CAS: 59768-74-0; Boc-Asp(Ome)-Oh

相似化合物

856417-64-6 124184-67-4 16856-13-6

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号16856-13-6 L-天冬氨酸-β-甲酯盐酸盐 | CAS号2177-62-0 (S)-2-氨基-4-甲氧基-... | CAS号1054666-03-3 (3S,4S)-methyl ... | CAS号30925-18-9 B°C-L-天冬氨酸1-苄酯 | CAS号130622-08-1 L-t-butoxycarbo... | CAS号67-56-1 甲醇 | CAS号7536-58-5 B°C-L-天冬氨酸 4-苄酯 | CAS号90600-20-7 B°C-L-烯丙基甘氨酸 | CAS号34582-32-6 N-叔丁氧羰基-L-天冬氨酸 1-叔丁酯 | CAS号147959-18-0 (S)-N-B°C-2,2-二... | CAS号89985-87-5 (S)-2-((叔丁氧基羰基)...

Boc-L-天冬氨酸二甲酯置于lithium Hydroxide,盐酸体系中,用 乙醇,水 作为反应溶剂,以41.2 G的收率获得产物boc-L-天冬氨酸 4-甲酯
参考文献:通过天冬氨酸等价物的格氏反应合成手性 β-氨基酸衍生物
标题:通过天冬氨酸等价物的格氏反应合成手性 β-氨基酸衍生物
摘要:通过 2,4,5-三氟苯基溴化镁与 L-天冬氨酸的 Weinreb 酰胺衍生物的格利雅反应,开发了一种手性 β-氨基酸衍生物的新合成路线.天冬氨酸等价物由l-天冬氨酸分四步合成,格氏试剂通过br-Mg-交换反应制备.在格氏反应和随后的还原之后获得目标化合物.l-天冬氨酸很好地保留了手性胺的立体结构.
DOI:10.3184/030823410X12843925746143

专利信息

专利号:US-9242925-B2
优先权日:2011-08-29
标题:Versatile and stereospecific synthesis of γ,δ-unsaturated amino acids by Wittig reaction
发明人：JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; ONDEL-EYMIN MARIE-JOELLE
权利人:JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; ONDEL-EYMIN MARIE-JOELLE; CENTRE NAT RECH SCIENT; UNIV BOURGOGNE
摘要:The γ,δ-unsaturated α-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). n n n n n n n n n n n n Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry.

专利号:EP-0790982-B1
优先权日:1994-06-17
标 题 :Methods of synthesis of peptidyl argininals
发明人：WEBB THOMAS R; REINER JOHN E; TAMURA SUSAN Y; RIPKA WILLIAM C; DAGNINO RAYMOND JR; NUTT RUTH F
权利人:CORVAS INT INC
摘要:This invention provides solution-phase and solid-phase methods for the synthesis of peptidyl argininals and to novel reagents useful therein, which have formula (I), wherein R1 is selected from the group consisting of hydrogen, benzyloxycarbonyl, isonicotinyloxycarbonyl, 2-chlorobenzyloxycarbonyl, 4-methoxybenzyloxycarbonyl, t-butoxycarbonyl, t-amyloxycarbonyl, isobornyloxycarbonyl, adamantyloxycarbonyl, 2-(4-biphenyl)-2-propyloxycarbonyl, 9-fluorenylmethoxycarbonyl and methylsulfonylethoxycarbonyl; R2 is selected from the group consisting of alkyl of 1 to about 12 carbon atoms and aralkyl of about 7 to about 15 carbon atoms, either of which is optionally substituted with hydroxy or -CO-Y, wherein Y is hydroxy, alkoxy of 1 to about 12 carbon atoms, aralkoxy of about 7 to about 15 carbon atoms, O-polymeric support or NH-polymeric support; R3 is selected from the group consisting of hydrogen, Fmoc, nitro, benzyloxycarbonyl, t-butoxycarbonyl and adamantyloxycarbonyl; and R4 is selected from the group consisting of hydrogen, alkyl of 1 to about 12 carbon atoms, aryl of about 6 to about 14 carbon atoms and aralkyl of about 7 to about 15 carbon atoms; and salts thereof.

专利号:US-5731413-A
优先权日:1994-06-17
标 题:Method of synthesis of peptidyl aldehydes
发明人：WEBB THOMAS ROY; REINER JOHN EUGENE; TAMURA SUSAN YOSHIKO; RIPKA WILLIAM CHARLES; DAGNINO JR RAYMOND; NUTT RUTH FOELSCHE
权利人:CORVAS INT INC
摘要:This invention provides solution-phase and solid-phase methods for the synthesis of peptidyl argininals and to novel! reagents useful therein.

专利号:EP-0790982-A1
优先权日:1994-06-17
标题:Methods of synthesis of peptidyl argininals

专利号:US-2014364339-A1
优先权日:2011-08-29
标 题 :Versatile and stereospecific synthesis of gamma,delta -unsaturated amino acids by wittig reaction

专利号:US-5514777-A
优先权日:1994-06-17
标 题 :Methods of synthesis of peptidyl argininals