CAS: 145195-63-7; (Z)-Entacapone
- 英文名称(Z)-Entacapone
- 中文名称(2Z)-2-氰基-3-(3,4-二羟基-5-硝基苯基)-N,N-二乙基-2-丙烯酰胺
- IUPAC名称(Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide
- 其它别名(2Z)-2-Cyano-3-(3,4-Dihydroxy-5-Nitrophenyl)-N,N-Diethyl-2-Propenamide; (Z)-Entacapone; Cis-Entacapone; Entacapone Impurity A -I; (Z)-2-Cyano-3-(3,4-Dihydroxy-5-Nitrophenyl)-N,N-Diethylprop-2-Enamide; Entacapone Impurity 17(Entacapone Ep Impurity A); Entacapone Related Compound A (25 Mg) ((Z)-2-Cyano-3-(3,4-Dihydroxy-5-Nitrophenyl)-N,N-Diethylacrylamide); Entacapone Ep Impurity A
- CAS编号145195-63-7
- MFCD编号:MFCD00869878
- FDA UNII编号:4X96VV9HUQ
- 分子式:C14H15N3O5分子量:305.29
- 产品CID: 687796
- 同类组份化合物CAS130929-57-6 (E isomer)145195-63-7 (Z isomer)
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
130929-57-6 857629-79-9 1364322-41-7物理性质
MSDS等安全信息
上下游产品
CAS号26391-06-0 N,N-二乙基氰乙酰胺 | CAS号116313-85-0 3,4-二羟基-5-硝基苯甲醛 | CAS号146698-91-1 (E/Z)-3-O-Methy... | CAS号686349-59-7 entacapone | CAS号130929-57-6 恩他卡朋合成工艺路线路线简述
📜Entacapone 以 甲苯 用作溶剂,化学反应 4.0H,反应生成(2Z)-2-氰基-3-(3,4-二羟基-5-硝基苯基)-N,N-二乙基-2-丙烯酰胺
参考文献:Wo2007/94007
标题:Wo2007/94007
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902300000-甲苯
2902500000-苯乙烯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2008098960-A1
优先权日:2007-02-13
标 题:Process for preparing entacapone substantially free of z-isomer, synthesis intermediates thereof and a new crystalline form
专利号:US-2009326062-A1
优先权日:2007-02-13
标 题 :Process for preparing entacapone substantially free of z-isomer, synthesis intermediates thereof and a new crystalline form
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主要参考文献
1. Wikberg, T., Vuorela, A., Ottoila, P., et al. Identification of major metabolites of the catechol-O-methyltransferase inhibitor entacapone in rats and humans. Drug Metab. Dispos. 21(1), 81-92 (1993). 2. Tekale, P., Tekale, S., and Mhatre, V.S. Determination of impurities in formulated form of entacapone by RP-HPLC method. Der Pharma Chemica 3(5), 63-68 (2011). 3. Soukhova, N.S., Kassymbek, Z., Bradby, S., et al. Development of characterization methods for entacapone in a pharmaceutical bulk. J. Pharm. Biomed. Anal. 54(4), 860-865 (2011).合成参考文献
摘要:S113 | SWISSPHARMA24 | 2024 Swiss Pharmaceutical List with Metabolites | DOI:10.5281/zenodo.10501043
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