异氰酰乙酸乙酯置于甲酸,三乙胺体系中,用 四氢呋喃 用作溶剂,化学反应 1.5H,以84%的收率获得4-恶唑甲酸乙酯 参考文献: Bicyclononene Derivatives As Renin Inhibitors[fr] Dérivés Du Bicyclononène Employés En Tant Qu'Inhibiteurs De La Rénine 标题: Bicyclononene Derivatives As Renin Inhibitors[fr] Dérivés Du Bicyclononène Employés En Tant Qu'Inhibiteurs De La Rénine 摘要:该发明涉及公式(i)的新型双环庚烯衍生物;以及其作为药物组合物中活性成分的用途.该发明还涉及相关方面,包括制备化合物的方法,含有其中一种或多种化合物的药物组合物,特别是它们作为肾素抑制剂的用途.
专利号:US-2008200475-A1 优先权日:2005-03-28 标题:4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors 发明人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH 权利人:PFIZER 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: (I) wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2a , R x , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.