CAS: 6711-69-9; Methyl 4-Ethyl-1,2,3A,4,5,7-Hexahydro-3,5-Ethanopyrrolo[2,3-D]Carbazole-6-Carboxylate

上下游产品

(+)-condyl°Carpine carbazole-7-carboxylate(3aRS,4SR,5SR,11bSR)-Methyl 4-ethyl-2,3,3a,4,5,7-hexahydro-3,5-ethano-1H-pyrrolo2,3-dcarbazole-7-carboxylate 16H20N2C16H20N2 indole(1RS,5RS,12SR)-2-Benzyl-12-ethyl-1,2,3,4,5,6-hexahydro-1,5-methanoaz°Cino4,3-bindole

📜(+)-Condylocarpine置于platinum(Iv) Oxide,氢气体系中,用 乙醇 作为反应溶剂,化学反应 1.0H,以91%的收率获得产物土波台文碱
参考文献:(+)-Condylocarpine,(+)-Isocondylocarpine 和 (+)-Tubotaiwine 的全合成
标题:(+)-Condylocarpine,(+)-Isocondylocarpine 和 (+)-Tubotaiwine 的全合成
摘要:报道了第一个对映选择性全合成的髁果类吲哚生物碱.(+)-Condylocarpine,(+)-Isocondylocarpine 和 (+)-Tubotaiwine 从 (1 S,5 R)-Hexahydro-1,5-Methano-1 H以高对映体纯度 (Er > 99:1) 制备-Azocino[4,3-B]Indole-12-One 7B通过五个或六个分离的中间体.
DOI:10.1021/ol102709S

专利信息

专利号:US-11427842-B2
优先权日:2018-03-16
标题 :Method and means for manufacturing terpene indole alkaloids
发明人：O'CONNOR SARAH; CAPUTI LORENZO; PAYNE RICHARD; FRANKE JAKOB; FARROW SCOTT
权利人:INNES JOHN CENTRE
摘要:The complex chemistry underlying the extensive transformations involved in terpene indole alkaloid synthesis makes identification of the biosynthetic genes challenging. The present invention relates to methods for producing a terpene indole alkaloid derivative, comprising the steps of: (1) providing a terpene indole alkaloid; and (2) providing a first enzyme termed “Precondylocarpine Acetate Synthaseâ€? (PAS) or a functional variant or homologue thereof; and/or a second enzyme termed “Dehydroprecondylocarpine Acetate Synthaseâ€? (DPAS) or a functional variant or homologue thereof, and optionally providing further identified enzymes involved in this pathway. The invention also encompasses related kits, enzymes, expression vectors, host cells and plants.