CAS: 2124-31-4; 1-(4-(Dimethylamino)Phenyl)Ethanone

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📜在 四氯化碳体系中,用 甲醇 用作溶剂,化学反应生成二甲氨基苯乙酮
参考文献:时间分辨荧光和瞬态光谱测定溶液和微非均质介质中反应系统中的光化学和光物理通道
标题:时间分辨荧光和瞬态光谱测定溶液和微非均质介质中反应系统中的光化学和光物理通道
摘要:摘要:已使用时间分辨光谱技术对均质和微异质系统中的短寿命中间体进行表征.从这些技术中获得的数据已经以一种相对非常规的方式进行了分析,以阐明两个反应系统的复杂瞬态行为.已经使用寿命分布分析 (Dla) 分析了一系列易于在水性介质中形成双层系统的 Fraws-芪衍生的两亲物的高度非指数荧光衰减.Dla 用于定量研究的效用首先是通过模拟人工衰减数据来确定的.尽管 Dla 存在一些限制,当还考虑诸如稳态光谱数据之类的补充信息时,可以得出关于荧光物质性质的定性结论.结果表明,观测到的荧光来自不同类型的激发态物质,这些物质由两个或多个反式二苯乙烯单元组成;其中一个排放归因于基态聚集体的激发态,而另一个归因于可能由双层中的"缺陷"引起的准分子.衰变的非指数性质归因于荧光物质所经历的环境分布.已经发现溶液中几种激发的频哪醇和四氯化碳之间的电子转移 (Et) 反应产生的产物的量子产率在氧气存在下高于 1,提
Doi:10.1111/j.1751-1097.1997.Tb01873.X

专利信息

专利号:US-6413957-B1
优先权日:1998-04-21
标题:Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
权利人:BRISTOL MYERS SUIBB PHARMA COM
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-6541276-B2
优先权日:1996-10-28
标题:Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof
发明人：PATEL DINESH V; NGU KHEHYONG
权利人:VERSICOR INC
摘要:A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteases).

专利号:US-7250435-B2
优先权日:1999-10-20
标 题:Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP P; YUE EDDY
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n nthat are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.n n This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-6407103-B2
优先权日:1998-04-21
标 题:Indeno [1,2-c] pyrazol-4-ones and their uses
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-6593356-B2
优先权日:1999-10-20
标 题 :Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
发明人：NUGIEL DAVID; CARINI DAVID; DIMEO SUSAN; VIDWANS ANUP; YUE EDDY
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:CN-107417609-A
优先权日:2017-06-23
标 题 :Synthesis of a Novel Fluorescent Nucleus Containing a Quinoline Ring