CAS: 31121-93-4; Sodium 2-(4-Isobutylphenyl)Propanoate

该化合物是一种该化合物是一种广泛使用的非类固醇抗炎药物,即ibuprofen(NSAID),在水溶液中增强溶解性,可以比标准的ibuprofen配方更快地吸收和采取行动.这种特性使得它特别适合需要快速止痛和抗炎效果的应用,如注射或快速解析口服药.Ibuprofen钠保留了ibuprofen的药理学特征,包括环氧氧素抑制剂,同时在某些配方中提供更好的生物利用率.其化学稳定性和与前抗体的兼容性进一步支持其药物开发的效用.该化合物通常作为白色向非白的晶状粉供应,符合纯度和烈度的药理标准.

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欧盟法规

ECHA物质C&L通报REACH预注册

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CAS号15687-27-1 布洛芬 | CAS号51146-56-6 (S)-(+)-布洛芬 | CAS号36039-36-8 2-(4-异丁基苯基)丙-1-醇 | CAS号51146-56-6 (S)-(+)-布洛芬

合成工艺路线路线简述

    📜2-苯基丙酸,布洛芬,钠 反应生成布洛芬钠
    参考文献:Process Of Resolving Phenylpropionic Acids Using
    标题:Process Of Resolving Phenylpropionic Acids Using
    摘要:一种生产制备含有苯丙酸的手性异构体的产品的方法,所述苯丙酸选自布洛芬和氟布洛芬,或其药用盐,该方法包括分离阶段,再结晶阶段,可选的解放阶段和可选的盐制备阶段.将苯丙酸的基本混合物与α-甲基苯乙胺的手性异构体以特定比例接触,以制备手性富集的产品.

    海关参考信息

    专利信息


    专利号:US-4282252-A
    优先权日:1980-05-15
    标 题 :Method of increasing coronary blood flow with ibuprofen
    发明人:LEFER ALLAN M
    权利人:UNIV JEFFERSON
    摘要:Novel treatments are disclosed for increasing circulating coronary blood flow. These treatments are useful for individuals who are expected to otherwise exhibit symptoms of reduced coronary circulation. Such individuals include those having coronary artery disease, angina, particularly unstable angina and Prinzmetal's angina, and coronary vasospasm. In accordance with the disclosed methods, coronary vasodilation is accomplished through the administration of effective amounts of buiprofen and/or flurbiprofen. At the indicated dosages, thromboxane synthesis is effectively inhibited without inhibiting prostacyclin synthesis. Flurbiprofen administration additionally results in thromboxane antagonism.

    专利号:US-8540939-B2
    优先权日:2008-04-28
    标 题:Instrument and process for nanoparticles production in continuous flow mode
    发明人:NIESZ KRISZTIAN; WOOTSCH ATILLA; GROUALLE MAXIME; OETVOES ZSOLT; DARVAS FERENC
    权利人:NIESZ KRISZTIAN; WOOTSCH ATILLA; GROUALLE MAXIME; OETVOES ZSOLT; DARVAS FERENC; DARHOLDING VAGYONKEZELO KORLATOLT FELELOSSEGU TARSASAG
    摘要:A continuous flow system for the synthesis of nanoparticles includes a feeding unit connected to the first reactor a flow path, at least one first reactor unit possessing a heatable reactor-zone, a second reactor unit which follows the first reactor in the same cascade; a mixing unit and a second feeding unit between the reactor units, and feeding pumps connected to a raw material source and/or a control unit which is capable of controlling at least one pressure controller and/or controlling the temperature of at least one heatable reactor-zone; each heatable reactor-zone is followed by a cooling unit in the cascade. In addition, a process for the synthesis of nanoparticles, preferably metal-containing nanoparticles, and nanoparticles of biologically active organic molecules wherein the process is accomplished using the system.

    专利号:US-4337273-A
    优先权日:1980-05-15
    标 题:Methods of increasing coronary blood flow through vasodilation by flurbiprofen
    发明人:LEFER ALLAN M
    权利人:UNIV JEFFERSON
    摘要:Novel treatments are disclosed for increasing circulating coronary blood flow. These treatments are useful for individuals who are expected to otherwise exhibit symptoms of reduced coronary circulation. Such individuals include those having coronary artery disease, angina, particularly unstable angina and Prinzmetal's angina, and coronary vasospasm. In accordance with the disclosed methods, coronary vasodilation is accomplished through the administration of effective amounts of ibuprofen and/or flurbiprofen. At the indicated dosages, thromboxane synthesis is effectively inhibited without inhibiting prostacyclin synthesis. Flurbiprofen administration additionally results in thromboxane antagonism.

    专利号:US-2014026468-A1
    优先权日:2012-07-24
    标题:Control of Subterranean Termites
    发明人:HENDERSON GREGG; WANG CAI; GAUTAM BAL K
    权利人:HENDERSON GREGG; WANG CAI; GAUTAM BAL K; UNIV LOUISIANA STATE
    摘要:A biological control is disclosed for termites, including subterranean termites such as C. formosanus , comprising a mixture of a chitin synthesis inhibitor such as lufenuron with a pathogen or opportunistic pathogen. The combination greatly enhances the effectiveness above that of the individual components. For example, P. aeruginosa is commonly found in association with termites, but it is not normally harmful to termites. However, in the presence of lufenuron, P. aeruginosa becomes an opportunistic pathogen that kills termites. As another example, B. thuringiensis , which otherwise has shown only limited effectiveness against termites, has greatly enhanced lethality in combination with lufenuron. In another aspect a termite toxicant is administered to termites in a clay-based bait. Clay acts as an attractant for subterranean termites such as C. formosanus , and a clay bait can increase a colony's consumption of a toxicant.

    专利号:RU-2133733-C1
    优先权日:1992-12-02
    标题 :Method of synthesis of phenylpropionic acid

    专利号:US-6171617-B1
    优先权日:1996-02-20
    标 题 :Effervescent ibuprofen preparation and process for the production thereof
    发明人:GRUBER PETER
    权利人:LOSAN PHARMA GMBH
    摘要:In particular, the invention relates to a new, clearly dissolving ibuprofen effervescent formulation and a process for the preparation of this formulation. n Ibuprofen or (±)2-(4-isobutylphenyl)-propionic acid has the following structural formula n and has been for years a proven, non-steroidal antiphlogistic from the group of phenylpropionic acid derivatives, which shows effectiveness in veterinary experimental inflammation models by inhibiting prostaglandin synthesis.

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    品牌试剂参考报价(招募中)

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Moore RA, Derry S, Wiffen PJ, Straube S, Aldington DJ. Overview review: Comparative efficacy of oral ibuprofen and paracetamol (acetaminophen) across acute and chronic pain conditions. Eur J Pain. 2015 Oct;19(9):1213-23. doi: 10.1002/ejp.649. Epub 2014 Dec 22. Review. doi: 10.1002/14651858.CD011509.pub2. Review. doi: 10.1002/14651858.CD003481.pub6. Review. doi: 10.4097/kjae.2015.68.1.3. Epub 2015 Jan 28. Review.
    5: Kelly LE, Sommer DD, Ramakrishna J, Hoffbauer S, Arbab-Tafti S, Reid D, Maclean J, Koren G. Morphine or Ibuprofen for post-tonsillectomy analgesia: a randomized trial. Pediatrics. 2015 Feb;135(2):307-13. doi: 10.1542/peds.2014-1906.

    合成参考文献


    摘要:Pharmaceutical Sciences., 3(203), 1997
    参考文献:10.1016/s0014-2999(99)00246-0
    摘要:Al Rayyes O, Ahrén B, Florén CH. Enhancement of low density lipoprotein catabolism by non-steroidal anti-inflammatory drugs in cultured HepG2 cells. Eur J Pharmacol. 1999 May 21;372(3):311–8. doi: 10.1016/s0014-2999(99)00246-0.
    参考文献:10.1592/phco.19.10.854.31550
    摘要:Pérez-Gutthann S, García-Rodríguez LA, Duque-Oliart A, Varas-Lorenzo C. Low-dose diclofenac, naproxen, and ibuprofen cohort study. Pharmacotherapy. 1999 Jul;19(7):854–9. doi: 10.1592/phco.19.10.854.31550.
    摘要:Sanchez C, Mateus MM, Defresne MP, Crielaard JM, Reginster JY, Henrotin YE. Metabolism of human articular chondrocytes cultured in alginate beads. Longterm effects of interleukin 1beta and nonsteroidal antiinflammatory drugs. J Rheumatol. 2002 Apr;29(4):772–82.
    参考文献:10.1002/nur.20019
    摘要:McCarthy DO, Whitney P, Hitt A, Al‐Majid S. Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon‐26 adenocarcinoma. Research in Nursing & Health. 2004 May 06;27(3):174–84. doi: 10.1002/nur.20019.
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