CAS: 2631-72-3; 2-Bromo-1-(2,4-Dichlorophenyl)Ethanone

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CAS号2234-16-4 2,4-二氯苯乙酮 | CAS号60-29-7 乙醚 | CAS号7732-18-5 水 | CAS号24123-68-0 2,2-dibromo-1-(... | CAS号121-45-9 亚磷酸三甲酯 | CAS号104941-07-3 1-(2,4-dichloro... | CAS号104940-99-0 1-[3-(2,4-dichl... | CAS号39528-61-5 2,4-二氯苯甲腈 | CAS号141776-18-3 2-[2-(3,4-dichl... | CAS号46503-52-0 2'-(1H-咪唑-1-基)-... | CAS号187164-20-1 (1S)-2-Bromo-1-... | CAS号860439-01-6 (R)-2-bromo-1-(... | CAS号2234-16-4 2,4-二氯苯乙酮 | CAS号93209-97-3 4-(2,4-二氯苯基)噻唑-2-胺

2,4-二氯苯乙酮置于氢溴酸,溴,溶剂黄146体系中,化学反应生成2-溴-2',4'-二氯苯乙酮
参考文献:常规和微波促进芳基(烷基)唑肟的合成,E/z 异构体比的 1H-NMR 光谱测定和 Homo-Lumo 分析
标题:常规和微波促进芳基(烷基)唑肟的合成,E/z 异构体比的 1H-NMR 光谱测定和 Homo-Lumo 分析
摘要:本研究采用常规方法和微波辐射法合成了12种肟衍生物.目的是比较常规方法和微波方法的有效性.两种方法都测定了它们的收率,当使用微波方法时产率增加.含有肟的化合物由于具有碳氮双键而表现出几何异构现象.因此,我们还旨在在本研究中评估它们的e / Z异构体比率.虽然在两种合成方法中合成的吡唑衍生物化合物大多以z异构体形式获得,但观测到一些标题化合物几乎完全以e形式获得采用常规合成方法合成咪唑衍生物时的异构体.合成化合物的结构经ir,1 H-NMR,13 C-NMR和hrms谱确证.此外,在本研究中,12 种肟衍生物的e/z异构体的 Homo-Lumo 能量和热力学性质使用 6-31 * G 基组和密度泛函理论 (Dft) 计算使用 B3Lyp 方法进行了三种不同的计算.环境(水,乙醇,真空).此外,还有化学硬度(η),化学势(μ),亲电指数(ω),化学柔软度(σ )等几何参数) 是根据计算的 Homo-Lumo
Doi:10.1016/j.Molstruc.2021.132077

专利信息

专利号:WO-2021038581-A1
优先权日:2019-08-30
标题 :A one step synthesis of 2-substituted benzo[b]thiophenes
发明人：SEKAR GOVINDASAMY; POONGUZHALI ELAMVAZHUTHI
权利人:INDIAN INST TECH MADRAS
摘要:The invention pertains to a one step synthesis of 2-substituted benzo[ b ]thiophene of general formula wherein the synthesis of 2-substituted benzo[ b ]thiophenes is by reacting the starting materials substituted or unsubstituted 2-halogenobenzaldehyde and substituted or unsubstituted acetyl/phenacyl bromide with a catalyst, a sulphur source and phase transfer catalyst in an aqueous medium with atmospheric air and at temperature in the range of 25°C-30°C.

专利号:US-8829014-B2
优先权日:2006-04-07
标题 :Thiazole and thiophene analogues, and their use in treating autoimmune diseases and cancers
发明人：GIORDANO ANTHONY; VASU KAMALA K; THAKAR HARDIK M; GIRI RAJAN S; SUDARSANAM VASUDEVAN; YERANDE SWAPNIL G; INAMDAR GAJANAN S
权利人:GIORDANO ANTHONY; VASU KAMALA K; THAKAR HARDIK M; GIRI RAJAN S; SUDARSANAM VASUDEVAN; YERANDE SWAPNIL G; INAMDAR GAJANAN S; UNIV LOUISIANA STATE; PATEL PHARMACEUTICAL EDUCATION & RES DEV PERD CT B V
摘要:Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.

专利号:RU-2043342-C1
优先权日:1992-01-14
标题:Method of synthesis of 1-[2-(2,4-dichlorophenyl)-2- (2,4- dichlorophenylmethoxy)]- ethylimidazole nitrate

专利号:US-2010280046-A1
优先权日:2006-01-10
标题:Methods and Compositions for Treating Prostate Cancer, Benign Prostatic Hypertrophy, Polycystic Ovary Syndrome and Other Conditions
发明人：STEWART TIMOTHY ANDREW
权利人:DIOBEX INC
摘要:Pharmaceutical compositions comprising the 2S,4R ketoconazole enantiomer or its pharmaceutically acceptable salts, hydrates, and solvates, that are substantially free of the 2R,4S ketoconazole enantiomer are useful to reduce testosterone synthesis and for the treatment of prostate cancer, benign prostatic hyperplasia, seborrhea, hirsutism, alopecia, polycystic ovary syndrome, and other diseases and conditions, including but not limited to systemic hyperandrogenism.

专利号:US-2009298848-A1
优先权日:2006-04-18
标 题 :Methods and Compositions for Treating Barth Syndrome, Cardiomyopathy, Mitochondrial Diseases and Other Conditions
发明人：STEWART TIMOTHY ANDREW
权利人:CORTENDO INVEST AB
摘要:Pharmaceutical compositions comprising the 2S,4R ketoconazole enantiomer or its pharmaceutically acceptable salts, hydrates, and solvates are useful to increase cardiolipin synthesis and for the treatment of Barth Syndrome, diabetic myopathy, cardiomyopathy associated with aging, mitochondrial disease, and other conditions and disorders where cardiolipin deficiency plays a causative or symptomatic role.

专利号:CN-109879862-A
优先权日:2019-03-30
标 题 :A kind of synthesis technique of propiconazole