📜Indan-1-Carboxylic Acid Ethyl Ester置于sodium Hydroxide体系中,化学反应生成2,3-二氢-1H-茚-1-羧酸 参考文献:Umsetzungen Der 1:2-Benzocyclenyl-3-Methylamine Mit Salpetrigersäure 标题:Umsetzungen Der 1:2-Benzocyclenyl-3-Methylamine Mit Salpetrigersäure 摘要:[1:2-苯并环烯基-3-甲基]-重氮离子在乙酸中的分解产生3-羟甲基-1:2-苯并环戊烯-1(iv)的乙酸酯以及环扩大的3-和4-羟基-1:2-苯并环戊酮-1(viii和vi).这些产物的比例在很大程度上取决于环的尺寸.伯碳鎓离子xi似乎可以作为第一中间体.讨论了对芳基和烷基迁移程度的构象控制. Doi:10.1016/s0040-4020(01)98625-9
专利号:US-4777257-A 优先权日:1983-08-25 标题:Certain tetrahydronaphthyl or indanylcarboxylates and derivatives thereof which inhibit the synthesis of thromboxane 发明人:KANAO MUNEFUMI 权利人:DAIICHI SEIYAKU CO 摘要:Benzocycloalkane derivatives of the formula (I) ##STR1## wherein: Z represents a methylene group or an ethylene group, either one of R 1 and R 2 represents --(CH 2 ) m --COOR 3 and the other represents ##STR2## wherein R 3 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, n represents an interger of 1 to 6 and m represents an interger of 0 to 5, and the physiologically acceptable salts thereof; having a strong and selective inhibition activity of thromboxane A 2 synthesis.
专利号:US-10899695-B2 优先权日:2017-02-06 标 题 :Process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes 发明人:MCLAREN LEE; TO DANIEL; TOVELL DAVID; ABELE STEFAN 权利人:IDORSIA PHARMACEUTICALS LTD 摘要:The present invention relates to a process for the manufacturing of 1-aryl-1-trifluoromethylcyclopropanes, which serve as intermediates for the manufacturing of calcium T channel blockers of the general formula (A) n nwhich are described in WO 2015/186056.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-2023279170-A1 优先权日:2022-03-02 标 题:Chiral-substituted poly-n-vinylpyrrolidinones and complexes with bimetallic nanoclusters and uses thereof 发明人:HUA DUY H 权利人:UNIV KANSAS STATE 摘要:Synthesis of chiral polyvinylpyrrolidinone (CSPVP) compounds, complexes of CSPVP with a core species, such as a bimetallic nanocluster catalyst, and selective C—H bond oxidation reactions utilizing such complexes are disclosed. These reaction products can be used as reagents in the synthesis of complex organic molecules, such as bioactive products, and C—H bond oxidation of complex molecules including various drugs and natural products.
专利号:US-2019375702-A1 优先权日:2017-02-06 标 题 :A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes
专利号:US-5959159-A 优先权日:1997-10-24 标题 :Method for preparing optically active 5-hydroxy-3-(4'-hydroxyphenyl)-1,1,3-trimethylindane 发明人:KAZLAUSKAS ROMAS JOSEPH; ZHANG XIAOMING 权利人:MOLECULAR OPTOELECTRONICS CORP 摘要:A process for resolving racemic diesters of (R,S)(±)-5-hydroxy-3-(4'-hydroxyphenyl)-1,1,3-trimethylindane is disclosed. The process utilizes a microbial enzyme derived from Chromobacterium viscosum to catalyze the enantioselective and regioselective hydrolysis of the (S)(-)-enantiomer of the racemic mixture to its corresponding monoester at a faster rate than the (R)(+)-enantiomer. A substantially pure (S)(-)-indane monoester is thereby formed, while the (R)(+)-indane diester remains unreacted. The (S)(-)-monoester and the (R)(+)-diester can then be hydrolyzed using conventional techniques to form optically active (R)(+)- and (S)(-)-5-hydroxy-3-(4'-hydroxyphenyl)-1,1,3-trimethylindane enantiomers for use as monomers in the synthesis of chiral polymers.
摘要:Indian Journal of Physiology and Pharmacology., 24(310), 1980 [] 摘要:Cunha, J. C.; Dedeiras, B.; Negrão, A. C. R.; Marques, M. M. B., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .