CAS: 220394-91-2; Benzyl4-Isocyanatotetrahydro-1(2H)-Pyridinecarboxylate
化学文摘社编号为220394-91-2,便于在化学数据库中识别,便利在诸如医药化学和材料科学等领域的研究和应用;妥善处理和安全防范对于与异丙酸有关的潜在毒性至关重要.
- 英文名称Benzyl4-Isocyanatotetrahydro-1(2H)-Pyridinecarboxylate
- 中文名称4-异硫氰四羟基-1(2H)-吡啶甲酸苄酯
- IUPAC名称benzyl 4-isocyanatopiperidine-1-carboxylate
- 其它别名Benzyl 4-Isocyanatotetrahydro-1(2H)-Pyridinecarboxylate; Buttpark 75\50-49; Benzyl 4-Isocyanatopiperidine-1-Carboxylate; 1-Cbz-4-Isocyanatopiperidine; 4-Isocyanatopiperidine, N-Cbz Protected; 4-Isocyanato-2-Piperidinecarboxylic Acid (Phenylmethyl) Ester; 1-Piperidinecarboxylicacid, 4-Isocyanato-, Phenylmethyl Ester
- CAS编号220394-91-2
- MFCD编号:MFCD02681988
- EINECS号:641-318-5
- 分子式:C14H16N2O3分子量:260.29
- 产品CID: 1143410
- 产品分类医药中间体 → 吡啶类化合物
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号10314-98-4 N-Cbz-哌啶-4-羧酸 | CAS号501-53-1 氯甲酸苄酯 | CAS号10314-99-5 N-Cbz-哌啶-4-甲酰氯 | CAS号313977-45-6 叔丁基乙基(哌啶-4-基)氨基甲酯 | CAS号73874-95-0 4-B°C-氨基哌啶 | CAS号159874-20-1 1-CBZ-4-B°C-氨基哌啶 | CAS号164518-96-1 3-(4-Piperidiny...合成工艺路线路线简述
- 合成目标产物 Benzyl 4-Isocyanatotetrahydro-1(2H)-Pyridinecarboxylate 主要起始原料 1-[(Benzyloxy)Carbonyl]Piperidine-4-Carboxylic Acid
- (文献来源)合成步骤主要原料 1-[(Benzyloxy)Carbonyl]Piperidine-4-Carboxylic Acid
📜4-氯羰酰四氢-吡啶羧酸苄酯置于sodium Azide体系中,用 丙酮,甲苯 用作溶剂,化学反应生成4-异硫氰四羟基-1(2H)-吡啶甲酸苄酯
参考文献:Antagonists Of The Human Ccr5 Receptor As Anti-Hiv-1 Agents. Part 4: Synthesis And Structure-activity Relationships For 1-[n-(Methyl)-N-(Phenylsulfonyl)Amino]-2-(Phenyl)-4-(4-(N-(Alkyl)-N-(Benzyloxycarbonyl)Amino)Piperidin-1-yl)Butanes
标题:Antagonists Of The Human Ccr5 Receptor As Anti-Hiv-1 Agents. Part 4: Synthesis And Structure-activity Relationships For 1-[n-(Methyl)-N-(Phenylsulfonyl)Amino]-2-(Phenyl)-4-(4-(N-(Alkyl)-N-(Benzyloxycarbonyl)Amino)Piperidin-1-yl)Butanes
摘要:(2S)-2-(3-氯苯基)-1-[n-(甲基)-N-(苯磺酰基)氨基]-4-[螺环(2,3-二氢苯并噻吩-3,4'-哌啶-1'-基)]丁烷 S-氧化物 (Lb) 已被鉴定为一种强效的 Ccr5 拮抗剂,其 Ic50 = 10 Nm.在此,描述了非螺环哌啶的结构-活性关系研究,这些研究导致了发现 4-(N-(烷基)-N-(苯甲酰氧基)氨基)哌啶衍生物 (3-5) 作为强效的 Ccr5 拮抗剂.(C) 2001 Elsevier Science Ltd. 保留所有权利.
Doi:10.1016/s0960-894X(01)00492-9
海关参考信息
- 2902300000-甲苯
2906210000-苄醇
2912110000-甲醛
2915110000-甲酸 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:An Automated, Polymer-Assisted Strategy For The Preparation Of Urea And Thiourea Derivatives Of 15-Membered Azalides As Potential Antimalarial Chemotherapeutics作者:Antun Hutinec,Renata Rupčić,Dinko žiher,Kirsten S. Smith,Wilbur Milhous,William Ellis,Colin Ohrt,Zrinka Ivezić Schönfeld |发布日期:2011.3
摘要:Series Of 15-Membered Azalide Urea And Thiourea Derivatives Has Been Synthesized And Evaluated For Their In Vitro Antimalarial Activity Against Chloroquine-Sensitive (D6), Chloroquine/pyremethamine Resistant (W2) And Multidrug Resistant (Tm91C235) Strains Of Plasmodium Falciparum. We Have Developed An Effective Automated Synthetic Strategy For The Rapid Synthesis Of Urea/thiourea Libraries Of A Macrolide
合成参考文献
合成方法参考DOI号:10.1002/anie.201807393
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