups; and (d) repeating step (a) to (c), until the desired biopolymers is synthesized; (2) a micro array prepared by the process; and (3) a micro array with pre-determined ranges immobilized biopolymer probes, where the proportional portion P at biopolymers, which exhibits the desired number of monomer M, is given by the formula P = S-M (where S is an average step yield with the coupling of (I); and the density at pre-determined ranges is at least 1500 spots per cm 2>and the average step yield is 95 (preferably 98) %).
专利号:EP-1546732-B1 优先权日:2002-09-03 标 题:Modulation of the synthesis of insulin 发明人:WALTHER REINHARD 权利人:UNIV ERNST MORITZ ARNDT 摘要:The invention particularly relates to the use of substances, which modulate the activity of the proteins casein kinase II (CK II) and 14-3-3 epsilon and/or of the PcG protein EED or which influence the binding of the proteins casein kinase II (CK II) and 14-3-3 epsilon, of the PcG protein EED and/or of a fragment thereof with the protein pancreatic duodenal homeobox-1 (PDX-1) that plays a decisive roll in the glucose-induced biosynthesis of insulin, for influencing the synthesis of insulin or the provision of insulin.
专利号:US-10040752-B2 优先权日:2015-08-24 标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof 发明人:MKRTCHYAN GNEL; YAO QINGWEI 权利人:CODY LABORATORIES INC 摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.
专利号:EP-1232226-B1 优先权日:2000-09-08 标题:Synthesis of nanoparticles 发明人:HAUBOLD STEPHAN; HAASE MARKUS; RIWOTZKY CARSTEN; WELLER HORST; MEYSAMMY HEIKE; IBARRA FERNANDO 权利人:NANOSOLUTIONS GMBH 摘要:Production of inorganic nanoparticles that can be fluoresced consisting of a host material containing a dopant comprises using an organic solvent for liquid phase synthesis of the particles.
专利号:WO-2019197122-A1 优先权日:2018-04-10 标 题:Process for treatment of at least one cell with a chemical synthesis product in a microarray 发明人:BENZ MAXIMILIAN; LEVKIN PAVEL A; MOLLA MIJANUR R; ROSENFELD ALISA; BREHM MARIUS 权利人:KARLSRUHER INST TECHNOLOGIE 摘要:The present invention relates to a process for treatment of at least one cell with a chemical synthesis product in a microarray, a stacked microarray, a kit comprising at least one microarray and the use of a microarray for the chemical synthesis of a chemical synthesis product and for the treatment of at least one cell with the chemical synthesis product in a microarray.
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合成参考文献
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