CAS: 26759-46-6; Methyl 2-Amino-4,5-Dimethoxybenzoate

上下游产品

CAS号26791-93-5 4,5-二甲氧基-2-硝基苯甲酸甲酯 | CAS号2150-38-1 3,4-二甲氧基苯甲酸甲酯 | CAS号67-56-1 甲醇 | CAS号5653-40-7 2-氨基-4,5-二甲氧基苯甲酸 | CAS号50377-49-6 4-氯-6,7-二甲氧基-2-甲基喹唑啉 | CAS号5653-40-7 2-氨基-4,5-二甲氧基苯甲酸 | CAS号20197-86-8 2-氯-6,7-二甲氧基-1H... | CAS号214470-52-7 1,4-二氢-6,7-二甲氧基... | CAS号221698-39-1 4-氯-6,7-二甲氧基-2-喹唑啉胺 | CAS号35241-23-7 6,7-二甲氧基-2-甲基-4... | CAS号285138-76-3 2-[(2-氯乙酰基)氨基]-... | CAS号23680-84-4 4-氨基-2-氯-6, 7-二氧基喹唑啉 | CAS号31485-66-2 6,7-DIMETHOXY-3... | CAS号788136-89-0 4-(3-氯-4-氟苯氨基)-...

3,4-二甲氧基苯甲酸甲酯置于palladium On Activated Charcoal 氢气,硝酸体系中,化学反应 1.17H,反应生成2-氨基-4,5-二甲氧基苯甲酸甲酯
参考文献:4-氨基-2-氯-6,7-二甲氧基喹唑啉唑啉的快速,实用的大规模合成
标题:4-氨基-2-氯-6,7-二甲氧基喹唑啉唑啉的快速,实用的大规模合成
摘要:带有各种取代基的喹唑啉因其各种生物学特性而受到极大关注.目前用于治疗高血压的喹唑啉家族的重要药物是普鲁佐星,多沙唑星,四唑星,布那唑星,奈达唑嗪,后唑嗪和阿夫唑星.4-氨基-2-氯-6,7-二甲氧基喹唑啉 (8) 是这些通用抗高血压药物的常见前体.用于制备 4-氨基-2-氯-6,7-二甲氧基喹唑啉 (8) 的出版物*和随后的专利 3 信息涉及取代邻氨基苯甲酸或其酰胺与氰酸钠悬浮液的反应,然后用碱或酸得到取代的 2,4-二羟基喹唑啉 6. 6 与五氯化磷和三氯氧化磷在回流下反应反应生成2,4-二氯-6,7-二甲氧基喹唑啉 (7),通过在室温下在稀 Thf 中用无水氨处理将其转化为 8.结合我们的 (F)-Doxazocin Mesylate 工艺开发,我们有机会评估 8 的合成.在再现上述合成路线的过程中遇到了三个主要挑战:(I) 将香草醛 (1) 氧化为香草酸 (2) 使用传统方法,例如 Koh
Doi:10.1080/00304940409458676

专利信息

专利号:US-9452220-B2
优先权日:2014-12-23
标 题 :Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof
发明人：ZHANG YANMEI; DING KE; LIAO JINXI; WANG YICAN; CHEN PANYU
权利人:GUANGZHOU INST BIOMED & HEALTH
摘要:The present invention discloses coupling compounds of a structure as shown in Formula I, II or III formed by connecting NSAID anti-inflammatory and analgesic drugs and EGFR inhibitors by ester bonds or pharmaceutically acceptable salts or stereoisomers thereof or prodrug molecules thereof: n n n n n n n n n n n n where R is a NSAID anti-inflammatory and analgesic drug. In the present invention, the coupling compounds obtained by coupling NSAID anti-inflammatory and analgesic drugs with EGFR inhibitors have excellent therapeutic effects of tumors and provide new drugs for clinic treatment options.

专利号:US-2016175453-A1
优先权日:2014-12-23
标题 :Coupling compounds of nsaid anti-inflammatory and analgesic drugs and egfr kinase inhibitors, synthesis methods and applications thereof

专利号:CN-103483275-A
优先权日:2012-11-19
标 题 :Coupling compound of NSAID anti-inflammatory analgesic drug and EGFR kinase inhibitor and its synthesis method and application

专利号:CN-103483275-B
优先权日:2012-11-19
标题:Coupling compound of NSAID anti-inflammatory analgesic drug and EGFR kinase inhibitor and its synthesis method and application