CAS: 630-22-8; 2,2-Dimethylpropanethioamide

相似化合物

13515-65-6 631-58-3 16256-14-7

上下游产品

thiopivalamide S-oxide tert-butyl-5,6-diphenyl-5,6-dihydro-[1,3]thiazin-4-one2-tert-butyl-5,6-diphenyl-5,6-dihydro-[1,3]thiazin-4-one 2,2-Dimethyl-thiopropionimidic acid (Z)-3-oxo-3-phenyl-propenyl ester; compound with perchloric acid 2-(tert-butyl)-4-(4-fluorophenyl)-5-(4-methylthiophenyl)thiazole 2,2-dimethylpropionamide

三甲基乙腈置于sodium Hydrogensulfide,二乙胺盐酸盐体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 48.0H,以50%的收率获得产物2,2,2-三甲基硫代乙酰胺
参考文献:用硫化氢钠和二乙胺盐酸盐从腈中制备伯硫代酰胺
标题:用硫化氢钠和二乙胺盐酸盐从腈中制备伯硫代酰胺
摘要:摘要 通过用硫化氢钠和二乙胺盐酸盐在适当的溶剂中温和加热处理腈,以中等至优异的收率制备伯硫代酰胺.
DOI:10.1080/00397910500377099

专利信息

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:CN-120463658-A
优先权日:2025-04-10
标 题 :Synthesis method of Darafenib key intermediate