CAS: 202534-94-9; Ethyl 4-(4-Fluorophenyl)-1-Methyl-2,6-Dioxopiperidine-3-Carboxylate

上下游产品

CAS号71510-95-7 N-甲基丙二酸单乙酯单酰胺 | CAS号459-57-4 对氟苯甲醛 | CAS号391937-08-9 trans-3-ethoxyc... | CAS号74-88-4 碘甲烷 | CAS号318279-38-8 反式-4-(4-氟苯基)-3-...

📜N-甲基丙二酸单乙酯单酰胺,对氟苯甲醛置于sodium Methylate,溶剂黄146体系中,用 水,乙酸乙酯 用作溶剂,化学反应生成4-(4-氟苯基)-1-甲基-2,6-二氧代哌啶-3-羧酸乙酯
参考文献:Process For Preparing Aryl-Piperidine Carbinols And Novel Intermediates
标题:Process For Preparing Aryl-Piperidine Carbinols And Novel Intermediates
摘要:公开了一种制备化合物的过程,其化学式为(I):其中ar是芳基或取代芳基,R.Sup.3是氢,烷基或芳基烷基,该过程包括还原化合物的过程的化学式(II):其中ar和r.Sup.3如与式(I)相关定义,R.Sup.4是烷基.化合物的化学式(I)可用作化学中间体.

专利信息

专利号:WO-2015071831-A1
优先权日:2013-11-18
标 题 :An improved process for minimising the formation of dehalogenated byproducts
发明人：KADAM SHASHIKANT; ARADDY RAJSHEKAR; KONDRAGUNTA VENKATESWARA RAO; HULAVALE YOGESH; SOMISETTI NARENDER RAO; CHENNAMSETTY SUNEEL MANOHAR BABU; HARIHARAN SIVARAMAKRISHNAN
权利人:PIRAMAL ENTPR LTD
摘要:The present invention provides an improved process for preparation of organic compounds represented by Formula-Z; wherein effectively minimising the formation of dehalogenated by-products is achieved. In the process, the reduction is carried out using suitable reducing agent; more preferably Lithium Aluminium Hydride (LAH) in a solvent system, wherein at least one of the solvent is selected from halogenated solvents, which acts as co-solvent. The process of the present invention is useful for minimising of the formation of dehalogenated by-products during synthesis of various active pharmaceutical ingredients such as Paroxetine Hydrochloride, Cinacalcet, Eletriptan and Asenapine.

专利号:US-2001053862-A1
优先权日:1998-12-22
标 题:Process for preparing arylpiperidine carbinol intermediates and derivatives
发明人：RONSEN BRUCE; UPADHYAYA SUBHASH P
摘要:A process for the synthesis of arylpiperidine carbinol intermediates and derivatives is disclosed. A preferred process embodiment provides the synthesis of intermediate compounds of structural formula (I) and structural formula (II): n n n where X is halo, C 1 -C 10 alkoxy, C 1 -C 10 haloalkyl, or hydroxy; R 2 and R 3 are each C 1 -C 4 alkyl, and R 2 and R 3 are the same. The compound of structural formula (I) is made by condensing a corresponding cinnamonitrile with a corresponding diester malonate. The compound of structural formula (II) in the (±)-trans configuration is obtained by hydrogenating the compound of structural formula (I). The compounds of structural formula (I) and structural formula (II) are useful chemical intermediates for synthesizing 4-arylpiperidine-3-carbinols and their derivatives in (−)-trans configuration.

专利号:WO-2009005647-A2
优先权日:2007-06-27
标 题 :Compounds and process to prepare chiral intermediates for synthesis of paroxetine