CAS: 19829-79-9; 8-Hydroxy-7-Quinolinecarboxylic Acid

该化合物是一种有机化合物,其特征是附于quinoline结构的氢氧化物和碳oxy酸功能组,该化合物一般是晶体固体,以其在各个领域的潜在用途而著称,包括药物和分析化学.它具有诸如极地溶剂溶解性等特性,可以促进其在各种化学反应和配方中使用.该液态组的存在有助于其形成氢联结的能力,增强它与其他分子的再活性和相互作用.此外,氢丙烯酸可以作为一种与金属离子结合的切合剂,在生物系统和工业过程中都具有价值.其纯度通常为98%,表明其纯度为适于研究和应用的高质量.应当参考安全数据,以了解其处理和潜在危害,如任何化学物质.

结构式图片

相似化合物

5683-78-3 73776-20-2 55477-70-8

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号148-24-3 8-羟基喹啉 | CAS号124-38-9 二氧化碳 | CAS号37407-37-7 potassium 8-hyd... | CAS号205040-59-1 5-溴-8-羟基喹啉-7-羧酸 | CAS号205040-37-5 N-hexyl-8-hydro... | CAS号148-24-3 8-羟基喹啉 | CAS号630414-70-9 8-苄氧基喹啉-7-羧酸

合成工艺路线路线简述

  • 合成目标产物 8-Hydroxyquinoline-7-Carboxylic Acid 主要起始原料 8-Hydroxyquinoline And Carbon Dioxide
  • (文献来源)合成步骤主要原料 8-Hydroxyquinoline 和 Carbon Dioxide
📜8-羟基喹啉酸钾 以 水,N,N-二甲基甲酰胺 用作溶剂,以30.4%的收率获得8-羟基喹啉-7-羧酸
参考文献:Aroylaniline Compounds,Pharmaceutical Compositions,And Methods Of
标题:Aroylaniline Compounds,Pharmaceutical Compositions,And Methods Of
摘要:Aroylaniline化合物具有抗逆转录病毒活性,含有这种aroylaniline化合物的制药组合物以及治疗逆转录病毒感染的宿主的方法,包括向宿主投与抗病毒有效量的aroylaniline化合物.

海关参考信息

专利信息


专利号:US-7064133-B2
优先权日:2001-10-12
标 题:Quinoline derivatives process of synthesis and medicaments containing these derivatives
发明人:D ANGELO JEAN; BENARD CHRISTOPHE; DANET MICHELE; LE BRET MARC; MOUSCADET JEAN-FRANCOIS; ZOUHIRI FATIMA; BAYLE MARIE; DESMAELE DIDIER; JEANSON LAURENCE; LEH HERVE; SUBRA FREDERIC
权利人:CENTRE NAT RECH SCIENT
摘要:The invention relates to derivatives corresponding to formula I: n nin whichn X is an alkyl-(CH 2 ) n — chain with n=0, 1 or 2, or O or N, Z is an aromatic which may contain heteroatoms chosen from O, N or S, as substitutions for the carbon atoms constituting said aromatic ring, this ring being substituted or otherwise with Rb, Rb represents 1 to 3 substituents chosen from —OH, —OR, —COOH, —COOR, —COH, —COR, —NH 2 , —NH(R), —NH(R,R′), —SH, —SR and CN, Ra is H or —(CH 2 ) n′ —Y, with n′=0, 1, 2 or 3 and Y and —CH 3 , —COOH, —COOR, —CN, —OH, —OR, SR, or an aryl group optionally substituted with Rb, R and R′ represent a linear or branched alkyl chain of 1 to 4 C, and their pharmaceutically acceptable salts. Application as active ingredient of medicaments inhibiting retrovirus integrases.

专利号:WO-2017156194-A1
优先权日:2016-03-08
标题:Compositions and methods for inhibiting influenza rna polymerase pa endonuclease
发明人:PUERTA DAVID T; COHEN SETH M; CREDILLE CY V
权利人:UNIV CALIFORNIA; PUERTA DAVID T
摘要:There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.

专利号:US-10889556-B2
优先权日:2016-03-08
标题 :Compositions and methods for inhibiting influenza RNA polymerase PA endonuclease
发明人:COHEN SETH M; CREDILLE CY V; PUERTA DAVID T
权利人:UNIV CALIFORNIA
摘要:There are provided inter alia metalloenzyme inhibitors, such as inhibitors of influenza A RNA dependent RNA polymerase PA subunit endonuclease, and methods of synthesis and use of the same.

专利号:US-2006148849-A1
优先权日:2001-10-12
标题:Quinoline derivatives, process of synthesis and medicaments containing these derivatives

专利号:US-2004259911-A1
优先权日:2001-10-12
标 题:Quinoline derivatives process of synthesis and medicaments containing these derivatives

专利号:ES-2326115-T3
优先权日:2001-10-12
标题 :DERIVATIVES OF QUINOLEINE, SYNTHESIS PROCEDURE, AND MEDICATIONS CONTAINING THESE DERIVATIVES.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 2004. Toxicity, Repellency of Phytotoxicity of 979 Chemicals to Birds, Mammals and Plants. Research Report No. 04-01. National Wildlife Research Center, Fort Collins, Colorado. 118 pp.
参考文献:10.1016/j.bmcl.2006.08.040
摘要:Warshakoon NC, Wu S, Boyer A, Kawamoto R, Sheville J, Renock S, Xu K, Pokross M, Zhou S, Winter C, Walter R, Mekel M, Evdokimov AG. Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors. Bioorg Med Chem Lett. 2006 Nov 01;16(21):5517–22. doi: 10.1016/j.bmcl.2006.08.040.
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