CAS: 82317-82-6; Boc-D-Phe(3-Cf3)-Oh
该化合物是一种氨基酸衍生物,其特点是三氟甲基甲基基和二甲基乙氧基保护基组的存在.该化合物的基质为苯丙氨基,因其在蛋白合成中的作用和作为...
- 英文名称Boc-D-Phe(3-Cf3)-Oh
- 中文名称Boc-D-3-三氟甲基苯丙氨酸
- 其它别名B°C-D-Phe(3-CF3)-OH; B°C-D-Phe(3-trifluoromethyl)-OH; B°C-3-(Trifluoromethyl)-D-phenylalanine; tert-Butoxycarbonyl-D-3-trifluoromethylphenylalanine
- CAS编号82317-82-6
- MFCD编号:MFCD00672525
- 分子式:C15H18F3NO4分子量:333.3022
- 产品CID: 1814060
- 产品分类有机原料→生命科学→氨基酸及其衍生物→苯丙氨酸及其衍生物
相似化合物
500770-78-5 142995-31-1 14464-67-6物理性质
MSDS等安全信息
上下游产品
CAS号24424-99-5 二碳酸二叔丁酯 | CAS号82317-79-1 D-3-三氟甲基苯丙氨酸 | CAS号82337-57-3 AC-DL-PHE(3-CF3)-OH | CAS号82317-72-4 methyl 2-acetam... | CAS号82317-76-8 methyl 2-acetam... | CAS号269726-74-1 (R)-3-((叔丁氧羰基)氨...合成工艺路线路线简述
- 24424-99-5 = 82317-82-6
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 16 H,Rt1.2 Solvents: Methanol1.3 Reagents: Triethylamine Solvents: Dichloromethane1.4 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water
标题:Triazolopiperazine-Amides As Dipeptidyl Peptidase Iv Inhibitors: Close Analogs Of Januvia (Sitagliptin Phosphate)
作者:Kim,Dooseop; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2007 卷标:17(12) 页码:3373-3377]
78342-42-4 + 402-23-3 = 82317-82-6
反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran; -78 °C2.1 Reagents: Hydrochloric Acid Solvents: Water; 16 H,Rt2.2 Solvents: Methanol2.3 Reagents: Triethylamine Solvents: Dichloromethane2.4 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water
标题:Triazolopiperazine-Amides As Dipeptidyl Peptidase Iv Inhibitors: Close Analogs Of Januvia (Sitagliptin Phosphate)
作者:Kim,Dooseop; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2007 卷标:17(12) 页码:3373-3377
📜Diethyl α-Acetamido,α-(3-Trifluoromethylbenzyl)Malonate置于盐酸,Sodium Hydroxide,三氟化硼乙醚,Magnesium Oxide体系中,用 1,4-二氧六环 作为反应溶剂,化学反应 3.0H,反应生成 Boc-3-(三氟甲基)-D-苯丙氨酸
参考文献:Synthesis And Biological Activity Of Some Very Hydrophobic Superagonist Analogs Of Luteinizing Hormone-Releasing Hormone
标题:Synthesis And Biological Activity Of Some Very Hydrophobic Superagonist Analogs Of Luteinizing Hormone-Releasing Hormone
摘要:The Effect Of Increased Hydrophobicity At Position 6 Of Luteinizing Hormone-Releasing Hormone (Lh-Rh) Has Been Investigated By The Incorporation Of A Series Of 15 Very Hydrophobic,Unnatural D-Amino Acids At This Position. The Unnatural Amino Acids Studied Can Be Considered Analogues Of Phenylalanine With Carbocyclic Aromatic Side Chains Consisting Of Substituted Phenyl (E.G.,2,4,6-Trimethylphenyl,P-Biphenyl) Or Polycyclic Aromatic (E.G.,Naphthalene,Anthracene) Units. When Enzymatic Resolution (Subtilisin Carlsberg) Of The Most Hydrophobic Amino Acids Failed,The Racemic Amino Acids Were Incorporated,And The Diastereomeric Lh-Rh Analogues Were Resolved By Preparative High-Performance Liquid Chromatography. The Analogues Were Synthesized By The Solid-Phase Technique. All Of The Synthetic Compounds Were Very Potent Lh-Rh Superagonists,But [6-(3-(2-Naphthyl)-D-Alanine)]Lh-Rh,[6-(3-(2-Naphthyl)-D-Alanine),7-(N Alpha-Methylleucine)]Lh-Rh And [6-(3-(2,4,6-Trimethylphenyl)-D-Alanine)]Lh-Rh Appear To Be Among The Most Potent Lh-Rh Agonist Analogues Yet Reported When Tested In A Rat Estrus Cyclicity Suppression Assay Designed To Show The Paradoxical Antifertility Effects Of These Compounds [ed50 Approximately 7 X 10(-8) G; Twice Daily In Saline]. These Analogues Are Twice As Potent As [d-Trp6,Pronhet9]Lh-Rh In This Assay System (I.E.,Approximately 200 Times The Potency Of Lh-Rh).
DOI:10.1021/jm00349A006
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1007/s00894-018-3593-z
摘要:Kapusta K, Sizochenko N, Karabulut S, Okovytyy S, Voronkov E, Leszczynski J. QSPR modeling of optical rotation of amino acids using specific quantum chemical descriptors. Journal of Molecular Modeling. 2018 Feb 17;24(3):59. doi: 10.1007/s00894-018-3593-z.
📝 需求与反馈
尽可能描述清楚需求与问题信息
