CAS: 14381-42-1; 1-Indanecarboxylic Acid

该化合物是一种含有分子式C10H10O2的双环芳烃式的箱式碳酸,它是有机合成的多用途中间体,特别是在制备药品,农用化学品和精美化学品方面.硬性坚硬的坚固的坚固的坚固坚固坚固的坚固坚固的坚固坚固坚固的坚固坚固的坚固坚固结构为设计生物活性化合物提供了宝贵条件.它的软体酸功能允许进一步衍生,包括酯化,恐吓或减少.复合体在有机溶剂中表现出中等溶解性,便于在各种反应条件下使用.它具有明确界定的结构和合成的无障碍性,使它成为医学和材料化学研究人员的一个实用建筑块.

结构式图片

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上下游产品

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合成工艺路线路线简述

    📜Indan-1-Carboxylic Acid Ethyl Ester置于sodium Hydroxide体系中,化学反应生成2,3-二氢-1H-茚-1-羧酸
    参考文献:Umsetzungen Der 1:2-Benzocyclenyl-3-Methylamine Mit Salpetrigersäure
    标题:Umsetzungen Der 1:2-Benzocyclenyl-3-Methylamine Mit Salpetrigersäure
    摘要:[1:2-苯并环烯基-3-甲基]-重氮离子在乙酸中的分解产生3-羟甲基-1:2-苯并环戊烯-1(iv)的乙酸酯以及环扩大的3-和4-羟基-1:2-苯并环戊酮-1(viii和vi).这些产物的比例在很大程度上取决于环的尺寸.伯碳鎓离子xi似乎可以作为第一中间体.讨论了对芳基和烷基迁移程度的构象控制.
    Doi:10.1016/s0040-4020(01)98625-9

    海关参考信息

    专利信息


    专利号:US-4777257-A
    优先权日:1983-08-25
    标题:Certain tetrahydronaphthyl or indanylcarboxylates and derivatives thereof which inhibit the synthesis of thromboxane
    发明人:KANAO MUNEFUMI
    权利人:DAIICHI SEIYAKU CO
    摘要:Benzocycloalkane derivatives of the formula (I) ##STR1## wherein: Z represents a methylene group or an ethylene group, either one of R 1 and R 2 represents --(CH 2 ) m --COOR 3 and the other represents ##STR2## wherein R 3 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, n represents an interger of 1 to 6 and m represents an interger of 0 to 5, and the physiologically acceptable salts thereof; having a strong and selective inhibition activity of thromboxane A 2 synthesis.

    专利号:US-10899695-B2
    优先权日:2017-02-06
    标 题 :Process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes
    发明人:MCLAREN LEE; TO DANIEL; TOVELL DAVID; ABELE STEFAN
    权利人:IDORSIA PHARMACEUTICALS LTD
    摘要:The present invention relates to a process for the manufacturing of 1-aryl-1-trifluoromethylcyclopropanes, which serve as intermediates for the manufacturing of calcium T channel blockers of the general formula (A) n nwhich are described in WO 2015/186056.

    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-2023279170-A1
    优先权日:2022-03-02
    标 题:Chiral-substituted poly-n-vinylpyrrolidinones and complexes with bimetallic nanoclusters and uses thereof
    发明人:HUA DUY H
    权利人:UNIV KANSAS STATE
    摘要:Synthesis of chiral polyvinylpyrrolidinone (CSPVP) compounds, complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and selective C—H bond oxidation reactions utilizing such complexes are disclosed. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products.

    专利号:US-2019375702-A1
    优先权日:2017-02-06
    标 题 :A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes

    专利号:US-5959159-A
    优先权日:1997-10-24
    标题 :Method for preparing optically active 5-hydroxy-3-(4'-hydroxyphenyl)-1,1,3-trimethylindane
    发明人:KAZLAUSKAS ROMAS JOSEPH; ZHANG XIAOMING
    权利人:MOLECULAR OPTOELECTRONICS CORP
    摘要:A process for resolving racemic diesters of (R,S)(±)-5-hydroxy-3-(4'-hydroxyphenyl)-1,1,3-trimethylindane is disclosed. The process utilizes a microbial enzyme derived from Chromobacterium viscosum to catalyze the enantioselective and regioselective hydrolysis of the (S)(-)-enantiomer of the racemic mixture to its corresponding monoester at a faster rate than the (R)(+)-enantiomer. A substantially pure (S)(-)-indane monoester is thereby formed, while the (R)(+)-indane diester remains unreacted. The (S)(-)-monoester and the (R)(+)-diester can then be hydrolyzed using conventional techniques to form optically active (R)(+)- and (S)(-)-5-hydroxy-3-(4'-hydroxyphenyl)-1,1,3-trimethylindane enantiomers for use as monomers in the synthesis of chiral polymers.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Indian Journal of Physiology and Pharmacology., 24(310), 1980 []
    摘要:Cunha, J. C.; Dedeiras, B.; Negrão, A. C. R.; Marques, M. M. B., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .
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