CAS: 24587-32-4; (2S,4R)-1-Glycyl-4-Hydroxypyrrolidine-2-Carboxylic Acid

上下游产品

N-(N-benzyloxycarbonylglycyl)-4-hydroxy-L-proline 4R-4-hydroxyproline cis-1-(N-benzyloxycarbonyl-glycyl)-4-hydroxy-L-prolinecis-1-(N-benzyloxycarbonyl-glycyl)-4-hydroxy-L-proline hydroxy L-proline

N-(N-Benzyloxycarbonylglycyl)-4-Hydroxy-L-Proline置于甲醇,钯,溶剂黄146体系中,化学反应生成(2S,4R)-1-(2-氨基乙酰基)-4-羟基吡咯烷-2-羧酸
参考文献:Smith; Bergmann,Journal Of Biological Chemistry,1944,Vol. 153,P. 627,649
标题:Smith; Bergmann,Journal Of Biological Chemistry,1944,Vol. 153,P. 627,649

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-9751911-B2
优先权日:2012-11-27
标 题:Solomonamide analogue compounds, pharmaceuticals containing solomonamide analogue compounds, and processes for the preparation thereof
发明人：REDDY DUMBALA SRINIVASA; KOMIRISHETTY KASHINATH; NATARAJAN VASUDEVAN
权利人:COUNCIL SCIENT IND RES
摘要:Solomanamide analogs of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogs, including the synthesis of macrocyclic core of Salomanamide analogs. The Solomanamide analogs of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.

专利号:US-2786049-A
优先权日:1956-02-20
标 题:Synthesis of peptide structures
发明人：LUNDGREN HAROLD P; WALDEN MAYO K; GORDON ROSE WILLIAM
权利人:LUNDGREN HAROLD P; WALDEN MAYO K; GORDON ROSE WILLIAM

专利号:IL-142499-A
优先权日:1994-06-08
标题 :Building units for synthesis of backbone cyclized peptide analogs

专利号:US-6265375-B1
优先权日:1994-06-08
标题 :Conformationally constrained backbone cyclized peptide analogs
发明人：GILON CHAIM; EREN DORON; ZELTSER IRINA; SERI-LEVY ALON; BITAN GAL; MULLER DAN
权利人:YISSUM RES DEV CO; PEPTOR LTD
摘要:Novel backbone cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units disclosed are Nalpha(omega-functionalized) amino acids constructed to include a spacer and a terminal functional group. One or more of these Nalpha(omega-functionalized) amino acids are incorporated into a peptide sequence, preferably during solid phase peptide synthesis. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. The invention is specifically exemplified by backbone cyclized bradykinin antagonists having biological activity. Further embodiments of the invention are somatostatin analogs having one or two ring structures involving backbone cyclization.