CAS: 1585-16-6; Alpha-2-Chloroisodurene

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上下游产品

CAS号4170-90-5 2,4,6-三甲基苄醇 | CAS号50-00-0 甲醛 | CAS号108-67-8 均三甲苯 | CAS号3188-13-4 氯甲基乙醚 | CAS号107-30-2 氯甲基甲醚 | CAS号7093-91-6 CHLOROMETHYL IS... | CAS号527-53-7 1,2,3,5-四甲基苯 | CAS号7647-01-0 盐酸 | CAS号64-19-7 冰醋酸 | CAS号63548-92-5 acetic acid,(2,... | CAS号112247-46-8 1-phenyl-2-(2,4... | CAS号4408-60-0 均三甲苯基乙酸 | CAS号4674-23-1 1,3,5-trimethyl... | CAS号527-53-7 1,2,3,5-四甲基苯 | CAS号34688-71-6 2,4,6-三甲基苯乙腈 | CAS号40393-99-5 2,4,6-三甲基苄胺 | CAS号4170-90-5 2,4,6-三甲基苄醇 | CAS号41717-26-4 1-(2,4,6-三甲基苄基)哌嗪 | CAS号487-68-3 2,4,6-三甲基苯甲醛 | CAS号195259-08-6 4-(2,4,6-trimet...

2,4,6-三甲基苄醇置于氯化亚砜体系中,用 二氯甲烷 用作溶剂,化学反应生成2,4,6-三甲基氯苄
参考文献:小的伯烷基胺在骨架功能化膦(yphos)中通过骨架修饰的选择性pd催化的单芳基化.
标题:小的伯烷基胺在骨架功能化膦(yphos)中通过骨架修饰的选择性pd催化的单芳基化.
摘要:在温和的反应条件下,Ylide取代的膦是c-n偶联反应的非常好配体.在这里,我们报告了对叶立德骨架中取代基的空间需求对催化活性的影响的研究.合成了两个具有庞大邻甲苯基(pinkyphos)和三甲苯基(mesyphos)取代基的新型yphos配体,这些配体在空间上比其苯基类似物要高一些,但柔韧性要差得多.与以前报道的yphos配体相比,配体设计的这种变化导致小型伯胺的芳基化反应具有更高的选择性和产率.甚至menh 2和etnh 2在室温下也可以与一系列芳基氯高产率地偶联.
Doi:10.1021/acs.Joc.0C01771

专利信息

专利号:US-5618944-A
优先权日:1993-05-05
标题:Method for the synthesis of anthrapyrazolones
发明人：ZHANG LIN-HUA; AUERBACH JOSEPH
权利人:DU PONT MERCK PHARMA
摘要:This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphenyl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.

专利号:EP-0700390-A1
优先权日:1993-05-05
标 题 :Intermediates and methods for the synthesis of anthrapyrazolone anticancer agents

专利号:CN-1122597-A
优先权日:1993-05-05
标题 :Intermediates and methods for the synthesis of anthrapyrazolone anticancer agents

专利号:WO-9425441-A1
优先权日:1993-05-05
标 题:Intermediates and methods for the synthesis of anthrapyrazolone anticancer agents

专利号:EP-0700390-B1
优先权日:1993-05-05
标 题:Intermediates and methods for the synthesis of anthrapyrazolone anticancer agents

专利号:EP-1344772-B1
优先权日:2000-12-15
标题 :Arylbis (perfluoroalkylsulfonyl) methane, metal salt of the same, and processes for producing these
发明人：ISHIHARA KAZUAKI; YAMAMOTO HISASHI
权利人:JAPAN SCIENCE & TECH AGENCY
摘要:A process for highly efficiently producing various arylbis(perfluoroalkylsulfonyl)methanes which have a bulky aryl group or electron-attracting aryl group and which have conventionally been regarded as difficult to synthesize; a novel arylbis(perfluoroalkylsulfonyl)methane widely applicable as a catalyst for asymmetric synthesis, various functional materials, etc.; metal salts of these; and an excellent catalyst. An arylhalomethane is reacted with sodium trifluoromethanesulfinate. The arylmethyltrifluorocarbon yielded is reacted with t-BuLi, etc. The arylmethyltrifluorocarbon lithium salt obtained is reacted with trifluoromethanesulfonic anhydride. Thus, an arylbis(trifluoromethylsulfonyl)methane, e.g., pentafluorophenylbis(trifuryl)methane or {4-(pentafluorophenyl)-2,3,5,6-tetrafluorophenyl}bis(trifuryl)methane, is obtained in high yield.