专利号:US-7064133-B2 优先权日:2001-10-12 标 题:Quinoline derivatives process of synthesis and medicaments containing these derivatives 发明人:D ANGELO JEAN; BENARD CHRISTOPHE; DANET MICHELE; LE BRET MARC; MOUSCADET JEAN-FRANCOIS; ZOUHIRI FATIMA; BAYLE MARIE; DESMAELE DIDIER; JEANSON LAURENCE; LEH HERVE; SUBRA FREDERIC 权利人:CENTRE NAT RECH SCIENT 摘要:The invention relates to derivatives corresponding to formula I: n nin whichn X is an alkyl-(CH 2 ) n — chain with n=0, 1 or 2, or O or N, Z is an aromatic which may contain heteroatoms chosen from O, N or S, as substitutions for the carbon atoms constituting said aromatic ring, this ring being substituted or otherwise with Rb, Rb represents 1 to 3 substituents chosen from —OH, —OR, —COOH, —COOR, —COH, —COR, —NH 2 , —NH(R), —NH(R,R′), —SH, —SR and CN, Ra is H or —(CH 2 ) n′ —Y, with n′=0, 1, 2 or 3 and Y and —CH 3 , —COOH, —COOR, —CN, —OH, —OR, SR, or an aryl group optionally substituted with Rb, R and R′ represent a linear or branched alkyl chain of 1 to 4 C, and their pharmaceutically acceptable salts. Application as active ingredient of medicaments inhibiting retrovirus integrases.
专利号:WO-2017156194-A1 优先权日:2016-03-08 标题:Compositions and methods for inhibiting influenza rna polymerase pa endonuclease 发明人:PUERTA DAVID T; COHEN SETH M; CREDILLE CY V 权利人:UNIV CALIFORNIA; PUERTA DAVID T 摘要:There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.
专利号:US-10889556-B2 优先权日:2016-03-08 标题 :Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease 发明人:COHEN SETH M; CREDILLE CY V; PUERTA DAVID T 权利人:UNIV CALIFORNIA 摘要:There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.
专利号:US-2006148849-A1 优先权日:2001-10-12 标题:Quinoline derivatives, process of synthesis and medicaments containing these derivatives
专利号:US-2004259911-A1 优先权日:2001-10-12 标 题:Quinoline derivatives process of synthesis and medicaments containing these derivatives
专利号:ES-2326115-T3 优先权日:2001-10-12 标题 :DERIVATIVES OF QUINOLEINE, SYNTHESIS PROCEDURE, AND MEDICATIONS CONTAINING THESE DERIVATIVES.
摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp. 参考文献:10.1016/j.bmcl.2006.08.040 摘要:Warshakoon NC, Wu S, Boyer A, Kawamoto R, Sheville J, Renock S, Xu K, Pokross M, Zhou S, Winter C, Walter R, Mekel M, Evdokimov AG. Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors. Bioorg Med Chem Lett. 2006 Nov 01;16(21):5517–22. doi: 10.1016/j.bmcl.2006.08.040.