CAS: 33889-69-9; (2R,3R)-3,5,7-Trihydroxy-2-((2R,3S)-7-Hydroxy-2-(4-Hydroxy-3-Methoxyphenyl)-3-(Hydroxymethyl)-2,3-Dihydrobenzofuran-5-yl)Chroman-4-One

该化合物是主要来自奶瓶植物Silybum marianum的裂变质化合物,以其抗氧化特性和潜在的健康惠益而闻名,特别是在肝脏保护和脱毒方面.Slychristin展示了一个复杂的结构,其特征是多种氢氧基,有助于其保存自由基和调节各种生物化学途径的能力.该化合物经常因其在支持肝脏健康方面的作用而进行研究,因为它可能加强肝细胞的再生,并保护其免受肝中毒.此外,Silychristin因其抗炎和抗癌特性而受到调查,使其成为药理学研究的一个对象.其有机溶剂中的溶性以及水溶性有限是影响其生物利用和治疗应用的重要特征.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号1835-11-6 4-苄氧基-3-甲氧基苯乙酮 | CAS号124662-51-7 1-(4-benzyloxy-... | CAS号16414-34-9 6-溴-2_3-二羟基苯甲醛

合成工艺路线路线简述

  • 65666-07-1 = 33889-69-9 + 480-18-2 + 22888-70-6 + 142796-22-3 + 1220986-69-5 + 29782-68-1 + 1516881-20-1 + 1516881-22-3 + 142796-21-2 + 142797-34-0
    反应条件:1.1C:1435939-45-9,S:Me2Co,24 H,45°C
    标题:Preparative Method For Isosilybin Isolation Based On Enzymatic Kinetic Resolution Of Silymarin Mixture
    作者:By Gazak,Radek Et Al
    参考文献:Process Biochemistry (Oxford 日期:2013 卷标:48(1) 页码:184-189
📜[3-[(2R,3S)-7-(Methoxymethoxy)-2-[3-Methoxy-4-(Methoxymethoxy)Phenyl]-3-(Methoxymethoxymethyl)-2,3-Dihydro-1-Benzofuran-5-Yl]Oxiran-2-Yl]-[2,4,6-Tris(Methoxymethoxy)Phenyl]Methanone,盐酸 反应生成水飞蓟亭
参考文献:Tanaka,Histoshi;Hiroo,Masaru;Ichino,Kazuhiko;Ito,Kazuo,J. Chem. Soc. Chem. Commun.,(1988) N 11,749-751
标题:Tanaka,Histoshi;Hiroo,Masaru;Ichino,Kazuhiko;Ito,Kazuo,J. Chem. Soc. Chem. Commun.,(1988) N 11,749-751

海关参考信息

专利信息


专利号:US-7598291-B2
优先权日:2004-09-02
标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin
发明人:NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:US-2010160244-A1
优先权日:2004-09-02
标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin
发明人:NIMNI MARCEL; HAN BO
权利人:NIMNI MARCEL; HAN BO
摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.

专利号:WO-2006053688-A1
优先权日:2004-11-17
标 题:Cosmetic and dermatological preparations for the treatment of mature skin
发明人:DOERING THOMAS
权利人:HENKEL KGAA; DOERING THOMAS
摘要:The invention relates to topical cosmetic or dermatological compositions for the treatment of mature or intrinsically or extrinsically aged skin, in particular, for anti-wrinkle treatment, containing a combination of at least two selected peptides in a suitable cosmetic or dermatological vehicle, which have an effect at differing points of the process of collagen and/or fibronectin synthesis.

专利号:WO-2006042625-A2
优先权日:2004-10-15
标 题 :Compositions with inhibitors of the synthesis of prostaglandin and/or of leukotriene in conjunction with stimulators of the release of cutaneous neuromediators

专利号:EP-1799311-A2
优先权日:2004-10-15
标 题:Compositions with inhibitors of the synthesis of prostaglandin and/or of leukotriene in conjunction with stimulators of the release of cutaneous neuromediators

专利号:DE-102005000868-A1
优先权日:2004-10-15
标 题:Compositions with inhibitors of prostaglandin and / or leukotriene synthesis in combination with stimulants of the release of cutaneous neuromediators

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品牌试剂参考报价(招募中)

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✅ COA系统入驻 | 共享模式

主要参考文献


1: Greimel A, Koch H. Silymarin--ein Hemmstoff der Meerretichperoxidase [Silymarin--an inhibitor of horseradish peroxidase (author's transl)]. Experientia. 1977 Nov 15;33(11):1417-8. French. doi: 10.1007/BF01918777. 32(4):331-41. German. doi: 10.1055/s-0028-1097608. 33(12):1568-9. German. doi: 10.1007/BF01934001. 35(12):1548-60. doi: 10.1007/BF01953184. 35(12):1550-2. doi: 10.1007/BF01953185. 314(6):515-7. German. doi: 10.1002/ardp.19813140608. 7(8):409-13. 86 Suppl
2:79-85. doi: 10.1590/s0074-02761991000600020. 25(2):147-54. doi: 10.1016/1043-6618(92)91383-r. 113(3):275-7. Russian. 290(3):1375-83. 13(6):535-7. doi: 10.1002/(sici)1099-1573(199909)13:6<535::aid- ptr526>3.0.co;2-w. 7(1):21-4. doi: 10.1016/S0944-7113(00)80017-3. 71(4):379-84. doi: 10.1016/s0367-326x(00)00134-9. 67(9):876-7. doi: 10.1055/s-2001-18860. 15(7):608-12. doi: 10.1002/ptr.879. 16 Suppl
1:S63-7. doi: 10.1002/ptr.811. 16(6):510-2. Chinese. 30(3):613-24. doi: 10.1016/s0731-7085(02)00352-7. 16(7):632-8. doi: 10.1002/ptr.1000.

合成参考文献


参考文献:10.1038/s41592-019-0358-2]
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